A therapeutic exploratory study to determine the efficacy and safety of calcineurin-inhibitor-free de-novo immunosuppression after liver transplantation: CILT.
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A therapeutic exploratory study to determine the efficacy and safety of calcineurin-inhibitor-free de-novo immunosuppression after liver transplantation: CILT. / Goralczyk, Armin D; Schnitzbauer, Andreas; Tsui, Tung Yu; Ramadori, Giuliano; Lorf, Thomas; Obed, Aiman.
in: BMC SURG, Jahrgang 10, 2010, S. 15.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A therapeutic exploratory study to determine the efficacy and safety of calcineurin-inhibitor-free de-novo immunosuppression after liver transplantation: CILT.
AU - Goralczyk, Armin D
AU - Schnitzbauer, Andreas
AU - Tsui, Tung Yu
AU - Ramadori, Giuliano
AU - Lorf, Thomas
AU - Obed, Aiman
PY - 2010
Y1 - 2010
N2 - Immunosuppression with calcineurin inhibitors (CNI) increases the risk of renal dysfunction after orthotopic liver transplantation (OLT). Controlled trials have shown improvement of renal function in patients that received delayed and/or reduced-dose CNI after OLT. Delaying immunosuppression with CNI in combination with induction therapy does not increase the risk of acute rejection but reduces the incidence of acute renal dysfunction. Based on this clinical data this study protocol was designed to assess the efficacy and safety of calcineurin-inhibitor-free de-novo immunosuppression after liver transplantation.
AB - Immunosuppression with calcineurin inhibitors (CNI) increases the risk of renal dysfunction after orthotopic liver transplantation (OLT). Controlled trials have shown improvement of renal function in patients that received delayed and/or reduced-dose CNI after OLT. Delaying immunosuppression with CNI in combination with induction therapy does not increase the risk of acute rejection but reduces the incidence of acute renal dysfunction. Based on this clinical data this study protocol was designed to assess the efficacy and safety of calcineurin-inhibitor-free de-novo immunosuppression after liver transplantation.
U2 - 10.1186/1471-2482-10-15
DO - 10.1186/1471-2482-10-15
M3 - SCORING: Zeitschriftenaufsatz
VL - 10
SP - 15
JO - BMC SURG
JF - BMC SURG
SN - 1471-2482
ER -