A genome-wide survey of human short-term memory.
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A genome-wide survey of human short-term memory. / Papassotiropoulos, A; Henke, K; Stefanova, E; Aerni, A; Müller, A; Demougin, P; Vogler, C; Sigmund, J C; Gschwind, L; Huynh, K-D; Coluccia, D; Mondadori, C R; Hänggi, J; Buchmann, A; Kostic, V; Novakovic, I; Bussche van den, Hendrik; Kaduszkiewicz, Hanna; Weyerer, S; Bickel, H; Riedel-Heller, S; Pentzek, M; Wiese, B; Dichgans, M; Wagner, M; Jessen, F; Maier, W; de Quervain, D J-F.
in: MOL PSYCHIATR, Jahrgang 16, Nr. 2, 2, 2011, S. 184-192.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A genome-wide survey of human short-term memory.
AU - Papassotiropoulos, A
AU - Henke, K
AU - Stefanova, E
AU - Aerni, A
AU - Müller, A
AU - Demougin, P
AU - Vogler, C
AU - Sigmund, J C
AU - Gschwind, L
AU - Huynh, K-D
AU - Coluccia, D
AU - Mondadori, C R
AU - Hänggi, J
AU - Buchmann, A
AU - Kostic, V
AU - Novakovic, I
AU - Bussche van den, Hendrik
AU - Kaduszkiewicz, Hanna
AU - Weyerer, S
AU - Bickel, H
AU - Riedel-Heller, S
AU - Pentzek, M
AU - Wiese, B
AU - Dichgans, M
AU - Wagner, M
AU - Jessen, F
AU - Maier, W
AU - de Quervain, D J-F
PY - 2011
Y1 - 2011
N2 - Recent advances in the development of high-throughput genotyping platforms allow for the unbiased identification of genes and genomic sequences related to heritable traits. In this study, we analyzed human short-term memory, which refers to the ability to remember information over a brief period of time and which has been found disturbed in many neuropsychiatric conditions, including schizophrenia and depression. We performed a genome-wide survey at 909?622 polymorphic loci and report six genetic variations significantly associated with human short-term memory performance after genome-wide correction for multiple comparisons. A polymorphism within SCN1A (encoding the ? subunit of the type I voltage-gated sodium channel) was replicated in three independent populations of 1699 individuals. Functional magnetic resonance imaging during an n-back working memory task detected SCN1A allele-dependent activation differences in brain regions typically involved in working memory processes. These results suggest an important role for SCN1A in human short-term memory.
AB - Recent advances in the development of high-throughput genotyping platforms allow for the unbiased identification of genes and genomic sequences related to heritable traits. In this study, we analyzed human short-term memory, which refers to the ability to remember information over a brief period of time and which has been found disturbed in many neuropsychiatric conditions, including schizophrenia and depression. We performed a genome-wide survey at 909?622 polymorphic loci and report six genetic variations significantly associated with human short-term memory performance after genome-wide correction for multiple comparisons. A polymorphism within SCN1A (encoding the ? subunit of the type I voltage-gated sodium channel) was replicated in three independent populations of 1699 individuals. Functional magnetic resonance imaging during an n-back working memory task detected SCN1A allele-dependent activation differences in brain regions typically involved in working memory processes. These results suggest an important role for SCN1A in human short-term memory.
M3 - SCORING: Journal article
VL - 16
SP - 184
EP - 192
JO - MOL PSYCHIATR
JF - MOL PSYCHIATR
SN - 1359-4184
IS - 2
M1 - 2
ER -