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A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

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A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. / Middha, Pooja; Wang, Xiaoliang; Behrens, Sabine; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Ahearn, Thomas U; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Aronson, Kristan J; Auer, Paul L; Augustinsson, Annelie; Baert, Thaïs; Freeman, Laura E Beane; Becher, Heiko; Beckmann, Matthias W; Benitez, Javier; Bojesen, Stig E; Brauch, Hiltrud; Brenner, Hermann; Brooks-Wilson, Angela; Campa, Daniele; Canzian, Federico; Carracedo, Angel; Castelao, Jose E; Chanock, Stephen J; Chenevix-Trench, Georgia; Cordina-Duverger, Emilie; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Dossus, Laure; Dugué, Pierre-Antoine; Eliassen, A Heather; Eriksson, Mikael; Evans, D Gareth; Fasching, Peter A; Figueroa, Jonine D; Fletcher, Olivia; Flyger, Henrik; Gabrielson, Marike; Gago-Dominguez, Manuela; Giles, Graham G; González-Neira, Anna; Grassmann, Felix; Grundy, Anne; Guénel, Pascal; Haiman, Christopher A; Håkansson, Niclas; Hall, Per; Hamann, Ute; Hankinson, Susan E; Harkness, Elaine F; Holleczek, Bernd; Hoppe, Reiner; Hopper, John L; Houlston, Richard S; Howell, Anthony; Hunter, David J; Ingvar, Christian; Isaksson, Karolin; Jernström, Helena; John, Esther M; Jones, Michael E; Kaaks, Rudolf; Keeman, Renske; Kitahara, Cari M; Ko, Yon-Dschun; Koutros, Stella; Kurian, Allison W; Lacey, James V; Lambrechts, Diether; Larson, Nicole L; Larsson, Susanna; Le Marchand, Loic; Lejbkowicz, Flavio; Li, Shuai; Linet, Martha; Lissowska, Jolanta; Martinez, Maria Elena; Maurer, Tabea; Mulligan, Anna Marie; Mulot, Claire; Murphy, Rachel A; Newman, William G; Nielsen, Sune F; Nordestgaard, Børge G; Norman, Aaron; O'Brien, Katie M; Olson, Janet E; Patel, Alpa V; Prentice, Ross; Rees-Punia, Erika; Rennert, Gad; Rhenius, Valerie; Ruddy, Kathryn J; Sandler, Dale P; Scott, Christopher G; Shah, Mitul; Shu, Xiao-Ou; Smeets, Ann; Southey, Melissa C; Stone, Jennifer; Tamimi, Rulla M; Taylor, Jack A; Teras, Lauren R; Tomczyk, Katarzyna; Troester, Melissa A; Truong, Thérèse; Vachon, Celine M; Wang, Sophia S; Weinberg, Clarice R; Wildiers, Hans; Willett, Walter; Winham, Stacey J; Wolk, Alicja; Yang, Xiaohong R; Zamora, M Pilar; Zheng, Wei; Ziogas, Argyrios; Dunning, Alison M; Pharoah, Paul D P; García-Closas, Montserrat; Schmidt, Marjanka K; Kraft, Peter; Milne, Roger L; Lindström, Sara; Easton, Douglas F; Chang-Claude, Jenny; CTS Consortium; ABCTB Investigators; KConFab Investigators.

