A novel flexible cryoprobe for EUS-guided pancreatic biopsies
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A novel flexible cryoprobe for EUS-guided pancreatic biopsies. / von Renteln, Daniel; Quaas, Alexander; Rösch, Thomas; Denzer, Ulrike W; Szyrach, Mara N; Enderle, Markus D; Lüth, Stefan; Haas, Sebastian; Trepte, Constantin; Reuter, Daniel; Schachschal, Guido.
in: GASTROINTEST ENDOSC, Jahrgang 77, Nr. 5, 01.05.2013, S. 784-92.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A novel flexible cryoprobe for EUS-guided pancreatic biopsies
AU - von Renteln, Daniel
AU - Quaas, Alexander
AU - Rösch, Thomas
AU - Denzer, Ulrike W
AU - Szyrach, Mara N
AU - Enderle, Markus D
AU - Lüth, Stefan
AU - Haas, Sebastian
AU - Trepte, Constantin
AU - Reuter, Daniel
AU - Schachschal, Guido
N1 - Copyright © 2013 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
PY - 2013/5/1
Y1 - 2013/5/1
N2 - BACKGROUND: EUS-guided FNA (EUS-FNA) is an established technique for the cytologic diagnosis of pancreatic disease. Attempts to obtain adequate histologic specimens have yielded variable and mostly insufficient results.OBJECTIVE: To evaluate the safety, feasibility, and quality of histologic biopsy specimens obtained by using a new cryobiopsy probe and to compare them with standard EUS-FNA and (laparoscopic) trucut biopsy specimens of pancreatic tissue.DESIGN: Animal non-survival study.INTERVENTION: Eighty-four pancreatic biopsy specimens (12 per group) were obtained in 4 anesthetized pigs by using one of the following the 18-gauge flexible cryoprobe; a conventional, 19-gauge, EUS-FNA needle; or a rigid, trucut biopsy device (18 gauge). The latter, used in laparoscopic surgery, was considered as the criterion standard for obtaining histology specimens.MAIN OUTCOME MEASUREMENTS: Specimens were evaluated for artifacts and specimen quality by a blinded pathologist who used a 7-point Likert scale to assess histologic adequacy. Biopsy size and bleeding time after biopsy also were recorded.RESULTS: The new cryoprobe was equivalent to the rigid, trucut needle and superior (P < .001) to the conventional 19-gauge FNA needles with respect to artifacts, quality of the specimen, biopsy specimen size, and bleeding.LIMITATIONS: Animal model.CONCLUSION: EUS-guided cryobiopsy was associated with better specimen quality for histologic analysis and a shorter bleeding time compared with a conventional 19-gauge FNA needle in the animal model. It is a promising new technique for histologic examination of pancreatic tissue.
AB - BACKGROUND: EUS-guided FNA (EUS-FNA) is an established technique for the cytologic diagnosis of pancreatic disease. Attempts to obtain adequate histologic specimens have yielded variable and mostly insufficient results.OBJECTIVE: To evaluate the safety, feasibility, and quality of histologic biopsy specimens obtained by using a new cryobiopsy probe and to compare them with standard EUS-FNA and (laparoscopic) trucut biopsy specimens of pancreatic tissue.DESIGN: Animal non-survival study.INTERVENTION: Eighty-four pancreatic biopsy specimens (12 per group) were obtained in 4 anesthetized pigs by using one of the following the 18-gauge flexible cryoprobe; a conventional, 19-gauge, EUS-FNA needle; or a rigid, trucut biopsy device (18 gauge). The latter, used in laparoscopic surgery, was considered as the criterion standard for obtaining histology specimens.MAIN OUTCOME MEASUREMENTS: Specimens were evaluated for artifacts and specimen quality by a blinded pathologist who used a 7-point Likert scale to assess histologic adequacy. Biopsy size and bleeding time after biopsy also were recorded.RESULTS: The new cryoprobe was equivalent to the rigid, trucut needle and superior (P < .001) to the conventional 19-gauge FNA needles with respect to artifacts, quality of the specimen, biopsy specimen size, and bleeding.LIMITATIONS: Animal model.CONCLUSION: EUS-guided cryobiopsy was associated with better specimen quality for histologic analysis and a shorter bleeding time compared with a conventional 19-gauge FNA needle in the animal model. It is a promising new technique for histologic examination of pancreatic tissue.
KW - Animals
KW - Artifacts
KW - Cadaver
KW - Cold Temperature
KW - Endoscopic Ultrasound-Guided Fine Needle Aspiration
KW - Humans
KW - Pancreas
KW - Postoperative Hemorrhage
KW - Prospective Studies
KW - Single-Blind Method
KW - Swine
KW - Time Factors
U2 - 10.1016/j.gie.2012.12.013
DO - 10.1016/j.gie.2012.12.013
M3 - SCORING: Journal article
C2 - 23453293
VL - 77
SP - 784
EP - 792
JO - GASTROINTEST ENDOSC
JF - GASTROINTEST ENDOSC
SN - 0016-5107
IS - 5
ER -
