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A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs

Standard

A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs. / Bauer, Christiane K.; Schäfer, R; Schiemann, D; Reid, G; Hanganu, I; Schwarz, J R.

in: MOL CELL ENDOCRINOL, Jahrgang 148, Nr. 1-2, 1-2, 1999, S. 37-45.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bauer, CK, Schäfer, R, Schiemann, D, Reid, G, Hanganu, I & Schwarz, JR 1999, 'A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs', MOL CELL ENDOCRINOL, Jg. 148, Nr. 1-2, 1-2, S. 37-45. https://doi.org/10.1016/s0303-7207(98)00241-x

APA

Bauer, C. K., Schäfer, R., Schiemann, D., Reid, G., Hanganu, I., & Schwarz, J. R. (1999). A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs. MOL CELL ENDOCRINOL, 148(1-2), 37-45. [1-2]. https://doi.org/10.1016/s0303-7207(98)00241-x

Vancouver

Bauer CK, Schäfer R, Schiemann D, Reid G, Hanganu I, Schwarz JR. A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs. MOL CELL ENDOCRINOL. 1999;148(1-2):37-45. 1-2. https://doi.org/10.1016/s0303-7207(98)00241-x

Bibtex

@article{db536b578033436784418a817d0ca7c9,
title = "A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs",
abstract = "The functional role of the inward-rectifying erg-like K+ current in rat lactotrophs was studied by the use of a selective blocker, the class III antiarrhythmic agent E-4031. The erg-like current was measured as drug-sensitive current in physiological K+ gradient. In the range of the normal resting membrane potential of rat lactotrophs (around -45 mV) the erg-like current constituted a steady outward current. A selective block of this current by E-4031 resulted in a moderate (5 mV) depolarization of the membrane potential in 64% of the lactotroph cells. Measurements of basal prolactin secretion with the reverse hemolytic plaque assay showed that the number of prolactin secreting cells and the amount of prolactin secreted from single lactotrophs was significantly increased in the presence of E-4031. The data show that the contribution of the erg-like K+ current to the maintenance of the resting membrane potential is functionally important for the regulation of prolactin secretion.",
author = "Bauer, {Christiane K.} and R Sch{\"a}fer and D Schiemann and G Reid and I Hanganu and Schwarz, {J R}",
year = "1999",
doi = "10.1016/s0303-7207(98)00241-x",
language = "English",
volume = "148",
pages = "37--45",
journal = "MOL CELL ENDOCRINOL",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

RIS

TY - JOUR

T1 - A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs

AU - Bauer, Christiane K.

AU - Schäfer, R

AU - Schiemann, D

AU - Reid, G

AU - Hanganu, I

AU - Schwarz, J R

PY - 1999

Y1 - 1999

N2 - The functional role of the inward-rectifying erg-like K+ current in rat lactotrophs was studied by the use of a selective blocker, the class III antiarrhythmic agent E-4031. The erg-like current was measured as drug-sensitive current in physiological K+ gradient. In the range of the normal resting membrane potential of rat lactotrophs (around -45 mV) the erg-like current constituted a steady outward current. A selective block of this current by E-4031 resulted in a moderate (5 mV) depolarization of the membrane potential in 64% of the lactotroph cells. Measurements of basal prolactin secretion with the reverse hemolytic plaque assay showed that the number of prolactin secreting cells and the amount of prolactin secreted from single lactotrophs was significantly increased in the presence of E-4031. The data show that the contribution of the erg-like K+ current to the maintenance of the resting membrane potential is functionally important for the regulation of prolactin secretion.

AB - The functional role of the inward-rectifying erg-like K+ current in rat lactotrophs was studied by the use of a selective blocker, the class III antiarrhythmic agent E-4031. The erg-like current was measured as drug-sensitive current in physiological K+ gradient. In the range of the normal resting membrane potential of rat lactotrophs (around -45 mV) the erg-like current constituted a steady outward current. A selective block of this current by E-4031 resulted in a moderate (5 mV) depolarization of the membrane potential in 64% of the lactotroph cells. Measurements of basal prolactin secretion with the reverse hemolytic plaque assay showed that the number of prolactin secreting cells and the amount of prolactin secreted from single lactotrophs was significantly increased in the presence of E-4031. The data show that the contribution of the erg-like K+ current to the maintenance of the resting membrane potential is functionally important for the regulation of prolactin secretion.

U2 - 10.1016/s0303-7207(98)00241-x

DO - 10.1016/s0303-7207(98)00241-x

M3 - SCORING: Journal article

VL - 148

SP - 37

EP - 45

JO - MOL CELL ENDOCRINOL

JF - MOL CELL ENDOCRINOL

SN - 0303-7207

IS - 1-2

M1 - 1-2

ER -