A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity.

Thomas Deller; Carlos Bas Orth; Del Turco Domenico; Andreas Vlachos; Guido J Burbach; Alexander Drakew; Sophie Chabanis; Martin Korte; Herbert Schwegler; Carola A Haas; Michael Frotscher

A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity.

Standard

A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. / Deller, Thomas; Orth, Carlos Bas; Domenico, Del Turco; Vlachos, Andreas; Burbach, Guido J; Drakew, Alexander; Chabanis, Sophie; Korte, Martin; Schwegler, Herbert; Haas, Carola A; Frotscher, Michael.

in: ANN ANAT, Jahrgang 189, Nr. 1, 1, 2007, S. 5-16.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Deller, T, Orth, CB, Domenico, DT, Vlachos, A, Burbach, GJ, Drakew, A, Chabanis, S, Korte, M, Schwegler, H, Haas, CA & Frotscher, M 2007, 'A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity.', ANN ANAT, Jg. 189, Nr. 1, 1, S. 5-16. <http://www.ncbi.nlm.nih.gov/pubmed/17319604?dopt=Citation>

APA

Deller, T., Orth, C. B., Domenico, D. T., Vlachos, A., Burbach, G. J., Drakew, A., Chabanis, S., Korte, M., Schwegler, H., Haas, C. A., & Frotscher, M. (2007). A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. ANN ANAT, 189(1), 5-16. [1]. http://www.ncbi.nlm.nih.gov/pubmed/17319604?dopt=Citation

Vancouver

Deller T, Orth CB, Domenico DT, Vlachos A, Burbach GJ, Drakew A et al. A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. ANN ANAT. 2007;189(1):5-16. 1.

Bibtex

@article{77eafb7d8b7c446387d0bebd67891815,

title = "A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity.",

abstract = "Spines are considered sites of synaptic plasticity in the brain and are capable of remodeling their shape and size. A molecule thathas been implicated in spine plasticity is the actin-associated protein synaptopodin. This article will review a series of studies aimed at elucidating the role of synaptopodin in the rodent brain. First, the developmental expression of synaptopodin mRNA and protein were studied; secondly, the subcellular localization of synaptopodin in hippocampal principal neurons was analyzed using confocal microscopy as well as electron microscopy and immunogold labelling; and, finally, the functional role of synaptopodin was investigated using a synaptopodin-deficient mouse. The results of these studies are: (1) synaptopodin expression byhippocampal principal neurons develops during the first postnatal weeks and increases in parallel with the maturation of spines in the hippocampus. (2) Synaptopodin is sorted to the spine compartment, where it is tightly associated with the spine apparatus, an enigmatic organelle believed to be involved in calcium storage or local protein synthesis. (3) Synaptopodin-deficient mice generated by gene targeting are viable but lack the spine apparatus organelle. These mice show deficitsin synaptic plasticity as well as impaired learning and memory. Taken together, these data implicate synaptopodin and the spine apparatus in the regulation of synaptic plasticity in the hippocampus. Future studies will be aimed at finding the molecular link between synaptopodin, the spine apparatus organelle, and synaptic plasticity.",

keywords = "Animals, Rats, Synapses physiology, Neuronal Plasticity physiology, Actins physiology, Calcium physiology, Hippocampus physiology, Microfilament Proteins physiology, Pyramidal Cells physiology, Spinal Cord physiology, Animals, Rats, Synapses physiology, Neuronal Plasticity physiology, Actins physiology, Calcium physiology, Hippocampus physiology, Microfilament Proteins physiology, Pyramidal Cells physiology, Spinal Cord physiology",

author = "Thomas Deller and Orth, {Carlos Bas} and Domenico, {Del Turco} and Andreas Vlachos and Burbach, {Guido J} and Alexander Drakew and Sophie Chabanis and Martin Korte and Herbert Schwegler and Haas, {Carola A} and Michael Frotscher",

year = "2007",

language = "Deutsch",

volume = "189",

pages = "5--16",

journal = "ANN ANAT",

issn = "0940-9602",

publisher = "Urban und Fischer Verlag Jena",

number = "1",

}

RIS

TY - JOUR

T1 - A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity.

