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A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression

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A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression. / Brachet, Anna; Lario, Argentina; Fernández-Rodrigo, Alba; Heisler, Frank F; Gutiérrez, Yolanda; Lobo, Clara; Kneussel, Matthias; Esteban, José A.

in: CELL REP, Jahrgang 36, Nr. 5, 109499, 03.08.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Brachet, A, Lario, A, Fernández-Rodrigo, A, Heisler, FF, Gutiérrez, Y, Lobo, C, Kneussel, M & Esteban, JA 2021, 'A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression', CELL REP, Jg. 36, Nr. 5, 109499. https://doi.org/10.1016/j.celrep.2021.109499

APA

Brachet, A., Lario, A., Fernández-Rodrigo, A., Heisler, F. F., Gutiérrez, Y., Lobo, C., Kneussel, M., & Esteban, J. A. (2021). A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression. CELL REP, 36(5), [109499]. https://doi.org/10.1016/j.celrep.2021.109499

Vancouver

Brachet A, Lario A, Fernández-Rodrigo A, Heisler FF, Gutiérrez Y, Lobo C et al. A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression. CELL REP. 2021 Aug 3;36(5). 109499. https://doi.org/10.1016/j.celrep.2021.109499

Bibtex

@article{d212d04c861c4a82b66b50835da86d4f,
title = "A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression",
abstract = "The synaptic removal of AMPA-type glutamate receptors (AMPARs) is a core mechanism for hippocampal long-term depression (LTD). In this study, we address the role of microtubule-dependent transport of AMPARs as a driver for vesicular trafficking and sorting during LTD. Here, we show that the kinesin-1 motor KIF5A/C is strictly required for LTD expression in CA3-to-CA1 hippocampal synapses. Specifically, we find that KIF5 is required for an efficient internalization of AMPARs after NMDA receptor activation. We show that the KIF5/AMPAR complex is assembled in an activity-dependent manner and associates with microsomal membranes upon LTD induction. This interaction is facilitated by the vesicular adaptor protrudin, which is also required for LTD expression. We propose that protrudin links KIF5-dependent transport to endosomal sorting, preventing AMPAR recycling to synapses after LTD induction. Therefore, this work identifies an activity-dependent molecular motor and the vesicular adaptor protein that executes AMPAR synaptic removal during LTD.",
author = "Anna Brachet and Argentina Lario and Alba Fern{\'a}ndez-Rodrigo and Heisler, {Frank F} and Yolanda Guti{\'e}rrez and Clara Lobo and Matthias Kneussel and Esteban, {Jos{\'e} A}",
note = "Copyright {\textcopyright} 2021 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2021",
month = aug,
day = "3",
doi = "10.1016/j.celrep.2021.109499",
language = "English",
volume = "36",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression

AU - Brachet, Anna

AU - Lario, Argentina

AU - Fernández-Rodrigo, Alba

AU - Heisler, Frank F

AU - Gutiérrez, Yolanda

AU - Lobo, Clara

AU - Kneussel, Matthias

AU - Esteban, José A

N1 - Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2021/8/3

Y1 - 2021/8/3

N2 - The synaptic removal of AMPA-type glutamate receptors (AMPARs) is a core mechanism for hippocampal long-term depression (LTD). In this study, we address the role of microtubule-dependent transport of AMPARs as a driver for vesicular trafficking and sorting during LTD. Here, we show that the kinesin-1 motor KIF5A/C is strictly required for LTD expression in CA3-to-CA1 hippocampal synapses. Specifically, we find that KIF5 is required for an efficient internalization of AMPARs after NMDA receptor activation. We show that the KIF5/AMPAR complex is assembled in an activity-dependent manner and associates with microsomal membranes upon LTD induction. This interaction is facilitated by the vesicular adaptor protrudin, which is also required for LTD expression. We propose that protrudin links KIF5-dependent transport to endosomal sorting, preventing AMPAR recycling to synapses after LTD induction. Therefore, this work identifies an activity-dependent molecular motor and the vesicular adaptor protein that executes AMPAR synaptic removal during LTD.

AB - The synaptic removal of AMPA-type glutamate receptors (AMPARs) is a core mechanism for hippocampal long-term depression (LTD). In this study, we address the role of microtubule-dependent transport of AMPARs as a driver for vesicular trafficking and sorting during LTD. Here, we show that the kinesin-1 motor KIF5A/C is strictly required for LTD expression in CA3-to-CA1 hippocampal synapses. Specifically, we find that KIF5 is required for an efficient internalization of AMPARs after NMDA receptor activation. We show that the KIF5/AMPAR complex is assembled in an activity-dependent manner and associates with microsomal membranes upon LTD induction. This interaction is facilitated by the vesicular adaptor protrudin, which is also required for LTD expression. We propose that protrudin links KIF5-dependent transport to endosomal sorting, preventing AMPAR recycling to synapses after LTD induction. Therefore, this work identifies an activity-dependent molecular motor and the vesicular adaptor protein that executes AMPAR synaptic removal during LTD.

U2 - 10.1016/j.celrep.2021.109499

DO - 10.1016/j.celrep.2021.109499

M3 - SCORING: Journal article

C2 - 34348158

VL - 36

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 5

M1 - 109499

ER -