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A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial

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A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial. / Zülke, Andrea E.; Pabst, Alexander; Luppa, Melanie; Roehr, Susanne; Seidling, Hanna; Oey, Anke; Cardona, Maria Isabel; Blotenberg, Iris; Bauer, Alexander; Weise, Solveig; Zöllinger, Isabel; Sanftenberg, Linda; Brettschneider, Christian; Döhring, Juliane; Lunden, Laura; Czock, David; Haefeli, Walter E.; Wiese, Birgitt; Hoffmann, Wolfgang; Frese, Thomas; Gensichen, Jochen; König, Hans-Helmut; Kaduszkiewicz, Hanna; Thyrian, Jochen René; Riedel-Heller, Steffi G.

in: ALZHEIMERS DEMENT, Jahrgang 20, Nr. 1, 01.2024, S. 615-628.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Zülke, AE, Pabst, A, Luppa, M, Roehr, S, Seidling, H, Oey, A, Cardona, MI, Blotenberg, I, Bauer, A, Weise, S, Zöllinger, I, Sanftenberg, L, Brettschneider, C, Döhring, J, Lunden, L, Czock, D, Haefeli, WE, Wiese, B, Hoffmann, W, Frese, T, Gensichen, J, König, H-H, Kaduszkiewicz, H, Thyrian, JR & Riedel-Heller, SG 2024, 'A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial', ALZHEIMERS DEMENT, Jg. 20, Nr. 1, S. 615-628. https://doi.org/10.1002/alz.13486

APA

Zülke, A. E., Pabst, A., Luppa, M., Roehr, S., Seidling, H., Oey, A., Cardona, M. I., Blotenberg, I., Bauer, A., Weise, S., Zöllinger, I., Sanftenberg, L., Brettschneider, C., Döhring, J., Lunden, L., Czock, D., Haefeli, W. E., Wiese, B., Hoffmann, W., ... Riedel-Heller, S. G. (2024). A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial. ALZHEIMERS DEMENT, 20(1), 615-628. https://doi.org/10.1002/alz.13486

Vancouver

Zülke AE, Pabst A, Luppa M, Roehr S, Seidling H, Oey A et al. A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial. ALZHEIMERS DEMENT. 2024 Jan;20(1):615-628. https://doi.org/10.1002/alz.13486

Bibtex

@article{59aa83db3d014441b339233136fdba77,
title = "A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial",
abstract = "INTRODUCTION: We investigated the effectiveness of a multidomain intervention to preserve cognitive function in older adults at risk for dementia in Germany in a cluster-randomized trial.METHODS: Individuals with a Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) risk score ≥ 9 aged 60 to 77 years were recruited. After randomization of their general practitioner (GP), patients received a multidomain intervention (including optimization of nutrition and medication, and physical, social, and cognitive activity) or general health advice and GP treatment as usual over 24 months. Primary outcome was global cognitive performance (composite z score, based on domain-specific neuropsychological tests).RESULTS: Of 1030 participants at baseline, n = 819 completed the 24-month follow-up assessment. No differences regarding global cognitive performance (average marginal effect = 0.010, 95% confidence interval: -0.113, 0.133) were found between groups at follow-up. Perceived restrictions in intervention conduct by the COVID-19 pandemic did not impact intervention effectiveness.DISCUSSION: The intervention did not improve global cognitive performance.HIGHLIGHTS: Overall, no intervention effects on global cognitive performance were detected. The multidomain intervention improved health-related quality of life in the total sample. In women, the multidomain intervention reduced depressive symptoms. The intervention was completed during the COVID-19 pandemic.",
keywords = "cognitive function, dementia, lifestyle, prevention, randomized controlled trial",
author = "Z{\"u}lke, {Andrea E.} and Alexander Pabst and Melanie Luppa and Susanne Roehr and Hanna Seidling and Anke Oey and Cardona, {Maria Isabel} and Iris Blotenberg and Alexander Bauer and Solveig Weise and Isabel Z{\"o}llinger and Linda Sanftenberg and Christian Brettschneider and Juliane D{\"o}hring and Laura Lunden and David Czock and Haefeli, {Walter E.} and Birgitt Wiese and Wolfgang Hoffmann and Thomas Frese and Jochen Gensichen and Hans-Helmut K{\"o}nig and Hanna Kaduszkiewicz and Thyrian, {Jochen Ren{\'e}} and Riedel-Heller, {Steffi G.}",
year = "2024",
month = jan,
doi = "10.1002/alz.13486",
language = "English",
volume = "20",
pages = "615--628",
journal = "ALZHEIMERS DEMENT",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial

AU - Zülke, Andrea E.

