A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI

F Jessen; O Gür; W Block; G Ende; L Frölich; T Hammen; J Wiltfang; T Kucinski; H Jahn; R Heun; W Maier; H Kölsch; J Kornhuber; F Träber

doi:10.1212/WNL.0b013e3181a60a20

A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI

Standard

A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI. / Jessen, F; Gür, O; Block, W; Ende, G; Frölich, L; Hammen, T; Wiltfang, J; Kucinski, T; Jahn, H; Heun, R; Maier, W; Kölsch, H; Kornhuber, J; Träber, F.

in: NEUROLOGY, Jahrgang 72, Nr. 20, 19.05.2009, S. 1735-40.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jessen, F, Gür, O, Block, W, Ende, G, Frölich, L, Hammen, T, Wiltfang, J, Kucinski, T, Jahn, H, Heun, R, Maier, W, Kölsch, H, Kornhuber, J & Träber, F 2009, 'A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI', NEUROLOGY, Jg. 72, Nr. 20, S. 1735-40. https://doi.org/10.1212/WNL.0b013e3181a60a20

APA

Jessen, F., Gür, O., Block, W., Ende, G., Frölich, L., Hammen, T., Wiltfang, J., Kucinski, T., Jahn, H., Heun, R., Maier, W., Kölsch, H., Kornhuber, J., & Träber, F. (2009). A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI. NEUROLOGY, 72(20), 1735-40. https://doi.org/10.1212/WNL.0b013e3181a60a20

Vancouver

Jessen F, Gür O, Block W, Ende G, Frölich L, Hammen T et al. A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI. NEUROLOGY. 2009 Mai 19;72(20):1735-40. https://doi.org/10.1212/WNL.0b013e3181a60a20

Bibtex

@article{0582cdae9c654bdd9fbfa7a2038d3586,

title = "A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI",

abstract = "OBJECTIVE: The need for biological markers of Alzheimer disease (AD) is constantly increasing. Proton magnetic resonance spectroscopy ((1)H-MRS) studies have provided consistent evidence for a reduction of the neuronal marker N-acetylaspartate (NAA) in patients with AD. Within the German Competence Network on Dementia, we conducted a (1)H-MRS study in patients with mild dementia and mild cognitive impairment (MCI) at four sites to investigate the multicenter feasibility of (1)H-MRS.METHODS: In total, 130 patients with dementia (98 AD, 32 non-AD), 136 subjects with MCI (70 of AD type, 66 of non-AD type), and 45 unimpaired control subjects were included. Single-volume (1)H-MRS of the left medial temporal lobe was performed at long and short echo times. Metabolites were quantified and metabolic ratios were determined.RESULTS: We found a significant reduction of NAA concentration in patients with AD as compared to healthy volunteers and compared to patients with MCI of AD type. NAA/Cr (creatine/phosphocreatine) was also lower in patients with AD compared to control subjects. NAA, choline compounds, and Cr were lower in patients with AD compared to patients with non-AD dementia.CONCLUSIONS: We demonstrated the multicenter feasibility of proton magnetic resonance spectroscopy ((1)H-MRS) of the medial temporal lobe in mild dementia and mild cognitive impairment, which is a prerequisite for the application of (1)H-MRS in large-scale clinical trials. Since the concentration measures of the metabolites are adjusted for brain tissue volume, these findings are indicators of biochemical pathology beyond brain atrophy.",

keywords = "Aged, Alzheimer Disease, Aspartic Acid, Biomarkers, Cognition Disorders, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, Neuropsychological Tests, Temporal Lobe",

author = "F Jessen and O G{\"u}r and W Block and G Ende and L Fr{\"o}lich and T Hammen and J Wiltfang and T Kucinski and H Jahn and R Heun and W Maier and H K{\"o}lsch and J Kornhuber and F Tr{\"a}ber",

