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A Multi-Institutional Validation of Gleason Score Derived from Tissue Microarray Cores

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A Multi-Institutional Validation of Gleason Score Derived from Tissue Microarray Cores. / Leyh-Bannurah, Sami-Ramzi; Trudel, Dominique; Latour, Mathieu; Zaffuto, Emanuele; Grosset, Andree-Anne; Tam, Christine; Ouellet, Veronique; Graefen, Markus; Budäus, Lars; Aprikian, Armen G; Lacombe, Louis; Fleshner, Neil E; Gleave, Martin E; Mes-Masson, Anne-Marie; Saad, Fred; Karakiewicz, Pierre I.

in: PATHOL ONCOL RES, Jahrgang 25, Nr. 3, 07.2019, S. 979-986.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Leyh-Bannurah, S-R, Trudel, D, Latour, M, Zaffuto, E, Grosset, A-A, Tam, C, Ouellet, V, Graefen, M, Budäus, L, Aprikian, AG, Lacombe, L, Fleshner, NE, Gleave, ME, Mes-Masson, A-M, Saad, F & Karakiewicz, PI 2019, 'A Multi-Institutional Validation of Gleason Score Derived from Tissue Microarray Cores', PATHOL ONCOL RES, Jg. 25, Nr. 3, S. 979-986. https://doi.org/10.1007/s12253-018-0408-6

APA

Leyh-Bannurah, S-R., Trudel, D., Latour, M., Zaffuto, E., Grosset, A-A., Tam, C., Ouellet, V., Graefen, M., Budäus, L., Aprikian, A. G., Lacombe, L., Fleshner, N. E., Gleave, M. E., Mes-Masson, A-M., Saad, F., & Karakiewicz, P. I. (2019). A Multi-Institutional Validation of Gleason Score Derived from Tissue Microarray Cores. PATHOL ONCOL RES, 25(3), 979-986. https://doi.org/10.1007/s12253-018-0408-6

Vancouver

Leyh-Bannurah S-R, Trudel D, Latour M, Zaffuto E, Grosset A-A, Tam C et al. A Multi-Institutional Validation of Gleason Score Derived from Tissue Microarray Cores. PATHOL ONCOL RES. 2019 Jul;25(3):979-986. https://doi.org/10.1007/s12253-018-0408-6

Bibtex

@article{132dcbe767d547098808ba340f0516ac,
title = "A Multi-Institutional Validation of Gleason Score Derived from Tissue Microarray Cores",
abstract = "To test the agreement between high-grade PCa at RP and TMA, and the ability of TMA to predict BCR. Validation of concordance between tissue microarray (TMA) and radical prostatectomy (RP) high-grade prostate cancer (PCa) is crucial because latter determines the treated natural history of PCa. We hypothesized that TMA Gleason score is in agreement with RP pathology and capable of accurately predicting biochemical recurrence (BCR). Data were provided from a multi-institutional Canadian sample of 1333 TMA and RP specimens with complete clinicopathological data. First, rate of agreement between TMA and high-grade Gleason at RP or biopsy and RP was tested. Second, ability of RP, TMA and biopsy to predict BCR was compared. Multivariable (MVA) Cox regression models were fitted and BCR rates were illustrated with Kaplan-Meier plots. Agreement between RP and TMA and between RP and biopsy was 72.6% (95% CI:69.7-75.5) and 60.4% (95% CI:57.2-63.6), respectively. In MVA predicting BCR, the accuracy for RP, TMA and biopsy was 0.73, 0.72 and 0.68, respectively. TMA added discriminatory ability among exclusively low-grade Gleason RP patients (p = 0.02), but did not improve BCR discrimination in exclusive high-grade PCa RP patients (p = 0.8). TMA Gleason grade accurately reflects presence of high-grade Gleason in RP specimen, accurately predicts BCR rates after RP and improves prediction of BCR in low-grade Gleason patients at RP.",
keywords = "Journal Article",
author = "Sami-Ramzi Leyh-Bannurah and Dominique Trudel and Mathieu Latour and Emanuele Zaffuto and Andree-Anne Grosset and Christine Tam and Veronique Ouellet and Markus Graefen and Lars Bud{\"a}us and Aprikian, {Armen G} and Louis Lacombe and Fleshner, {Neil E} and Gleave, {Martin E} and Anne-Marie Mes-Masson and Fred Saad and Karakiewicz, {Pierre I}",
year = "2019",
month = jul,
doi = "10.1007/s12253-018-0408-6",
language = "English",
volume = "25",
pages = "979--986",
journal = "PATHOL ONCOL RES",
issn = "1219-4956",
publisher = "Springer Netherlands",
number = "3",

