Aberrant functional connectivity within the salience network is related to cognitive deficits and disorganization in psychosis
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Aberrant functional connectivity within the salience network is related to cognitive deficits and disorganization in psychosis. / Schiwy, Lennart Christopher; Forlim, Caroline Garcia; Fischer, Djo Juliette; Kühn, Simone; Becker, Maxi; Gallinat, Jürgen.
in: SCHIZOPHR RES, Jahrgang 246, 08.2022, S. 103-111.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Aberrant functional connectivity within the salience network is related to cognitive deficits and disorganization in psychosis
AU - Schiwy, Lennart Christopher
AU - Forlim, Caroline Garcia
AU - Fischer, Djo Juliette
AU - Kühn, Simone
AU - Becker, Maxi
AU - Gallinat, Jürgen
N1 - Copyright © 2022 Elsevier B.V. All rights reserved.
PY - 2022/8
Y1 - 2022/8
N2 - In schizophrenia and schizoaffective disorder cognitive deficits are a reliable characteristic predicting a poor functional outcome. It has been theorized that both the default mode network (DMN) and the salience network (SN) play a crucial role in cognitive processes and aberrant functional connectivity within these networks in psychotic patients has been reported. The goal of this study was to reveal potential links between aberrant functional connectivity within these networks and impaired cognitive performance in psychosis. We chose two approaches for cognitive assessment, first the MATRICS Consensus Cognitive Battery (MCCB) combined into a global score and second the disorganization factor derived from a five-factor model of the Positive and Negative Syndrome Scale (PANSS) known to be relevant for cognitive performance. DMN and SN were identified using independent component analysis on resting-state functional magnetic resonance imaging data. We found significantly decreased connectivity within the right supplementary motor area (SMA) and bilateral putamen in patients with psychosis (n = 70; 27F/43M) compared to healthy controls (n = 72; 28F/44M). Within patients, linear regression analysis revealed that aberrant SMA connectivity was associated with impaired global cognition, while dysfunctional bilateral putamen connectivity predicted disorganization. There were no significant changes in connectivity within the DMN. Results support the hypothesis that SN dysfunctional connectivity is important in the pathobiology of cognitive deficits in psychosis. For the first time we were able to show the involvement of dysfunctional SMA connectivity in this context. We interpret the decreased SN connectivity as evidence of reduced functionality in recruiting brain areas necessary for cognitive processing.
AB - In schizophrenia and schizoaffective disorder cognitive deficits are a reliable characteristic predicting a poor functional outcome. It has been theorized that both the default mode network (DMN) and the salience network (SN) play a crucial role in cognitive processes and aberrant functional connectivity within these networks in psychotic patients has been reported. The goal of this study was to reveal potential links between aberrant functional connectivity within these networks and impaired cognitive performance in psychosis. We chose two approaches for cognitive assessment, first the MATRICS Consensus Cognitive Battery (MCCB) combined into a global score and second the disorganization factor derived from a five-factor model of the Positive and Negative Syndrome Scale (PANSS) known to be relevant for cognitive performance. DMN and SN were identified using independent component analysis on resting-state functional magnetic resonance imaging data. We found significantly decreased connectivity within the right supplementary motor area (SMA) and bilateral putamen in patients with psychosis (n = 70; 27F/43M) compared to healthy controls (n = 72; 28F/44M). Within patients, linear regression analysis revealed that aberrant SMA connectivity was associated with impaired global cognition, while dysfunctional bilateral putamen connectivity predicted disorganization. There were no significant changes in connectivity within the DMN. Results support the hypothesis that SN dysfunctional connectivity is important in the pathobiology of cognitive deficits in psychosis. For the first time we were able to show the involvement of dysfunctional SMA connectivity in this context. We interpret the decreased SN connectivity as evidence of reduced functionality in recruiting brain areas necessary for cognitive processing.
KW - Brain/diagnostic imaging
KW - Brain Mapping
KW - Cognition
KW - Humans
KW - Magnetic Resonance Imaging/methods
KW - Nerve Net/diagnostic imaging
KW - Neural Pathways/diagnostic imaging
KW - Psychotic Disorders/complications
KW - Schizophrenia/complications
U2 - 10.1016/j.schres.2022.06.008
DO - 10.1016/j.schres.2022.06.008
M3 - SCORING: Journal article
C2 - 35753120
VL - 246
SP - 103
EP - 111
JO - SCHIZOPHR RES
JF - SCHIZOPHR RES
SN - 0920-9964
ER -