AU - Deller, Thomas

AU - Orth, Carlos Bas

AU - Domenico, Del Turco

AU - Vlachos, Andreas

AU - Burbach, Guido J

AU - Drakew, Alexander

AU - Chabanis, Sophie

AU - Korte, Martin

AU - Schwegler, Herbert

AU - Haas, Carola A

AU - Frotscher, Michael

PY - 2007

Y1 - 2007

N2 - Spines are considered sites of synaptic plasticity in the brain and are capable of remodeling their shape and size. A molecule thathas been implicated in spine plasticity is the actin-associated protein synaptopodin. This article will review a series of studies aimed at elucidating the role of synaptopodin in the rodent brain. First, the developmental expression of synaptopodin mRNA and protein were studied; secondly, the subcellular localization of synaptopodin in hippocampal principal neurons was analyzed using confocal microscopy as well as electron microscopy and immunogold labelling; and, finally, the functional role of synaptopodin was investigated using a synaptopodin-deficient mouse. The results of these studies are: (1) synaptopodin expression byhippocampal principal neurons develops during the first postnatal weeks and increases in parallel with the maturation of spines in the hippocampus. (2) Synaptopodin is sorted to the spine compartment, where it is tightly associated with the spine apparatus, an enigmatic organelle believed to be involved in calcium storage or local protein synthesis. (3) Synaptopodin-deficient mice generated by gene targeting are viable but lack the spine apparatus organelle. These mice show deficitsin synaptic plasticity as well as impaired learning and memory. Taken together, these data implicate synaptopodin and the spine apparatus in the regulation of synaptic plasticity in the hippocampus. Future studies will be aimed at finding the molecular link between synaptopodin, the spine apparatus organelle, and synaptic plasticity.

AB - Spines are considered sites of synaptic plasticity in the brain and are capable of remodeling their shape and size. A molecule thathas been implicated in spine plasticity is the actin-associated protein synaptopodin. This article will review a series of studies aimed at elucidating the role of synaptopodin in the rodent brain. First, the developmental expression of synaptopodin mRNA and protein were studied; secondly, the subcellular localization of synaptopodin in hippocampal principal neurons was analyzed using confocal microscopy as well as electron microscopy and immunogold labelling; and, finally, the functional role of synaptopodin was investigated using a synaptopodin-deficient mouse. The results of these studies are: (1) synaptopodin expression byhippocampal principal neurons develops during the first postnatal weeks and increases in parallel with the maturation of spines in the hippocampus. (2) Synaptopodin is sorted to the spine compartment, where it is tightly associated with the spine apparatus, an enigmatic organelle believed to be involved in calcium storage or local protein synthesis. (3) Synaptopodin-deficient mice generated by gene targeting are viable but lack the spine apparatus organelle. These mice show deficitsin synaptic plasticity as well as impaired learning and memory. Taken together, these data implicate synaptopodin and the spine apparatus in the regulation of synaptic plasticity in the hippocampus. Future studies will be aimed at finding the molecular link between synaptopodin, the spine apparatus organelle, and synaptic plasticity.

KW - Animals

KW - Rats

KW - Synapses physiology

KW - Neuronal Plasticity physiology

KW - Actins physiology

KW - Calcium physiology

KW - Hippocampus physiology

KW - Microfilament Proteins physiology

KW - Pyramidal Cells physiology

KW - Spinal Cord physiology

KW - Animals

KW - Rats

KW - Synapses physiology

KW - Neuronal Plasticity physiology

KW - Actins physiology

KW - Calcium physiology

KW - Hippocampus physiology

KW - Microfilament Proteins physiology

KW - Pyramidal Cells physiology

KW - Spinal Cord physiology

M3 - SCORING: Zeitschriftenaufsatz

VL - 189

SP - 5

EP - 16

JO - ANN ANAT

JF - ANN ANAT

SN - 0940-9602

IS - 1

M1 - 1

ER -