Ablation of atrial fibrillation in patients ≥75 years: long-term clinical outcome and safety

Ilka Metzner; Erik Wissner; Roland R Tilz; Andreas Rillig; Shibu Mathew; Boris Schmidt; Julian Chun; Peter Wohlmuth; Sebastian Deiss; Christine Lemes; Tilman Maurer; Thomas Fink; Christian Heeger; Feifan Ouyang; Karl-Heinz Kuck; Andreas Metzner

doi:10.1093/europace/euv229

Ablation of atrial fibrillation in patients ≥75 years: long-term clinical outcome and safety

Standard

Ablation of atrial fibrillation in patients ≥75 years: long-term clinical outcome and safety. / Metzner, Ilka; Wissner, Erik; Tilz, Roland R; Rillig, Andreas; Mathew, Shibu; Schmidt, Boris; Chun, Julian; Wohlmuth, Peter; Deiss, Sebastian; Lemes, Christine; Maurer, Tilman; Fink, Thomas; Heeger, Christian; Ouyang, Feifan; Kuck, Karl-Heinz; Metzner, Andreas.

in: EUROPACE, Jahrgang 18, Nr. 4, 04.2016, S. 543-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Metzner, I, Wissner, E, Tilz, RR, Rillig, A, Mathew, S, Schmidt, B, Chun, J, Wohlmuth, P, Deiss, S, Lemes, C, Maurer, T, Fink, T, Heeger, C, Ouyang, F, Kuck, K-H & Metzner, A 2016, 'Ablation of atrial fibrillation in patients ≥75 years: long-term clinical outcome and safety', EUROPACE, Jg. 18, Nr. 4, S. 543-9. https://doi.org/10.1093/europace/euv229

APA

Metzner, I., Wissner, E., Tilz, R. R., Rillig, A., Mathew, S., Schmidt, B., Chun, J., Wohlmuth, P., Deiss, S., Lemes, C., Maurer, T., Fink, T., Heeger, C., Ouyang, F., Kuck, K-H., & Metzner, A. (2016). Ablation of atrial fibrillation in patients ≥75 years: long-term clinical outcome and safety. EUROPACE, 18(4), 543-9. https://doi.org/10.1093/europace/euv229

Vancouver

Metzner I, Wissner E, Tilz RR, Rillig A, Mathew S, Schmidt B et al. Ablation of atrial fibrillation in patients ≥75 years: long-term clinical outcome and safety. EUROPACE. 2016 Apr;18(4):543-9. https://doi.org/10.1093/europace/euv229

Bibtex

@article{0f51d5cbf2cb443ca4d9b53b97357e45,

title = "Ablation of atrial fibrillation in patients ≥75 years: long-term clinical outcome and safety",

abstract = "AIMS: The prevalence of atrial fibrillation (AF) increases with age. Catheter ablation is an established treatment option for patients with symptomatic AF. We sought to determine the safety and long-term clinical efficacy of AF ablation in patients ≥75 years.METHODS AND RESULTS: Patients ≥75 years with symptomatic, drug-refractory AF were included in the study. Circumferential pulmonary vein isolation (PVI) was performed in all patients, extended to ablation of complex fractionated atrial electrograms, and/or linear lesions in PVI non-responders. Retrospective follow-up (FU) was based on routine outpatient clinic visits and regular telephone interviews. A total of 94 patients (54 male, age 78 ± 2 years, and left atrium diameter 46 ± 6 mm) with drug-refractory AF [55/94 (59%) paroxysmal AF (PAF), 29/94 (31%) persistent AF, and 10/94 (11%) long-standing persistent AF] underwent ablation. Follow-up was obtained in 93/94 (99%) patients. Following a single procedure, 35/93 (38%) patients were in stable sinus rhythm (SR; 46% PAF, 31% persistent AF, and 10% long-standing persistent AF) after a mean FU of 37 ± 20 months. After a mean of 1.5 ± 0.6 procedures, 55/93 (59%) patients were ultimately in stable SR (76% PAF, 41% persistent AF, and 20% long-standing persistent AF). In a total of 137 procedures, 8 major (5.8%) and 26 minor (19%) complications occurred.CONCLUSIONS: Catheter ablation in patients ≥75 years is associated with a favourable clinical long-term outcome in patients with PAF, while results are less promising in persistent or long-standing persistent patients. The safety profile of AF ablation in patients ≥75 years is comparable with patients of younger age.",

keywords = "Age Factors, Aged, Aged, 80 and over, Anti-Arrhythmia Agents/therapeutic use, Atrial Fibrillation/diagnosis, Catheter Ablation/adverse effects, Drug Resistance, Germany, Humans, Kaplan-Meier Estimate, Male, Pulmonary Veins/physiopathology, Recurrence, Reoperation, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome",

author = "Ilka Metzner and Erik Wissner and Tilz, {Roland R} and Andreas Rillig and Shibu Mathew and Boris Schmidt and Julian Chun and Peter Wohlmuth and Sebastian Deiss and Christine Lemes and Tilman Maurer and Thomas Fink and Christian Heeger and Feifan Ouyang and Karl-Heinz Kuck and Andreas Metzner",

year = "2016",

month = apr,

doi = "10.1093/europace/euv229",

language = "English",

volume = "18",

pages = "543--9",

journal = "EUROPACE",

issn = "1099-5129",

publisher = "Oxford University Press",

number = "4",

}

RIS

TY - JOUR

T1 - Ablation of atrial fibrillation in patients ≥75 years: long-term clinical outcome and safety