year = "2009",

month = may,

day = "19",

doi = "10.1212/WNL.0b013e3181a60a20",

language = "English",

volume = "72",

pages = "1735--40",

journal = "NEUROLOGY",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "20",

}

RIS

TY - JOUR

T1 - A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI

AU - Jessen, F

AU - Gür, O

AU - Block, W

AU - Ende, G

AU - Frölich, L

AU - Hammen, T

AU - Wiltfang, J

AU - Kucinski, T

AU - Jahn, H

AU - Heun, R

AU - Maier, W

AU - Kölsch, H

AU - Kornhuber, J

AU - Träber, F

PY - 2009/5/19

Y1 - 2009/5/19

N2 - OBJECTIVE: The need for biological markers of Alzheimer disease (AD) is constantly increasing. Proton magnetic resonance spectroscopy ((1)H-MRS) studies have provided consistent evidence for a reduction of the neuronal marker N-acetylaspartate (NAA) in patients with AD. Within the German Competence Network on Dementia, we conducted a (1)H-MRS study in patients with mild dementia and mild cognitive impairment (MCI) at four sites to investigate the multicenter feasibility of (1)H-MRS.METHODS: In total, 130 patients with dementia (98 AD, 32 non-AD), 136 subjects with MCI (70 of AD type, 66 of non-AD type), and 45 unimpaired control subjects were included. Single-volume (1)H-MRS of the left medial temporal lobe was performed at long and short echo times. Metabolites were quantified and metabolic ratios were determined.RESULTS: We found a significant reduction of NAA concentration in patients with AD as compared to healthy volunteers and compared to patients with MCI of AD type. NAA/Cr (creatine/phosphocreatine) was also lower in patients with AD compared to control subjects. NAA, choline compounds, and Cr were lower in patients with AD compared to patients with non-AD dementia.CONCLUSIONS: We demonstrated the multicenter feasibility of proton magnetic resonance spectroscopy ((1)H-MRS) of the medial temporal lobe in mild dementia and mild cognitive impairment, which is a prerequisite for the application of (1)H-MRS in large-scale clinical trials. Since the concentration measures of the metabolites are adjusted for brain tissue volume, these findings are indicators of biochemical pathology beyond brain atrophy.

AB - OBJECTIVE: The need for biological markers of Alzheimer disease (AD) is constantly increasing. Proton magnetic resonance spectroscopy ((1)H-MRS) studies have provided consistent evidence for a reduction of the neuronal marker N-acetylaspartate (NAA) in patients with AD. Within the German Competence Network on Dementia, we conducted a (1)H-MRS study in patients with mild dementia and mild cognitive impairment (MCI) at four sites to investigate the multicenter feasibility of (1)H-MRS.METHODS: In total, 130 patients with dementia (98 AD, 32 non-AD), 136 subjects with MCI (70 of AD type, 66 of non-AD type), and 45 unimpaired control subjects were included. Single-volume (1)H-MRS of the left medial temporal lobe was performed at long and short echo times. Metabolites were quantified and metabolic ratios were determined.RESULTS: We found a significant reduction of NAA concentration in patients with AD as compared to healthy volunteers and compared to patients with MCI of AD type. NAA/Cr (creatine/phosphocreatine) was also lower in patients with AD compared to control subjects. NAA, choline compounds, and Cr were lower in patients with AD compared to patients with non-AD dementia.CONCLUSIONS: We demonstrated the multicenter feasibility of proton magnetic resonance spectroscopy ((1)H-MRS) of the medial temporal lobe in mild dementia and mild cognitive impairment, which is a prerequisite for the application of (1)H-MRS in large-scale clinical trials. Since the concentration measures of the metabolites are adjusted for brain tissue volume, these findings are indicators of biochemical pathology beyond brain atrophy.

KW - Aged

KW - Alzheimer Disease

KW - Aspartic Acid

KW - Biomarkers

KW - Cognition Disorders

KW - Female

KW - Humans

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Middle Aged

KW - Neuropsychological Tests

KW - Temporal Lobe

U2 - 10.1212/WNL.0b013e3181a60a20

DO - 10.1212/WNL.0b013e3181a60a20

M3 - SCORING: Journal article

C2 - 19451528

VL - 72

SP - 1735

EP - 1740

JO - NEUROLOGY

JF - NEUROLOGY

SN - 0028-3878

IS - 20

ER -