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A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis

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A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis. / Aftahy, A Kaywan; Butenschoen, Vicki M; Hoenikl, Lisa; Liesche-Starnecker, Friederike; Wiestler, Benedikt; Schmidt-Graf, Friederike; Meyer, Bernhard; Gempt, Jens.

in: BMC NEUROL, Jahrgang 23, Nr. 1, 28.02.2023, S. 87.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Aftahy, AK, Butenschoen, VM, Hoenikl, L, Liesche-Starnecker, F, Wiestler, B, Schmidt-Graf, F, Meyer, B & Gempt, J 2023, 'A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis', BMC NEUROL, Jg. 23, Nr. 1, S. 87. https://doi.org/10.1186/s12883-023-03135-4

APA

Aftahy, A. K., Butenschoen, V. M., Hoenikl, L., Liesche-Starnecker, F., Wiestler, B., Schmidt-Graf, F., Meyer, B., & Gempt, J. (2023). A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis. BMC NEUROL, 23(1), 87. https://doi.org/10.1186/s12883-023-03135-4

Vancouver

Aftahy AK, Butenschoen VM, Hoenikl L, Liesche-Starnecker F, Wiestler B, Schmidt-Graf F et al. A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis. BMC NEUROL. 2023 Feb 28;23(1):87. https://doi.org/10.1186/s12883-023-03135-4

Bibtex

@article{b686c7cd475e4f9196e9d4bff000f39a,
title = "A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis",
abstract = "BACKGROUND: H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses.CASE PRESENTATION: We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented with back pain, hemi-hypoesthesia, and hemi-hyperhidrosis. The patient underwent combined radio-chemotherapy and demonstrated temporary improvement before deteriorating.CONCLUSIONS: H3K27-altered diffuse midline glioma presents an infrequent but crucial differential diagnosis and should be considered in cases with rapid neurological deterioration and multiple intracranial and intramedullary tumor lesions in children and young adults. Combined radio-chemotherapy delayed the neurological deterioration, but unfortunately, progression occurred three months after the diagnosis.",
keywords = "Child, Male, Young Adult, Humans, Adult, Spinal Neoplasms/complications, Diagnosis, Differential, Bone and Bones, Antineoplastic Combined Chemotherapy Protocols, Glioma",
author = "Aftahy, {A Kaywan} and Butenschoen, {Vicki M} and Lisa Hoenikl and Friederike Liesche-Starnecker and Benedikt Wiestler and Friederike Schmidt-Graf and Bernhard Meyer and Jens Gempt",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = feb,
day = "28",
doi = "10.1186/s12883-023-03135-4",
language = "English",
volume = "23",
pages = "87",
journal = "BMC NEUROL",
issn = "1471-2377",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis

AU - Aftahy, A Kaywan

AU - Butenschoen, Vicki M

AU - Hoenikl, Lisa

AU - Liesche-Starnecker, Friederike

AU - Wiestler, Benedikt

AU - Schmidt-Graf, Friederike

AU - Meyer, Bernhard

AU - Gempt, Jens

N1 - © 2023. The Author(s).

PY - 2023/2/28

Y1 - 2023/2/28

N2 - BACKGROUND: H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses.CASE PRESENTATION: We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented with back pain, hemi-hypoesthesia, and hemi-hyperhidrosis. The patient underwent combined radio-chemotherapy and demonstrated temporary improvement before deteriorating.CONCLUSIONS: H3K27-altered diffuse midline glioma presents an infrequent but crucial differential diagnosis and should be considered in cases with rapid neurological deterioration and multiple intracranial and intramedullary tumor lesions in children and young adults. Combined radio-chemotherapy delayed the neurological deterioration, but unfortunately, progression occurred three months after the diagnosis.

AB - BACKGROUND: H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses.CASE PRESENTATION: We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented with back pain, hemi-hypoesthesia, and hemi-hyperhidrosis. The patient underwent combined radio-chemotherapy and demonstrated temporary improvement before deteriorating.CONCLUSIONS: H3K27-altered diffuse midline glioma presents an infrequent but crucial differential diagnosis and should be considered in cases with rapid neurological deterioration and multiple intracranial and intramedullary tumor lesions in children and young adults. Combined radio-chemotherapy delayed the neurological deterioration, but unfortunately, progression occurred three months after the diagnosis.

KW - Child

KW - Male

KW - Young Adult

KW - Humans

KW - Adult

KW - Spinal Neoplasms/complications

KW - Diagnosis, Differential

KW - Bone and Bones

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Glioma

U2 - 10.1186/s12883-023-03135-4

DO - 10.1186/s12883-023-03135-4

M3 - SCORING: Journal article

C2 - 36855102

VL - 23

SP - 87

JO - BMC NEUROL

JF - BMC NEUROL

SN - 1471-2377

IS - 1

ER -