in: BREAST CANCER RES, Jahrgang 25, Nr. 1, 93, 09.08.2023.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Middha, P, Wang, X, Behrens, S, Bolla, MK, Wang, Q, Dennis, J, Michailidou, K, Ahearn, TU, Andrulis, IL, Anton-Culver, H, Arndt, V, Aronson, KJ, Auer, PL, Augustinsson, A, Baert, T, Freeman, LEB, Becher, H, Beckmann, MW, Benitez, J, Bojesen, SE, Brauch, H, Brenner, H, Brooks-Wilson, A, Campa, D, Canzian, F, Carracedo, A, Castelao, JE, Chanock, SJ, Chenevix-Trench, G, Cordina-Duverger, E, Couch, FJ, Cox, A, Cross, SS, Czene, K, Dossus, L, Dugué, P-A, Eliassen, AH, Eriksson, M, Evans, DG, Fasching, PA, Figueroa, JD, Fletcher, O, Flyger, H, Gabrielson, M, Gago-Dominguez, M, Giles, GG, González-Neira, A, Grassmann, F, Grundy, A, Guénel, P, Haiman, CA, Håkansson, N, Hall, P, Hamann, U, Hankinson, SE, Harkness, EF, Holleczek, B, Hoppe, R, Hopper, JL, Houlston, RS, Howell, A, Hunter, DJ, Ingvar, C, Isaksson, K, Jernström, H, John, EM, Jones, ME, Kaaks, R, Keeman, R, Kitahara, CM, Ko, Y-D, Koutros, S, Kurian, AW, Lacey, JV, Lambrechts, D, Larson, NL, Larsson, S, Le Marchand, L, Lejbkowicz, F, Li, S, Linet, M, Lissowska, J, Martinez, ME, Maurer, T, Mulligan, AM, Mulot, C, Murphy, RA, Newman, WG, Nielsen, SF, Nordestgaard, BG, Norman, A, O'Brien, KM, Olson, JE, Patel, AV, Prentice, R, Rees-Punia, E, Rennert, G, Rhenius, V, Ruddy, KJ, Sandler, DP, Scott, CG, Shah, M, Shu, X-O, Smeets, A, Southey, MC, Stone, J, Tamimi, RM, Taylor, JA, Teras, LR, Tomczyk, K, Troester, MA, Truong, T, Vachon, CM, Wang, SS, Weinberg, CR, Wildiers, H, Willett, W, Winham, SJ, Wolk, A, Yang, XR, Zamora, MP, Zheng, W, Ziogas, A, Dunning, AM, Pharoah, PDP, García-Closas, M, Schmidt, MK, Kraft, P, Milne, RL, Lindström, S, Easton, DF, Chang-Claude, J, CTS Consortium, ABCTB Investigators & KConFab Investigators 2023, 'A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry', BREAST CANCER RES, Jg. 25, Nr. 1, 93. https://doi.org/10.1186/s13058-023-01691-8

APA

Middha, P., Wang, X., Behrens, S., Bolla, M. K., Wang, Q., Dennis, J., Michailidou, K., Ahearn, T. U., Andrulis, I. L., Anton-Culver, H., Arndt, V., Aronson, K. J., Auer, P. L., Augustinsson, A., Baert, T., Freeman, L. E. B., Becher, H., Beckmann, M. W., Benitez, J., ... KConFab Investigators (2023). A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. BREAST CANCER RES, 25(1), [93]. https://doi.org/10.1186/s13058-023-01691-8

Vancouver

Middha P, Wang X, Behrens S, Bolla MK, Wang Q, Dennis J et al. A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. BREAST CANCER RES. 2023 Aug 9;25(1). 93. https://doi.org/10.1186/s13058-023-01691-8

