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A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin

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A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin. / Rhiemeier, Verena; Breitenbach, Ute; Richter, Karl Hartmut; Gebhardt, Christoffer; Vogt, Ingeborg; Hartenstein, Bettina; Fürstenberger, Gerhard; Mauch, Cornelia; Hess, Jochen; Angel, Peter.

in: AM J PATHOL, Jahrgang 168, Nr. 4, 04.2006, S. 1354-64.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rhiemeier, V, Breitenbach, U, Richter, KH, Gebhardt, C, Vogt, I, Hartenstein, B, Fürstenberger, G, Mauch, C, Hess, J & Angel, P 2006, 'A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin', AM J PATHOL, Jg. 168, Nr. 4, S. 1354-64. https://doi.org/10.2353/ajpath.2006.050871

APA

Rhiemeier, V., Breitenbach, U., Richter, K. H., Gebhardt, C., Vogt, I., Hartenstein, B., Fürstenberger, G., Mauch, C., Hess, J., & Angel, P. (2006). A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin. AM J PATHOL, 168(4), 1354-64. https://doi.org/10.2353/ajpath.2006.050871

Vancouver

Rhiemeier V, Breitenbach U, Richter KH, Gebhardt C, Vogt I, Hartenstein B et al. A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin. AM J PATHOL. 2006 Apr;168(4):1354-64. https://doi.org/10.2353/ajpath.2006.050871

Bibtex

@article{07d8a3570d7442faa04c4411d5f69570,
title = "A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin",
abstract = "Homeostasis of stratified epithelia, such as the epidermis of the skin, is a sophisticated process that represents a tightly controlled balance between proliferation and differentiation. Alterations of this balance are associated with common human diseases including cancer. Here, we report the cloning of a novel cDNA sequence, from mouse back skin, that is induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and codes for a hitherto unknown aspartic proteinase-like protein (Taps). Taps represents a potential AP-1 target gene because TPA-induced expression in epidermal keratinocytes critically depends on c-Fos, and co-treatment with dexamethasone, a potent inhibitor of AP-1-mediated gene regulation, resulted in impaired activation of Taps expression. Taps mRNA and protein are restricted to stratified epithelia in mouse embryos and adult tissues, implicating a crucial role for this aspartic proteinase-like gene in differentiation and homeostasis of multilayered epithelia. During chemically induced carcinogenesis, transient elevation of Taps mRNA and protein levels was detected in benign skin tumors. However, its expression is negatively associated with dedifferentiation and malignant progression in squamous cell carcinomas of the skin. Similar expression was observed in squamous skin tumors of patients, suggesting that detection of Taps levels represents a novel strategy to discriminate the progression state of squamous skin cancers.",
keywords = "Amino Acid Sequence, Animals, Aspartic Acid Endopeptidases, Carcinoma, Squamous Cell, Cell Differentiation, Cell Line, Tumor, Dexamethasone, Epidermis, Epithelium, Female, Gene Expression Regulation, Developmental, Gene Expression Regulation, Neoplastic, Genes, fos, Humans, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Skin, Skin Neoplasms, Tetradecanoylphorbol Acetate, Transcription Factor AP-1, Journal Article, Research Support, Non-U.S. Gov't",
author = "Verena Rhiemeier and Ute Breitenbach and Richter, {Karl Hartmut} and Christoffer Gebhardt and Ingeborg Vogt and Bettina Hartenstein and Gerhard F{\"u}rstenberger and Cornelia Mauch and Jochen Hess and Peter Angel",
year = "2006",
month = apr,
doi = "10.2353/ajpath.2006.050871",
language = "English",
volume = "168",
pages = "1354--64",
journal = "AM J PATHOL",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin

AU - Rhiemeier, Verena

AU - Breitenbach, Ute

AU - Richter, Karl Hartmut

AU - Gebhardt, Christoffer

AU - Vogt, Ingeborg

AU - Hartenstein, Bettina

AU - Fürstenberger, Gerhard

AU - Mauch, Cornelia

AU - Hess, Jochen

AU - Angel, Peter

PY - 2006/4

Y1 - 2006/4

N2 - Homeostasis of stratified epithelia, such as the epidermis of the skin, is a sophisticated process that represents a tightly controlled balance between proliferation and differentiation. Alterations of this balance are associated with common human diseases including cancer. Here, we report the cloning of a novel cDNA sequence, from mouse back skin, that is induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and codes for a hitherto unknown aspartic proteinase-like protein (Taps). Taps represents a potential AP-1 target gene because TPA-induced expression in epidermal keratinocytes critically depends on c-Fos, and co-treatment with dexamethasone, a potent inhibitor of AP-1-mediated gene regulation, resulted in impaired activation of Taps expression. Taps mRNA and protein are restricted to stratified epithelia in mouse embryos and adult tissues, implicating a crucial role for this aspartic proteinase-like gene in differentiation and homeostasis of multilayered epithelia. During chemically induced carcinogenesis, transient elevation of Taps mRNA and protein levels was detected in benign skin tumors. However, its expression is negatively associated with dedifferentiation and malignant progression in squamous cell carcinomas of the skin. Similar expression was observed in squamous skin tumors of patients, suggesting that detection of Taps levels represents a novel strategy to discriminate the progression state of squamous skin cancers.

AB - Homeostasis of stratified epithelia, such as the epidermis of the skin, is a sophisticated process that represents a tightly controlled balance between proliferation and differentiation. Alterations of this balance are associated with common human diseases including cancer. Here, we report the cloning of a novel cDNA sequence, from mouse back skin, that is induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and codes for a hitherto unknown aspartic proteinase-like protein (Taps). Taps represents a potential AP-1 target gene because TPA-induced expression in epidermal keratinocytes critically depends on c-Fos, and co-treatment with dexamethasone, a potent inhibitor of AP-1-mediated gene regulation, resulted in impaired activation of Taps expression. Taps mRNA and protein are restricted to stratified epithelia in mouse embryos and adult tissues, implicating a crucial role for this aspartic proteinase-like gene in differentiation and homeostasis of multilayered epithelia. During chemically induced carcinogenesis, transient elevation of Taps mRNA and protein levels was detected in benign skin tumors. However, its expression is negatively associated with dedifferentiation and malignant progression in squamous cell carcinomas of the skin. Similar expression was observed in squamous skin tumors of patients, suggesting that detection of Taps levels represents a novel strategy to discriminate the progression state of squamous skin cancers.

KW - Amino Acid Sequence

KW - Animals

KW - Aspartic Acid Endopeptidases

KW - Carcinoma, Squamous Cell

KW - Cell Differentiation

KW - Cell Line, Tumor

KW - Dexamethasone

KW - Epidermis

KW - Epithelium

KW - Female

KW - Gene Expression Regulation, Developmental

KW - Gene Expression Regulation, Neoplastic

KW - Genes, fos

KW - Humans

KW - Mice

KW - Mice, Inbred C57BL

KW - Molecular Sequence Data

KW - Skin

KW - Skin Neoplasms

KW - Tetradecanoylphorbol Acetate

KW - Transcription Factor AP-1

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.2353/ajpath.2006.050871

DO - 10.2353/ajpath.2006.050871

M3 - SCORING: Journal article

C2 - 16565508

VL - 168

SP - 1354

EP - 1364

JO - AM J PATHOL

JF - AM J PATHOL

SN - 0002-9440

IS - 4

ER -