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A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis

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A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis. / Coe, Shelly; Cossington, Jo; Collett, Johnny; Soundy, Andrew; Izadi, Hooshang; Ovington, Martin; Durkin, Luke; Kirsten, Maja; Clegg, Miriam; Cavey, Ana; Wade, Derick T; Palace, Jacqueline; DeLuca, Gabriele C; Chapman, Kim; Harrison, Jane-Marie; Buckingham, Elizabeth; Dawes, Helen.

in: J NEUROL NEUROSUR PS, Jahrgang 90, Nr. 5, 05.2019, S. 507-513.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Coe, S, Cossington, J, Collett, J, Soundy, A, Izadi, H, Ovington, M, Durkin, L, Kirsten, M, Clegg, M, Cavey, A, Wade, DT, Palace, J, DeLuca, GC, Chapman, K, Harrison, J-M, Buckingham, E & Dawes, H 2019, 'A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis', J NEUROL NEUROSUR PS, Jg. 90, Nr. 5, S. 507-513. https://doi.org/10.1136/jnnp-2018- 319496

APA

Coe, S., Cossington, J., Collett, J., Soundy, A., Izadi, H., Ovington, M., Durkin, L., Kirsten, M., Clegg, M., Cavey, A., Wade, D. T., Palace, J., DeLuca, G. C., Chapman, K., Harrison, J-M., Buckingham, E., & Dawes, H. (2019). A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis. J NEUROL NEUROSUR PS, 90(5), 507-513. https://doi.org/10.1136/jnnp-2018- 319496

Vancouver

Coe S, Cossington J, Collett J, Soundy A, Izadi H, Ovington M et al. A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis. J NEUROL NEUROSUR PS. 2019 Mai;90(5):507-513. https://doi.org/10.1136/jnnp-2018- 319496

Bibtex

@article{c1e104a37cea4f2c8908791467725fa4,
title = "A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis",
abstract = "The impact of flavonoids on fatigue has not been investigated in relapsing and remitting multiple sclerosis (RRMS).OBJECTIVE: To determine the feasibility and estimate the potential effect of flavonoid-rich cocoa on fatigue and fatigability in RRMS.METHODS: A randomised double-blind placebo-controlled feasibility study in people recently diagnosed with RRMS and fatigue, throughout the Thames Valley, UK (ISRCTN: 69897291). During a 6-week intervention participants consumed a high or low flavonoid cocoa beverage daily. Fatigue and fatigability were measured at three visits (weeks 0, 3 and 6). Feasibility and fidelity were assessed through recruitment and retention, adherence and a process evaluation.RESULTS: 40 people with multiple sclerosis (10 men, 30 women, age 44±10 years) were randomised and allocated to high (n=19) or low (n=21) flavonoid groups and included in analysis. Missing data were <20% and adherence to intervention of allocated individuals was >75%. There was a small effect on fatigue (Neuro-QoL: effect size (ES) 0.04, 95% CI -0.40 to 0.48) and a moderate effect on fatigability (6 min walk test: ES 0.45, 95% CI -0.18 to 1.07). There were seven adverse events (four control, three intervention), only one of which was possibly related and it was resolved.CONCLUSION: A flavonoid beverage demonstrates the potential to improve fatigue and fatigability in RRMS.",
keywords = "Journal Article",
author = "Shelly Coe and Jo Cossington and Johnny Collett and Andrew Soundy and Hooshang Izadi and Martin Ovington and Luke Durkin and Maja Kirsten and Miriam Clegg and Ana Cavey and Wade, {Derick T} and Jacqueline Palace and DeLuca, {Gabriele C} and Kim Chapman and Jane-Marie Harrison and Elizabeth Buckingham and Helen Dawes",
note = "{\textcopyright} Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
month = may,
doi = "10.1136/jnnp-2018- 319496",
language = "English",
volume = "90",
pages = "507--513",
journal = "J NEUROL NEUROSUR PS",
issn = "0022-3050",
publisher = "BMJ PUBLISHING GROUP",
number = "5",