Bibtex

@article{2ffc8e3629ca49cab967042db793a1ce,
title = "A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry",
abstract = "BACKGROUND: Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.METHODS: Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs.RESULTS: Assuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94).CONCLUSIONS: Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer.",
keywords = "Adult, Female, Humans, Gene-Environment Interaction, Genetic Predisposition to Disease, Breast Neoplasms/etiology, Bayes Theorem, Genome-Wide Association Study, Risk Factors, Polymorphism, Single Nucleotide, Case-Control Studies",
author = "Pooja Middha and Xiaoliang Wang and Sabine Behrens and Bolla, {Manjeet K} and Qin Wang and Joe Dennis and Kyriaki Michailidou and Ahearn, {Thomas U} and Andrulis, {Irene L} and Hoda Anton-Culver and Volker Arndt and Aronson, {Kristan J} and Auer, {Paul L} and Annelie Augustinsson and Tha{\"i}s Baert and Freeman, {Laura E Beane} and Heiko Becher and Beckmann, {Matthias W} and Javier Benitez and Bojesen, {Stig E} and Hiltrud Brauch and Hermann Brenner and Angela Brooks-Wilson and Daniele Campa and Federico Canzian and Angel Carracedo and Castelao, {Jose E} and Chanock, {Stephen J} and Georgia Chenevix-Trench and Emilie Cordina-Duverger and Couch, {Fergus J} and Angela Cox and Cross, {Simon S} and Kamila Czene and Laure Dossus and Pierre-Antoine Dugu{\'e} and Eliassen, {A Heather} and Mikael Eriksson and Evans, {D Gareth} and Fasching, {Peter A} and Figueroa, {Jonine D} and Olivia Fletcher and Henrik Flyger and Marike Gabrielson and Manuela Gago-Dominguez and Giles, {Graham G} and Anna Gonz{\'a}lez-Neira and Felix Grassmann and Anne Grundy and Pascal Gu{\'e}nel and Haiman, {Christopher A} and Niclas H{\aa}kansson and Per Hall and Ute Hamann and Hankinson, {Susan E} and Harkness, {Elaine F} and Bernd Holleczek and Reiner Hoppe and Hopper, {John L} and Houlston, {Richard S} and Anthony Howell and Hunter, {David J} and Christian Ingvar and Karolin Isaksson and Helena Jernstr{\"o}m and John, {Esther M} and Jones, {Michael E} and Rudolf Kaaks and Renske Keeman and Kitahara, {Cari M} and Yon-Dschun Ko and Stella Koutros and Kurian, {Allison W} and Lacey, {James V} and Diether Lambrechts and Larson, {Nicole L} and Susanna Larsson and {Le Marchand}, Loic and Flavio Lejbkowicz and Shuai Li and Martha Linet and Jolanta Lissowska and Martinez, {Maria Elena} and Tabea Maurer and Mulligan, {Anna Marie} and Claire Mulot and Murphy, {Rachel A} and Newman, {William G} and Nielsen, {Sune F} and Nordestgaard, {B{\o}rge G} and Aaron Norman and O'Brien, {Katie M} and Olson, {Janet E} and Patel, {Alpa V} and Ross Prentice and Erika Rees-Punia and Gad Rennert and Valerie Rhenius and Ruddy, {Kathryn J} and Sandler, {Dale P} and Scott, {Christopher G} and Mitul Shah and Xiao-Ou Shu and Ann Smeets and Southey, {Melissa C} and Jennifer Stone and Tamimi, {Rulla M} and Taylor, {Jack A} and Teras, {Lauren R} and Katarzyna Tomczyk and Troester, {Melissa A} and Th{\'e}r{\`e}se Truong and Vachon, {Celine M} and Wang, {Sophia S} and Weinberg, {Clarice R} and Hans Wildiers and Walter Willett and Winham, {Stacey J} and Alicja Wolk and Yang, {Xiaohong R} and Zamora, {M Pilar} and Wei Zheng and Argyrios Ziogas and Dunning, {Alison M} and Pharoah, {Paul D P} and Montserrat Garc{\'i}a-Closas and Schmidt, {Marjanka K} and Peter Kraft and Milne, {Roger L} and Sara Lindstr{\"o}m and Easton, {Douglas F} and Jenny Chang-Claude and {CTS Consortium} and {ABCTB Investigators} and {KConFab Investigators}",
note = "{\textcopyright} 2023. BioMed Central Ltd., part of Springer Nature.",
year = "2023",
month = aug,
day = "9",
doi = "10.1186/s13058-023-01691-8",
language = "English",
volume = "25",
journal = "BREAST CANCER RES",
issn = "1465-5411",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

