A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae

Bibi Nusreen Imambocus; Fangmin Zhou; Andrey Formozov; Annika Wittich; Federico M Tenedini; Chun Hu; Kathrin Sauter; Ednilson Macarenhas Varela; Fabiana Herédia; Andreia P Casimiro; André Macedo; Philipp Schlegel; Chung-Hui Yang; Irene Miguel-Aliaga; J Simon Wiegert; Michael J Pankratz; Alisson M Gontijo; Albert Cardona; Peter Soba

doi:10.1016/j.cub.2021.10.069

A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae

Standard

A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. / Imambocus, Bibi Nusreen; Zhou, Fangmin; Formozov, Andrey; Wittich, Annika; Tenedini, Federico M; Hu, Chun; Sauter, Kathrin; Macarenhas Varela, Ednilson; Herédia, Fabiana; Casimiro, Andreia P; Macedo, André; Schlegel, Philipp; Yang, Chung-Hui; Miguel-Aliaga, Irene; Wiegert, J Simon; Pankratz, Michael J; Gontijo, Alisson M; Cardona, Albert; Soba, Peter.

in: CURR BIOL, Jahrgang 32, Nr. 1, 10.01.2022, S. 149-163.e8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Imambocus, BN, Zhou, F, Formozov, A, Wittich, A, Tenedini, FM, Hu, C, Sauter, K, Macarenhas Varela, E, Herédia, F, Casimiro, AP, Macedo, A, Schlegel, P, Yang, C-H, Miguel-Aliaga, I, Wiegert, JS, Pankratz, MJ, Gontijo, AM, Cardona, A & Soba, P 2022, 'A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae', CURR BIOL, Jg. 32, Nr. 1, S. 149-163.e8. https://doi.org/10.1016/j.cub.2021.10.069

APA

Imambocus, B. N., Zhou, F., Formozov, A., Wittich, A., Tenedini, F. M., Hu, C., Sauter, K., Macarenhas Varela, E., Herédia, F., Casimiro, A. P., Macedo, A., Schlegel, P., Yang, C-H., Miguel-Aliaga, I., Wiegert, J. S., Pankratz, M. J., Gontijo, A. M., Cardona, A., & Soba, P. (2022). A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. CURR BIOL, 32(1), 149-163.e8. https://doi.org/10.1016/j.cub.2021.10.069

Vancouver

Imambocus BN, Zhou F, Formozov A, Wittich A, Tenedini FM, Hu C et al. A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. CURR BIOL. 2022 Jan 10;32(1):149-163.e8. https://doi.org/10.1016/j.cub.2021.10.069

Bibtex

@article{b73f9d174fe9435dbe371bc1f9c15f84,

title = "A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae",

abstract = "Animals display selective escape behaviors when faced with environmental threats. Selection of the appropriate response by the underlying neuronal network is key to maximizing chances of survival, yet the underlying network mechanisms are so far not fully understood. Using synapse-level reconstruction of the Drosophila larval network paired with physiological and behavioral readouts, we uncovered a circuit that gates selective escape behavior for noxious light through acute and input-specific neuropeptide action. Sensory neurons required for avoidance of noxious light and escape in response to harsh touch, each converge on discrete domains of neuromodulatory hub neurons. We show that acute release of hub neuron-derived insulin-like peptide 7 (Ilp7) and cognate relaxin family receptor (Lgr4) signaling in downstream neurons are required for noxious light avoidance, but not harsh touch responses. Our work highlights a role for compartmentalized circuit organization and neuropeptide release from regulatory hubs, acting as central circuit elements gating escape responses.",

author = "Imambocus, {Bibi Nusreen} and Fangmin Zhou and Andrey Formozov and Annika Wittich and Tenedini, {Federico M} and Chun Hu and Kathrin Sauter and {Macarenhas Varela}, Ednilson and Fabiana Her{\'e}dia and Casimiro, {Andreia P} and Andr{\'e} Macedo and Philipp Schlegel and Chung-Hui Yang and Irene Miguel-Aliaga and Wiegert, {J Simon} and Pankratz, {Michael J} and Gontijo, {Alisson M} and Albert Cardona and Peter Soba",

year = "2022",

month = jan,

day = "10",

doi = "10.1016/j.cub.2021.10.069",

language = "English",

volume = "32",

pages = "149--163.e8",

journal = "CURR BIOL",

issn = "0960-9822",

publisher = "Cell Press",

number = "1",

}

RIS

TY - JOUR

T1 - A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae

AU - Imambocus, Bibi Nusreen

AU - Zhou, Fangmin

AU - Formozov, Andrey

AU - Wittich, Annika

AU - Tenedini, Federico M

AU - Hu, Chun

AU - Sauter, Kathrin

AU - Macarenhas Varela, Ednilson

AU - Herédia, Fabiana

AU - Casimiro, Andreia P

AU - Macedo, André

AU - Schlegel, Philipp

AU - Yang, Chung-Hui

AU - Miguel-Aliaga, Irene

AU - Wiegert, J Simon

AU - Pankratz, Michael J

AU - Gontijo, Alisson M

AU - Cardona, Albert

AU - Soba, Peter

PY - 2022/1/10

Y1 - 2022/1/10

N2 - Animals display selective escape behaviors when faced with environmental threats. Selection of the appropriate response by the underlying neuronal network is key to maximizing chances of survival, yet the underlying network mechanisms are so far not fully understood. Using synapse-level reconstruction of the Drosophila larval network paired with physiological and behavioral readouts, we uncovered a circuit that gates selective escape behavior for noxious light through acute and input-specific neuropeptide action. Sensory neurons required for avoidance of noxious light and escape in response to harsh touch, each converge on discrete domains of neuromodulatory hub neurons. We show that acute release of hub neuron-derived insulin-like peptide 7 (Ilp7) and cognate relaxin family receptor (Lgr4) signaling in downstream neurons are required for noxious light avoidance, but not harsh touch responses. Our work highlights a role for compartmentalized circuit organization and neuropeptide release from regulatory hubs, acting as central circuit elements gating escape responses.

AB - Animals display selective escape behaviors when faced with environmental threats. Selection of the appropriate response by the underlying neuronal network is key to maximizing chances of survival, yet the underlying network mechanisms are so far not fully understood. Using synapse-level reconstruction of the Drosophila larval network paired with physiological and behavioral readouts, we uncovered a circuit that gates selective escape behavior for noxious light through acute and input-specific neuropeptide action. Sensory neurons required for avoidance of noxious light and escape in response to harsh touch, each converge on discrete domains of neuromodulatory hub neurons. We show that acute release of hub neuron-derived insulin-like peptide 7 (Ilp7) and cognate relaxin family receptor (Lgr4) signaling in downstream neurons are required for noxious light avoidance, but not harsh touch responses. Our work highlights a role for compartmentalized circuit organization and neuropeptide release from regulatory hubs, acting as central circuit elements gating escape responses.

U2 - 10.1016/j.cub.2021.10.069

DO - 10.1016/j.cub.2021.10.069

M3 - SCORING: Journal article

C2 - 34798050

VL - 32

SP - 149-163.e8

JO - CURR BIOL

JF - CURR BIOL

SN - 0960-9822

IS - 1

ER -