A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
Standard
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. / Escala-Garcia, Maria; Abraham, Jean; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Ashworth, Alan; Auer, Paul L; Auvinen, Päivi; Beesley, Jonathan; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Blot, William; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Børresen-Dale, Anne-Lise; Brauch, Hiltrud; Brenner, Hermann; Brucker, Sara Y; Burwinkel, Barbara; Caldas, Carlos; Canzian, Federico; Chang-Claude, Jenny; Chanock, Stephen J; Chin, Suet-Feung; Clarke, Christine L; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Daly, Mary B; Dennis, Joe; Devilee, Peter; Dunn, Janet A; Dunning, Alison M; Dwek, Miriam; Earl, Helena M; Eccles, Diana M; Eliassen, A Heather; Ellberg, Carolina; Evans, D Gareth; Fasching, Peter A; Figueroa, Jonine; Flyger, Henrik; Gago-Dominguez, Manuela; Gapstur, Susan M; García-Closas, Montserrat; García-Sáenz, José A; Gaudet, Mia M; George, Angela; Giles, Graham G; Goldgar, David E; González-Neira, Anna; Grip, Mervi; Guénel, Pascal; Guo, Qi; Haiman, Christopher A; Håkansson, Niclas; Hamann, Ute; Harrington, Patricia A; Hiller, Louise; Hooning, Maartje J; Hopper, John L; Howell, Anthony; Huang, Chiun-Sheng; Huang, Guanmengqian; Hunter, David J; Jakubowska, Anna; John, Esther M; Kaaks, Rudolf; Kapoor, Pooja Middha; Keeman, Renske; Kitahara, Cari M; Koppert, Linetta B; Kraft, Peter; Kristensen, Vessela N; Lambrechts, Diether; Le Marchand, Loic; Lejbkowicz, Flavio; Lindblom, Annika; Lubiński, Jan; Mannermaa, Arto; Manoochehri, Mehdi; Manoukian, Siranoush; Margolin, Sara; Martinez, Maria Elena; Maurer, Tabea; Mavroudis, Dimitrios; Meindl, Alfons; Milne, Roger L; Mulligan, Anna Marie; Neuhausen, Susan L; Nevanlinna, Heli; Newman, William G; Olshan, Andrew F; Olson, Janet E; Olsson, Håkan; Orr, Nick; Peterlongo, Paolo; Petridis, Christos; Prentice, Ross L; Presneau, Nadege; Punie, Kevin; Ramachandran, Dhanya; Rennert, Gad; Romero, Atocha; Sachchithananthan, Mythily; Saloustros, Emmanouil; Sawyer, Elinor J; Schmutzler, Rita K; Schwentner, Lukas; Scott, Christopher; Simard, Jacques; Sohn, Christof; Southey, Melissa C; Swerdlow, Anthony J; Tamimi, Rulla M; Tapper, William J; Teixeira, Manuel R; Terry, Mary Beth; Thorne, Heather; Tollenaar, Rob A E M; Tomlinson, Ian; Troester, Melissa A; Truong, Thérèse; Turnbull, Clare; Vachon, Celine M; van der Kolk, Lizet E; Wang, Qin; Winqvist, Robert; Wolk, Alicja; Yang, Xiaohong R; Ziogas, Argyrios; Pharoah, Paul D P; Hall, Per; Wessels, Lodewyk F A; Chenevix-Trench, Georgia; Bader, Gary D; Dörk, Thilo; Easton, Douglas F; Canisius, Sander; Schmidt, Marjanka K; Breast Cancer Association Consortium (BCAC).