AU - Middha, Pooja

AU - Wang, Xiaoliang

AU - Behrens, Sabine

AU - Bolla, Manjeet K

AU - Wang, Qin

AU - Dennis, Joe

AU - Michailidou, Kyriaki

AU - Ahearn, Thomas U

AU - Andrulis, Irene L

AU - Anton-Culver, Hoda

AU - Arndt, Volker

AU - Aronson, Kristan J

AU - Auer, Paul L

AU - Augustinsson, Annelie

AU - Baert, Thaïs

AU - Freeman, Laura E Beane

AU - Becher, Heiko

AU - Beckmann, Matthias W

AU - Benitez, Javier

AU - Bojesen, Stig E

AU - Brauch, Hiltrud

AU - Brenner, Hermann

AU - Brooks-Wilson, Angela

AU - Campa, Daniele

AU - Canzian, Federico

AU - Carracedo, Angel

AU - Castelao, Jose E

AU - Chanock, Stephen J

AU - Chenevix-Trench, Georgia

AU - Cordina-Duverger, Emilie

AU - Couch, Fergus J

AU - Cox, Angela

AU - Cross, Simon S

AU - Czene, Kamila

AU - Dossus, Laure

AU - Dugué, Pierre-Antoine

AU - Eliassen, A Heather

AU - Eriksson, Mikael

AU - Evans, D Gareth

AU - Fasching, Peter A

AU - Figueroa, Jonine D

AU - Fletcher, Olivia

AU - Flyger, Henrik

AU - Gabrielson, Marike

AU - Gago-Dominguez, Manuela

AU - Giles, Graham G

AU - González-Neira, Anna

AU - Grassmann, Felix

AU - Grundy, Anne

AU - Guénel, Pascal

AU - Haiman, Christopher A

AU - Håkansson, Niclas

AU - Hall, Per

AU - Hamann, Ute

AU - Hankinson, Susan E

AU - Harkness, Elaine F

AU - Holleczek, Bernd

AU - Hoppe, Reiner

AU - Hopper, John L

AU - Houlston, Richard S

AU - Howell, Anthony

AU - Hunter, David J

AU - Ingvar, Christian

AU - Isaksson, Karolin

AU - Jernström, Helena

AU - John, Esther M

AU - Jones, Michael E

AU - Kaaks, Rudolf

AU - Keeman, Renske

AU - Kitahara, Cari M

AU - Ko, Yon-Dschun

AU - Koutros, Stella

AU - Kurian, Allison W

AU - Lacey, James V

AU - Lambrechts, Diether

AU - Larson, Nicole L

AU - Larsson, Susanna

AU - Le Marchand, Loic

AU - Lejbkowicz, Flavio

AU - Li, Shuai

AU - Linet, Martha

AU - Lissowska, Jolanta

AU - Martinez, Maria Elena

AU - Maurer, Tabea

AU - Mulligan, Anna Marie

AU - Mulot, Claire

AU - Murphy, Rachel A

AU - Newman, William G

AU - Nielsen, Sune F

AU - Nordestgaard, Børge G

AU - Norman, Aaron

AU - O'Brien, Katie M

AU - Olson, Janet E

AU - Patel, Alpa V

AU - Prentice, Ross

AU - Rees-Punia, Erika

AU - Rennert, Gad

AU - Rhenius, Valerie

AU - Ruddy, Kathryn J

AU - Sandler, Dale P

AU - Scott, Christopher G

AU - Shah, Mitul

AU - Shu, Xiao-Ou

AU - Smeets, Ann

AU - Southey, Melissa C

AU - Stone, Jennifer

AU - Tamimi, Rulla M

AU - Taylor, Jack A

AU - Teras, Lauren R

AU - Tomczyk, Katarzyna

AU - Troester, Melissa A

AU - Truong, Thérèse

AU - Vachon, Celine M

AU - Wang, Sophia S

AU - Weinberg, Clarice R

AU - Wildiers, Hans

AU - Willett, Walter

AU - Winham, Stacey J

AU - Wolk, Alicja

AU - Yang, Xiaohong R

AU - Zamora, M Pilar

AU - Zheng, Wei

AU - Ziogas, Argyrios

AU - Dunning, Alison M

AU - Pharoah, Paul D P

AU - García-Closas, Montserrat

AU - Schmidt, Marjanka K

AU - Kraft, Peter

AU - Milne, Roger L

AU - Lindström, Sara

AU - Easton, Douglas F

AU - Chang-Claude, Jenny

AU - CTS Consortium

AU - ABCTB Investigators

AU - KConFab Investigators

N1 - © 2023. BioMed Central Ltd., part of Springer Nature.

PY - 2023/8/9

Y1 - 2023/8/9

N2 - BACKGROUND: Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.METHODS: Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs.RESULTS: Assuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94).CONCLUSIONS: Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer.

AB - BACKGROUND: Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.METHODS: Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs.RESULTS: Assuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94).CONCLUSIONS: Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer.

KW - Adult

KW - Female

KW - Humans

KW - Gene-Environment Interaction

KW - Genetic Predisposition to Disease

KW - Breast Neoplasms/etiology

KW - Bayes Theorem

KW - Genome-Wide Association Study

KW - Risk Factors

KW - Polymorphism, Single Nucleotide

KW - Case-Control Studies

U2 - 10.1186/s13058-023-01691-8

DO - 10.1186/s13058-023-01691-8

M3 - SCORING: Journal article

C2 - 37559094

VL - 25

JO - BREAST CANCER RES

JF - BREAST CANCER RES

SN - 1465-5411

IS - 1

M1 - 93

ER -