A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44
Standard
A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44. / Niehrs, Annika; Garcia-Beltran, Wilfredo F; Norman, Paul J; Watson, Gabrielle M; Hölzemer, Angelique; Chapel, Anaïs; Richert, Laura; Pommerening-Röser, Andreas; Körner, Christian; Ozawa, Mikki; Martrus, Glòria; Rossjohn, Jamie; Lee, Jar-How; Berry, Richard; Carrington, Mary; Altfeld, Marcus.
in: NAT IMMUNOL, Jahrgang 20, Nr. 9, 09.2019, S. 1129-1137.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44
AU - Niehrs, Annika
AU - Garcia-Beltran, Wilfredo F
AU - Norman, Paul J
AU - Watson, Gabrielle M
AU - Hölzemer, Angelique
AU - Chapel, Anaïs
AU - Richert, Laura
AU - Pommerening-Röser, Andreas
AU - Körner, Christian
AU - Ozawa, Mikki
AU - Martrus, Glòria
AU - Rossjohn, Jamie
AU - Lee, Jar-How
AU - Berry, Richard
AU - Carrington, Mary
AU - Altfeld, Marcus
PY - 2019/9
Y1 - 2019/9
N2 - Natural killer (NK) cells can recognize virus-infected and stressed cells1 using activating and inhibitory receptors, many of which interact with HLA class I. Although early studies also suggested a functional impact of HLA class II on NK cell activity2,3, the NK cell receptors that specifically recognize HLA class II molecules have never been identified. We investigated whether two major families of NK cell receptors, killer-cell immunoglobulin-like receptors (KIRs) and natural cytotoxicity receptors (NCRs), contained receptors that bound to HLA class II, and identified a direct interaction between the NK cell receptor NKp44 and a subset of HLA-DP molecules, including HLA-DP401, one of the most frequent class II allotypes in white populations4. Using NKp44ζ+ reporter cells and primary human NKp44+ NK cells, we demonstrated that interactions between NKp44 and HLA-DP401 trigger functional NK cell responses. This interaction between a subset of HLA-DP molecules and NKp44 implicates HLA class II as a component of the innate immune response, much like HLA class I. It also provides a potential mechanism for the described associations between HLA-DP subtypes and several disease outcomes, including hepatitis B virus infection5-7, graft-versus-host disease8 and inflammatory bowel disease9,10.
AB - Natural killer (NK) cells can recognize virus-infected and stressed cells1 using activating and inhibitory receptors, many of which interact with HLA class I. Although early studies also suggested a functional impact of HLA class II on NK cell activity2,3, the NK cell receptors that specifically recognize HLA class II molecules have never been identified. We investigated whether two major families of NK cell receptors, killer-cell immunoglobulin-like receptors (KIRs) and natural cytotoxicity receptors (NCRs), contained receptors that bound to HLA class II, and identified a direct interaction between the NK cell receptor NKp44 and a subset of HLA-DP molecules, including HLA-DP401, one of the most frequent class II allotypes in white populations4. Using NKp44ζ+ reporter cells and primary human NKp44+ NK cells, we demonstrated that interactions between NKp44 and HLA-DP401 trigger functional NK cell responses. This interaction between a subset of HLA-DP molecules and NKp44 implicates HLA class II as a component of the innate immune response, much like HLA class I. It also provides a potential mechanism for the described associations between HLA-DP subtypes and several disease outcomes, including hepatitis B virus infection5-7, graft-versus-host disease8 and inflammatory bowel disease9,10.
KW - Cell Line
KW - Graft vs Host Disease/immunology
KW - HLA-DP Antigens/immunology
KW - Hepatitis B/immunology
KW - Humans
KW - Immunity, Innate/immunology
KW - Inflammatory Bowel Diseases/immunology
KW - Jurkat Cells
KW - Killer Cells, Natural/immunology
KW - Natural Cytotoxicity Triggering Receptor 2/immunology
U2 - 10.1038/s41590-019-0448-4
DO - 10.1038/s41590-019-0448-4
M3 - SCORING: Journal article
C2 - 31358998
VL - 20
SP - 1129
EP - 1137
JO - NAT IMMUNOL
JF - NAT IMMUNOL
SN - 1529-2908
IS - 9
ER -