in: NAT COMMUN, Jahrgang 11, Nr. 1, 16.01.2020, S. 312.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
AU - Escala-Garcia, Maria
AU - Abraham, Jean
AU - Andrulis, Irene L
AU - Anton-Culver, Hoda
AU - Arndt, Volker
AU - Ashworth, Alan
AU - Auer, Paul L
AU - Auvinen, Päivi
AU - Beesley, Jonathan
AU - Behrens, Sabine
AU - Benitez, Javier
AU - Bermisheva, Marina
AU - Blomqvist, Carl
AU - Blot, William
AU - Bogdanova, Natalia V
AU - Bojesen, Stig E
AU - Bolla, Manjeet K
AU - Børresen-Dale, Anne-Lise
AU - Brauch, Hiltrud
AU - Brenner, Hermann
AU - Brucker, Sara Y
AU - Burwinkel, Barbara
AU - Caldas, Carlos
AU - Canzian, Federico
AU - Chang-Claude, Jenny
AU - Chanock, Stephen J
AU - Chin, Suet-Feung
AU - Clarke, Christine L
AU - Couch, Fergus J
AU - Cox, Angela
AU - Cross, Simon S
AU - Czene, Kamila
AU - Daly, Mary B
AU - Dennis, Joe
AU - Devilee, Peter
AU - Dunn, Janet A
AU - Dunning, Alison M
AU - Dwek, Miriam
AU - Earl, Helena M
AU - Eccles, Diana M
AU - Eliassen, A Heather
AU - Ellberg, Carolina
AU - Evans, D Gareth
AU - Fasching, Peter A
AU - Figueroa, Jonine
AU - Flyger, Henrik
AU - Gago-Dominguez, Manuela
AU - Gapstur, Susan M
AU - García-Closas, Montserrat
AU - García-Sáenz, José A
AU - Gaudet, Mia M
AU - George, Angela
AU - Giles, Graham G
AU - Goldgar, David E
AU - González-Neira, Anna
AU - Grip, Mervi
AU - Guénel, Pascal
AU - Guo, Qi
AU - Haiman, Christopher A
AU - Håkansson, Niclas
AU - Hamann, Ute
AU - Harrington, Patricia A
AU - Hiller, Louise
AU - Hooning, Maartje J
AU - Hopper, John L
AU - Howell, Anthony
AU - Huang, Chiun-Sheng
AU - Huang, Guanmengqian
AU - Hunter, David J
AU - Jakubowska, Anna
AU - John, Esther M
AU - Kaaks, Rudolf
AU - Kapoor, Pooja Middha
AU - Keeman, Renske
AU - Kitahara, Cari M
AU - Koppert, Linetta B
AU - Kraft, Peter
AU - Kristensen, Vessela N
AU - Lambrechts, Diether
AU - Le Marchand, Loic
AU - Lejbkowicz, Flavio
AU - Lindblom, Annika
AU - Lubiński, Jan
AU - Mannermaa, Arto
AU - Manoochehri, Mehdi
AU - Manoukian, Siranoush
AU - Margolin, Sara
AU - Martinez, Maria Elena
AU - Maurer, Tabea
AU - Mavroudis, Dimitrios
AU - Meindl, Alfons
AU - Milne, Roger L
AU - Mulligan, Anna Marie
AU - Neuhausen, Susan L
AU - Nevanlinna, Heli
AU - Newman, William G
AU - Olshan, Andrew F
AU - Olson, Janet E
AU - Olsson, Håkan
AU - Orr, Nick
AU - Peterlongo, Paolo
AU - Petridis, Christos
AU - Prentice, Ross L
AU - Presneau, Nadege
AU - Punie, Kevin
AU - Ramachandran, Dhanya
AU - Rennert, Gad
AU - Romero, Atocha
AU - Sachchithananthan, Mythily
AU - Saloustros, Emmanouil
AU - Sawyer, Elinor J
AU - Schmutzler, Rita K
AU - Schwentner, Lukas
AU - Scott, Christopher
AU - Simard, Jacques
AU - Sohn, Christof
AU - Southey, Melissa C
AU - Swerdlow, Anthony J
AU - Tamimi, Rulla M
AU - Tapper, William J
AU - Teixeira, Manuel R
AU - Terry, Mary Beth
AU - Thorne, Heather
AU - Tollenaar, Rob A E M
AU - Tomlinson, Ian
AU - Troester, Melissa A
AU - Truong, Thérèse
AU - Turnbull, Clare
AU - Vachon, Celine M
AU - van der Kolk, Lizet E
AU - Wang, Qin
AU - Winqvist, Robert
AU - Wolk, Alicja
AU - Yang, Xiaohong R
AU - Ziogas, Argyrios
AU - Pharoah, Paul D P
AU - Hall, Per
AU - Wessels, Lodewyk F A
AU - Chenevix-Trench, Georgia
AU - Bader, Gary D
AU - Dörk, Thilo
AU - Easton, Douglas F
AU - Canisius, Sander
AU - Schmidt, Marjanka K
AU - Breast Cancer Association Consortium (BCAC)
PY - 2020/1/16
Y1 - 2020/1/16
N2 - Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
AB - Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
KW - Apoptosis
KW - Breast Neoplasms/genetics
KW - Circadian Clocks
KW - Computational Biology
KW - Female
KW - GTP-Binding Protein alpha Subunits/genetics
KW - GTP-Binding Protein alpha Subunits, Gq-G11/genetics
KW - Gene Regulatory Networks
KW - Genetic Variation
KW - Genome-Wide Association Study
KW - Genotype
KW - Germ Cells
KW - Humans
KW - Prognosis
KW - Receptors, Estrogen/genetics
KW - Signal Transduction
U2 - 10.1038/s41467-019-14100-6
DO - 10.1038/s41467-019-14100-6
M3 - SCORING: Journal article
C2 - 31949161
VL - 11
SP - 312
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
IS - 1
ER -