}

RIS

TY - JOUR

T1 - A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis

AU - Coe, Shelly

AU - Cossington, Jo

AU - Collett, Johnny

AU - Soundy, Andrew

AU - Izadi, Hooshang

AU - Ovington, Martin

AU - Durkin, Luke

AU - Kirsten, Maja

AU - Clegg, Miriam

AU - Cavey, Ana

AU - Wade, Derick T

AU - Palace, Jacqueline

AU - DeLuca, Gabriele C

AU - Chapman, Kim

AU - Harrison, Jane-Marie

AU - Buckingham, Elizabeth

AU - Dawes, Helen

N1 - © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019/5

Y1 - 2019/5

N2 - The impact of flavonoids on fatigue has not been investigated in relapsing and remitting multiple sclerosis (RRMS).OBJECTIVE: To determine the feasibility and estimate the potential effect of flavonoid-rich cocoa on fatigue and fatigability in RRMS.METHODS: A randomised double-blind placebo-controlled feasibility study in people recently diagnosed with RRMS and fatigue, throughout the Thames Valley, UK (ISRCTN: 69897291). During a 6-week intervention participants consumed a high or low flavonoid cocoa beverage daily. Fatigue and fatigability were measured at three visits (weeks 0, 3 and 6). Feasibility and fidelity were assessed through recruitment and retention, adherence and a process evaluation.RESULTS: 40 people with multiple sclerosis (10 men, 30 women, age 44±10 years) were randomised and allocated to high (n=19) or low (n=21) flavonoid groups and included in analysis. Missing data were <20% and adherence to intervention of allocated individuals was >75%. There was a small effect on fatigue (Neuro-QoL: effect size (ES) 0.04, 95% CI -0.40 to 0.48) and a moderate effect on fatigability (6 min walk test: ES 0.45, 95% CI -0.18 to 1.07). There were seven adverse events (four control, three intervention), only one of which was possibly related and it was resolved.CONCLUSION: A flavonoid beverage demonstrates the potential to improve fatigue and fatigability in RRMS.

AB - The impact of flavonoids on fatigue has not been investigated in relapsing and remitting multiple sclerosis (RRMS).OBJECTIVE: To determine the feasibility and estimate the potential effect of flavonoid-rich cocoa on fatigue and fatigability in RRMS.METHODS: A randomised double-blind placebo-controlled feasibility study in people recently diagnosed with RRMS and fatigue, throughout the Thames Valley, UK (ISRCTN: 69897291). During a 6-week intervention participants consumed a high or low flavonoid cocoa beverage daily. Fatigue and fatigability were measured at three visits (weeks 0, 3 and 6). Feasibility and fidelity were assessed through recruitment and retention, adherence and a process evaluation.RESULTS: 40 people with multiple sclerosis (10 men, 30 women, age 44±10 years) were randomised and allocated to high (n=19) or low (n=21) flavonoid groups and included in analysis. Missing data were <20% and adherence to intervention of allocated individuals was >75%. There was a small effect on fatigue (Neuro-QoL: effect size (ES) 0.04, 95% CI -0.40 to 0.48) and a moderate effect on fatigability (6 min walk test: ES 0.45, 95% CI -0.18 to 1.07). There were seven adverse events (four control, three intervention), only one of which was possibly related and it was resolved.CONCLUSION: A flavonoid beverage demonstrates the potential to improve fatigue and fatigability in RRMS.

KW - Journal Article

U2 - 10.1136/jnnp-2018- 319496

DO - 10.1136/jnnp-2018- 319496

M3 - SCORING: Journal article

C2 - 30833449

VL - 90

SP - 507

EP - 513

JO - J NEUROL NEUROSUR PS

JF - J NEUROL NEUROSUR PS

SN - 0022-3050

IS - 5

ER -