AU - Pabst, Alexander

AU - Luppa, Melanie

AU - Roehr, Susanne

AU - Seidling, Hanna

AU - Oey, Anke

AU - Cardona, Maria Isabel

AU - Blotenberg, Iris

AU - Bauer, Alexander

AU - Weise, Solveig

AU - Zöllinger, Isabel

AU - Sanftenberg, Linda

AU - Brettschneider, Christian

AU - Döhring, Juliane

AU - Lunden, Laura

AU - Czock, David

AU - Haefeli, Walter E.

AU - Wiese, Birgitt

AU - Hoffmann, Wolfgang

AU - Frese, Thomas

AU - Gensichen, Jochen

AU - König, Hans-Helmut

AU - Kaduszkiewicz, Hanna

AU - Thyrian, Jochen René

AU - Riedel-Heller, Steffi G.

PY - 2024/1

Y1 - 2024/1

N2 - INTRODUCTION: We investigated the effectiveness of a multidomain intervention to preserve cognitive function in older adults at risk for dementia in Germany in a cluster-randomized trial.METHODS: Individuals with a Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) risk score ≥ 9 aged 60 to 77 years were recruited. After randomization of their general practitioner (GP), patients received a multidomain intervention (including optimization of nutrition and medication, and physical, social, and cognitive activity) or general health advice and GP treatment as usual over 24 months. Primary outcome was global cognitive performance (composite z score, based on domain-specific neuropsychological tests).RESULTS: Of 1030 participants at baseline, n = 819 completed the 24-month follow-up assessment. No differences regarding global cognitive performance (average marginal effect = 0.010, 95% confidence interval: -0.113, 0.133) were found between groups at follow-up. Perceived restrictions in intervention conduct by the COVID-19 pandemic did not impact intervention effectiveness.DISCUSSION: The intervention did not improve global cognitive performance.HIGHLIGHTS: Overall, no intervention effects on global cognitive performance were detected. The multidomain intervention improved health-related quality of life in the total sample. In women, the multidomain intervention reduced depressive symptoms. The intervention was completed during the COVID-19 pandemic.

AB - INTRODUCTION: We investigated the effectiveness of a multidomain intervention to preserve cognitive function in older adults at risk for dementia in Germany in a cluster-randomized trial.METHODS: Individuals with a Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) risk score ≥ 9 aged 60 to 77 years were recruited. After randomization of their general practitioner (GP), patients received a multidomain intervention (including optimization of nutrition and medication, and physical, social, and cognitive activity) or general health advice and GP treatment as usual over 24 months. Primary outcome was global cognitive performance (composite z score, based on domain-specific neuropsychological tests).RESULTS: Of 1030 participants at baseline, n = 819 completed the 24-month follow-up assessment. No differences regarding global cognitive performance (average marginal effect = 0.010, 95% confidence interval: -0.113, 0.133) were found between groups at follow-up. Perceived restrictions in intervention conduct by the COVID-19 pandemic did not impact intervention effectiveness.DISCUSSION: The intervention did not improve global cognitive performance.HIGHLIGHTS: Overall, no intervention effects on global cognitive performance were detected. The multidomain intervention improved health-related quality of life in the total sample. In women, the multidomain intervention reduced depressive symptoms. The intervention was completed during the COVID-19 pandemic.

KW - cognitive function

KW - dementia

KW - lifestyle

KW - prevention

KW - randomized controlled trial

U2 - 10.1002/alz.13486

DO - 10.1002/alz.13486

M3 - SCORING: Journal article

C2 - 37768074

VL - 20

SP - 615

EP - 628

JO - ALZHEIMERS DEMENT

JF - ALZHEIMERS DEMENT

SN - 1552-5260

IS - 1

ER -