Aberrant expression of Sec61α in esophageal cancers
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Aberrant expression of Sec61α in esophageal cancers. / Bachmann, Kai; Bockhorn, Maximillian; Mann, Oliver; Gebauer, Florian; Blessmann, Marco; Izbicki, Jakob Robert; Grupp, Katharina.
in: J CANCER RES CLIN, Jahrgang 145, Nr. 8, 08.2019, S. 2039-2044.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Aberrant expression of Sec61α in esophageal cancers
AU - Bachmann, Kai
AU - Bockhorn, Maximillian
AU - Mann, Oliver
AU - Gebauer, Florian
AU - Blessmann, Marco
AU - Izbicki, Jakob Robert
AU - Grupp, Katharina
PY - 2019/8
Y1 - 2019/8
N2 - INTRODUCTION: The heterotrimeric Sec61α translocon complex is topological located in the membrane of the endoplasmic reticulum (ER) and allows protein transport and calcium across the membrane. Recently, aberrant expression of Sec proteins was linked to carcinogenesis and prognosis of patients.MATERIALS AND METHODS: Here, we analysed the role of Sec61α in esophageal cancer, and we analysed Sec61α staining on a tissue microarray containing more than 600 esophageal cancer specimens by immunohistochemistry.RESULTS: Sec61α staining was always strong in benign esophagus, but was only found in 5% of interpretable esophageal adenocarcinomas (EACs) and 14.5% of squamous cell carcinomas (ESCCs). Reduced Sec61α staining was not strongly linked to tumor phenotype in both subgroups of esophageal cancers and was unrelated to clinical outcome of patients (EACs: p = 0.8051 and ESCCs: p = 0.2751).CONCLUSIONS: Thus, Sec61α measurement has not an additional prognostic benefit for the patients.
AB - INTRODUCTION: The heterotrimeric Sec61α translocon complex is topological located in the membrane of the endoplasmic reticulum (ER) and allows protein transport and calcium across the membrane. Recently, aberrant expression of Sec proteins was linked to carcinogenesis and prognosis of patients.MATERIALS AND METHODS: Here, we analysed the role of Sec61α in esophageal cancer, and we analysed Sec61α staining on a tissue microarray containing more than 600 esophageal cancer specimens by immunohistochemistry.RESULTS: Sec61α staining was always strong in benign esophagus, but was only found in 5% of interpretable esophageal adenocarcinomas (EACs) and 14.5% of squamous cell carcinomas (ESCCs). Reduced Sec61α staining was not strongly linked to tumor phenotype in both subgroups of esophageal cancers and was unrelated to clinical outcome of patients (EACs: p = 0.8051 and ESCCs: p = 0.2751).CONCLUSIONS: Thus, Sec61α measurement has not an additional prognostic benefit for the patients.
KW - Adenocarcinoma/diagnosis
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Esophageal Neoplasms/diagnosis
KW - Esophageal Squamous Cell Carcinoma/diagnosis
KW - Female
KW - Humans
KW - Immunohistochemistry
KW - Male
KW - Middle Aged
KW - Predictive Value of Tests
KW - Prognosis
KW - SEC Translocation Channels/metabolism
KW - Tissue Array Analysis
U2 - 10.1007/s00432-019-02955-7
DO - 10.1007/s00432-019-02955-7
M3 - SCORING: Journal article
C2 - 31197453
VL - 145
SP - 2039
EP - 2044
JO - J CANCER RES CLIN
JF - J CANCER RES CLIN
SN - 0171-5216
IS - 8
ER -