AU - Metzner, Ilka

AU - Wissner, Erik

AU - Tilz, Roland R

AU - Rillig, Andreas

AU - Mathew, Shibu

AU - Schmidt, Boris

AU - Chun, Julian

AU - Wohlmuth, Peter

AU - Deiss, Sebastian

AU - Lemes, Christine

AU - Maurer, Tilman

AU - Fink, Thomas

AU - Heeger, Christian

AU - Ouyang, Feifan

AU - Kuck, Karl-Heinz

AU - Metzner, Andreas

PY - 2016/4

Y1 - 2016/4

N2 - AIMS: The prevalence of atrial fibrillation (AF) increases with age. Catheter ablation is an established treatment option for patients with symptomatic AF. We sought to determine the safety and long-term clinical efficacy of AF ablation in patients ≥75 years.METHODS AND RESULTS: Patients ≥75 years with symptomatic, drug-refractory AF were included in the study. Circumferential pulmonary vein isolation (PVI) was performed in all patients, extended to ablation of complex fractionated atrial electrograms, and/or linear lesions in PVI non-responders. Retrospective follow-up (FU) was based on routine outpatient clinic visits and regular telephone interviews. A total of 94 patients (54 male, age 78 ± 2 years, and left atrium diameter 46 ± 6 mm) with drug-refractory AF [55/94 (59%) paroxysmal AF (PAF), 29/94 (31%) persistent AF, and 10/94 (11%) long-standing persistent AF] underwent ablation. Follow-up was obtained in 93/94 (99%) patients. Following a single procedure, 35/93 (38%) patients were in stable sinus rhythm (SR; 46% PAF, 31% persistent AF, and 10% long-standing persistent AF) after a mean FU of 37 ± 20 months. After a mean of 1.5 ± 0.6 procedures, 55/93 (59%) patients were ultimately in stable SR (76% PAF, 41% persistent AF, and 20% long-standing persistent AF). In a total of 137 procedures, 8 major (5.8%) and 26 minor (19%) complications occurred.CONCLUSIONS: Catheter ablation in patients ≥75 years is associated with a favourable clinical long-term outcome in patients with PAF, while results are less promising in persistent or long-standing persistent patients. The safety profile of AF ablation in patients ≥75 years is comparable with patients of younger age.

AB - AIMS: The prevalence of atrial fibrillation (AF) increases with age. Catheter ablation is an established treatment option for patients with symptomatic AF. We sought to determine the safety and long-term clinical efficacy of AF ablation in patients ≥75 years.METHODS AND RESULTS: Patients ≥75 years with symptomatic, drug-refractory AF were included in the study. Circumferential pulmonary vein isolation (PVI) was performed in all patients, extended to ablation of complex fractionated atrial electrograms, and/or linear lesions in PVI non-responders. Retrospective follow-up (FU) was based on routine outpatient clinic visits and regular telephone interviews. A total of 94 patients (54 male, age 78 ± 2 years, and left atrium diameter 46 ± 6 mm) with drug-refractory AF [55/94 (59%) paroxysmal AF (PAF), 29/94 (31%) persistent AF, and 10/94 (11%) long-standing persistent AF] underwent ablation. Follow-up was obtained in 93/94 (99%) patients. Following a single procedure, 35/93 (38%) patients were in stable sinus rhythm (SR; 46% PAF, 31% persistent AF, and 10% long-standing persistent AF) after a mean FU of 37 ± 20 months. After a mean of 1.5 ± 0.6 procedures, 55/93 (59%) patients were ultimately in stable SR (76% PAF, 41% persistent AF, and 20% long-standing persistent AF). In a total of 137 procedures, 8 major (5.8%) and 26 minor (19%) complications occurred.CONCLUSIONS: Catheter ablation in patients ≥75 years is associated with a favourable clinical long-term outcome in patients with PAF, while results are less promising in persistent or long-standing persistent patients. The safety profile of AF ablation in patients ≥75 years is comparable with patients of younger age.

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Anti-Arrhythmia Agents/therapeutic use

KW - Atrial Fibrillation/diagnosis

KW - Catheter Ablation/adverse effects

KW - Drug Resistance

KW - Germany

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Pulmonary Veins/physiopathology

KW - Recurrence

KW - Reoperation

KW - Retrospective Studies

KW - Risk Factors

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1093/europace/euv229

DO - 10.1093/europace/euv229

M3 - SCORING: Journal article

C2 - 26826139

VL - 18

SP - 543

EP - 549

JO - EUROPACE

JF - EUROPACE

SN - 1099-5129

IS - 4

ER -