}

RIS

TY - JOUR

T1 - A Multi-Institutional Validation of Gleason Score Derived from Tissue Microarray Cores

AU - Leyh-Bannurah, Sami-Ramzi

AU - Trudel, Dominique

AU - Latour, Mathieu

AU - Zaffuto, Emanuele

AU - Grosset, Andree-Anne

AU - Tam, Christine

AU - Ouellet, Veronique

AU - Graefen, Markus

AU - Budäus, Lars

AU - Aprikian, Armen G

AU - Lacombe, Louis

AU - Fleshner, Neil E

AU - Gleave, Martin E

AU - Mes-Masson, Anne-Marie

AU - Saad, Fred

AU - Karakiewicz, Pierre I

PY - 2019/7

Y1 - 2019/7

N2 - To test the agreement between high-grade PCa at RP and TMA, and the ability of TMA to predict BCR. Validation of concordance between tissue microarray (TMA) and radical prostatectomy (RP) high-grade prostate cancer (PCa) is crucial because latter determines the treated natural history of PCa. We hypothesized that TMA Gleason score is in agreement with RP pathology and capable of accurately predicting biochemical recurrence (BCR). Data were provided from a multi-institutional Canadian sample of 1333 TMA and RP specimens with complete clinicopathological data. First, rate of agreement between TMA and high-grade Gleason at RP or biopsy and RP was tested. Second, ability of RP, TMA and biopsy to predict BCR was compared. Multivariable (MVA) Cox regression models were fitted and BCR rates were illustrated with Kaplan-Meier plots. Agreement between RP and TMA and between RP and biopsy was 72.6% (95% CI:69.7-75.5) and 60.4% (95% CI:57.2-63.6), respectively. In MVA predicting BCR, the accuracy for RP, TMA and biopsy was 0.73, 0.72 and 0.68, respectively. TMA added discriminatory ability among exclusively low-grade Gleason RP patients (p = 0.02), but did not improve BCR discrimination in exclusive high-grade PCa RP patients (p = 0.8). TMA Gleason grade accurately reflects presence of high-grade Gleason in RP specimen, accurately predicts BCR rates after RP and improves prediction of BCR in low-grade Gleason patients at RP.

AB - To test the agreement between high-grade PCa at RP and TMA, and the ability of TMA to predict BCR. Validation of concordance between tissue microarray (TMA) and radical prostatectomy (RP) high-grade prostate cancer (PCa) is crucial because latter determines the treated natural history of PCa. We hypothesized that TMA Gleason score is in agreement with RP pathology and capable of accurately predicting biochemical recurrence (BCR). Data were provided from a multi-institutional Canadian sample of 1333 TMA and RP specimens with complete clinicopathological data. First, rate of agreement between TMA and high-grade Gleason at RP or biopsy and RP was tested. Second, ability of RP, TMA and biopsy to predict BCR was compared. Multivariable (MVA) Cox regression models were fitted and BCR rates were illustrated with Kaplan-Meier plots. Agreement between RP and TMA and between RP and biopsy was 72.6% (95% CI:69.7-75.5) and 60.4% (95% CI:57.2-63.6), respectively. In MVA predicting BCR, the accuracy for RP, TMA and biopsy was 0.73, 0.72 and 0.68, respectively. TMA added discriminatory ability among exclusively low-grade Gleason RP patients (p = 0.02), but did not improve BCR discrimination in exclusive high-grade PCa RP patients (p = 0.8). TMA Gleason grade accurately reflects presence of high-grade Gleason in RP specimen, accurately predicts BCR rates after RP and improves prediction of BCR in low-grade Gleason patients at RP.

KW - Journal Article

U2 - 10.1007/s12253-018-0408-6

DO - 10.1007/s12253-018-0408-6

M3 - SCORING: Journal article

C2 - 29623528

VL - 25

SP - 979

EP - 986

JO - PATHOL ONCOL RES

JF - PATHOL ONCOL RES

SN - 1219-4956

IS - 3

ER -