A Synthetic Non-degradable Polyethylene Glycol Hydrogel Retards Adverse Post-infarct Left Ventricular Remodeling
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A Synthetic Non-degradable Polyethylene Glycol Hydrogel Retards Adverse Post-infarct Left Ventricular Remodeling. / Dobner, Stephan; Bezuidenhout, Deon; Govender, Padmini; Zilla, Peter; Davies, Neil.
in: J CARD FAIL, Jahrgang 15, Nr. 7, 09.2009, S. 629-636.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A Synthetic Non-degradable Polyethylene Glycol Hydrogel Retards Adverse Post-infarct Left Ventricular Remodeling
AU - Dobner, Stephan
AU - Bezuidenhout, Deon
AU - Govender, Padmini
AU - Zilla, Peter
AU - Davies, Neil
N1 - Funding Information: Supported by collaborative funding from Medtronic Inc., and by a grant from the Technology and Human Resources for Industry Program (THRIP) TP2007080700007, National Research Foundation, South Africa.
PY - 2009/9
Y1 - 2009/9
N2 - Background: Left ventricular remodeling after myocardial infarction is a key component of heart failure and it has long been postulated that it may result from increased wall stress. It has recently been suggested that an injectable, non-degradable polymer may limit pathological remodeling in a manner analogous to that of cardiac support devices. We have tested a non-degradable polyethylene glycol (PEG) gel in a rat infarction model. Methods and Results: After permanent ligation of the left anterior descending artery in male Wistar rats, PEG gel reagents were injected into the infarcted region and polymerized in situ. At 4 weeks, fractional shortening and infarct volume were unchanged relative to a saline injected control, but the infarct-induced left ventricular end-diastolic diameter (LVEDD) increase was substantially reduced (43%, P < .05) and wall thinning was completely prevented. At 13 weeks, the LVEDD were similar for both saline- and PEG-injected hearts. The non-degradable PEG gels did elicit a macrophage-based inflammatory reaction. Conclusions: The injection of non-degradable synthetic gel was effective in ameliorating pathological remodeling in the immediate postinfarction healing phase, but was unable to prevent the dilation that occurred at later stages in the healed heart.
AB - Background: Left ventricular remodeling after myocardial infarction is a key component of heart failure and it has long been postulated that it may result from increased wall stress. It has recently been suggested that an injectable, non-degradable polymer may limit pathological remodeling in a manner analogous to that of cardiac support devices. We have tested a non-degradable polyethylene glycol (PEG) gel in a rat infarction model. Methods and Results: After permanent ligation of the left anterior descending artery in male Wistar rats, PEG gel reagents were injected into the infarcted region and polymerized in situ. At 4 weeks, fractional shortening and infarct volume were unchanged relative to a saline injected control, but the infarct-induced left ventricular end-diastolic diameter (LVEDD) increase was substantially reduced (43%, P < .05) and wall thinning was completely prevented. At 13 weeks, the LVEDD were similar for both saline- and PEG-injected hearts. The non-degradable PEG gels did elicit a macrophage-based inflammatory reaction. Conclusions: The injection of non-degradable synthetic gel was effective in ameliorating pathological remodeling in the immediate postinfarction healing phase, but was unable to prevent the dilation that occurred at later stages in the healed heart.
KW - Myocardial infarction biomaterial
UR - http://www.scopus.com/inward/record.url?scp=68849129381&partnerID=8YFLogxK
U2 - 10.1016/j.cardfail.2009.03.003
DO - 10.1016/j.cardfail.2009.03.003
M3 - SCORING: Journal article
C2 - 19700140
AN - SCOPUS:68849129381
VL - 15
SP - 629
EP - 636
JO - J CARD FAIL
JF - J CARD FAIL
SN - 1071-9164
IS - 7
ER -
