A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases
Standard
A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases. / Bernhardt, Alexander M; Tiedt, Steffen; Teupser, Daniel; Dichgans, Martin; Meyer, Bernhard; Gempt, Jens; Kuhn, Peer-Hendrik; Simons, Mikael; Palleis, Carla; Weidinger, Endy; Nübling, Georg; Holdt, Lesca; Hönikl, Lisa; Gasperi, Christiane; Giesbertz, Pieter; Müller, Stephan A; Breimann, Stephan; Lichtenthaler, Stefan F; Kuster, Bernhard; Mann, Matthias; Imhof, Axel; Barth, Teresa; Hauck, Stefanie M; Zetterberg, Henrik; Otto, Markus; Weichert, Wilko; Hemmer, Bernhard; Levin, Johannes.
in: EBIOMEDICINE, Jahrgang 89, 03.2023, S. 104456.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases
AU - Bernhardt, Alexander M
AU - Tiedt, Steffen
AU - Teupser, Daniel
AU - Dichgans, Martin
AU - Meyer, Bernhard
AU - Gempt, Jens
AU - Kuhn, Peer-Hendrik
AU - Simons, Mikael
AU - Palleis, Carla
AU - Weidinger, Endy
AU - Nübling, Georg
AU - Holdt, Lesca
AU - Hönikl, Lisa
AU - Gasperi, Christiane
AU - Giesbertz, Pieter
AU - Müller, Stephan A
AU - Breimann, Stephan
AU - Lichtenthaler, Stefan F
AU - Kuster, Bernhard
AU - Mann, Matthias
AU - Imhof, Axel
AU - Barth, Teresa
AU - Hauck, Stefanie M
AU - Zetterberg, Henrik
AU - Otto, Markus
AU - Weichert, Wilko
AU - Hemmer, Bernhard
AU - Levin, Johannes
N1 - Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
PY - 2023/3
Y1 - 2023/3
N2 - A major evolution from purely clinical diagnoses to biomarker supported clinical diagnosing has been occurring over the past years in neurology. High-throughput methods, such as next-generation sequencing and mass spectrometry-based proteomics along with improved neuroimaging methods, are accelerating this development. This calls for a consensus framework that is broadly applicable and provides a spot-on overview of the clinical validity of novel biomarkers. We propose a harmonized terminology and a uniform concept that stratifies biomarkers according to clinical context of use and evidence levels, adapted from existing frameworks in oncology with a strong focus on (epi)genetic markers and treatment context. We demonstrate that this framework allows for a consistent assessment of clinical validity across disease entities and that sufficient evidence for many clinical applications of protein biomarkers is lacking. Our framework may help to identify promising biomarker candidates and classify their applications by clinical context, aiming for routine clinical use of (protein) biomarkers in neurology.
AB - A major evolution from purely clinical diagnoses to biomarker supported clinical diagnosing has been occurring over the past years in neurology. High-throughput methods, such as next-generation sequencing and mass spectrometry-based proteomics along with improved neuroimaging methods, are accelerating this development. This calls for a consensus framework that is broadly applicable and provides a spot-on overview of the clinical validity of novel biomarkers. We propose a harmonized terminology and a uniform concept that stratifies biomarkers according to clinical context of use and evidence levels, adapted from existing frameworks in oncology with a strong focus on (epi)genetic markers and treatment context. We demonstrate that this framework allows for a consistent assessment of clinical validity across disease entities and that sufficient evidence for many clinical applications of protein biomarkers is lacking. Our framework may help to identify promising biomarker candidates and classify their applications by clinical context, aiming for routine clinical use of (protein) biomarkers in neurology.
KW - Humans
KW - Biomarkers
KW - Nervous System Diseases
KW - Proteomics/methods
KW - Mass Spectrometry
KW - Neuroimaging
U2 - 10.1016/j.ebiom.2023.104456
DO - 10.1016/j.ebiom.2023.104456
M3 - SCORING: Review article
C2 - 36745974
VL - 89
SP - 104456
JO - EBIOMEDICINE
JF - EBIOMEDICINE
SN - 2352-3964
ER -