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A function for the calponin family member NP25 in neurite outgrowth.

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A function for the calponin family member NP25 in neurite outgrowth. / Pape, Manuela; Doxakis, Epaminondas; Reiff, Tobias; Duong, Chi Vinh; Davies, Alun; Geissen, Markus; Rohrer, Hermann.

in: DEV BIOL, Jahrgang 321, Nr. 2, 2, 2008, S. 434-443.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Pape, M, Doxakis, E, Reiff, T, Duong, CV, Davies, A, Geissen, M & Rohrer, H 2008, 'A function for the calponin family member NP25 in neurite outgrowth.', DEV BIOL, Jg. 321, Nr. 2, 2, S. 434-443. <http://www.ncbi.nlm.nih.gov/pubmed/18652818?dopt=Citation>

APA

Pape, M., Doxakis, E., Reiff, T., Duong, C. V., Davies, A., Geissen, M., & Rohrer, H. (2008). A function for the calponin family member NP25 in neurite outgrowth. DEV BIOL, 321(2), 434-443. [2]. http://www.ncbi.nlm.nih.gov/pubmed/18652818?dopt=Citation

Vancouver

Pape M, Doxakis E, Reiff T, Duong CV, Davies A, Geissen M et al. A function for the calponin family member NP25 in neurite outgrowth. DEV BIOL. 2008;321(2):434-443. 2.

Bibtex

@article{064467d83413437bb699bfe9e1fa51e6,
title = "A function for the calponin family member NP25 in neurite outgrowth.",
abstract = "The neuronal protein 25 (NP25), a member of the calponin (CaP) protein family, has previously been identified as neuron-specific protein in the adult rat brain. Here, we show an early onset of NP25 expression in the chick embryo neural tube. NP25 represents, together with NeuroM, one of the earliest markers for postmitotic neurons. To elucidate its function in the developing nervous system, NP25 was overexpressed in E5 and E9 sensory neurons, E7 sympathetic neurons and PC12 cells that show different endogenous NP25 expression levels. Whereas E5 and E9 sensory neurons and PC12 cells, which express low endogenous levels of NP25, responded by enhanced neurite outgrowth, a reduction of neurite length was observed in sympathetic neurons, which already express high endogenous levels of NP25. Knockdown of NP25 in sensory neurons using NP25 siRNA resulted in shorter neurites, whereas reduction of NP25 expression in sympathetic neurons led to increased neurite length. These results suggest a dynamic function for NP25 in the regulation of neurite growth, with an optimal level of NP25 required for maximal growth.",
author = "Manuela Pape and Epaminondas Doxakis and Tobias Reiff and Duong, {Chi Vinh} and Alun Davies and Markus Geissen and Hermann Rohrer",
year = "2008",
language = "English",
volume = "321",
pages = "434--443",
journal = "DEV BIOL",
issn = "0012-1606",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - A function for the calponin family member NP25 in neurite outgrowth.

AU - Pape, Manuela

AU - Doxakis, Epaminondas

AU - Reiff, Tobias

AU - Duong, Chi Vinh

AU - Davies, Alun

AU - Geissen, Markus

AU - Rohrer, Hermann

PY - 2008

Y1 - 2008

N2 - The neuronal protein 25 (NP25), a member of the calponin (CaP) protein family, has previously been identified as neuron-specific protein in the adult rat brain. Here, we show an early onset of NP25 expression in the chick embryo neural tube. NP25 represents, together with NeuroM, one of the earliest markers for postmitotic neurons. To elucidate its function in the developing nervous system, NP25 was overexpressed in E5 and E9 sensory neurons, E7 sympathetic neurons and PC12 cells that show different endogenous NP25 expression levels. Whereas E5 and E9 sensory neurons and PC12 cells, which express low endogenous levels of NP25, responded by enhanced neurite outgrowth, a reduction of neurite length was observed in sympathetic neurons, which already express high endogenous levels of NP25. Knockdown of NP25 in sensory neurons using NP25 siRNA resulted in shorter neurites, whereas reduction of NP25 expression in sympathetic neurons led to increased neurite length. These results suggest a dynamic function for NP25 in the regulation of neurite growth, with an optimal level of NP25 required for maximal growth.

AB - The neuronal protein 25 (NP25), a member of the calponin (CaP) protein family, has previously been identified as neuron-specific protein in the adult rat brain. Here, we show an early onset of NP25 expression in the chick embryo neural tube. NP25 represents, together with NeuroM, one of the earliest markers for postmitotic neurons. To elucidate its function in the developing nervous system, NP25 was overexpressed in E5 and E9 sensory neurons, E7 sympathetic neurons and PC12 cells that show different endogenous NP25 expression levels. Whereas E5 and E9 sensory neurons and PC12 cells, which express low endogenous levels of NP25, responded by enhanced neurite outgrowth, a reduction of neurite length was observed in sympathetic neurons, which already express high endogenous levels of NP25. Knockdown of NP25 in sensory neurons using NP25 siRNA resulted in shorter neurites, whereas reduction of NP25 expression in sympathetic neurons led to increased neurite length. These results suggest a dynamic function for NP25 in the regulation of neurite growth, with an optimal level of NP25 required for maximal growth.

M3 - SCORING: Journal article

VL - 321

SP - 434

EP - 443

JO - DEV BIOL

JF - DEV BIOL

SN - 0012-1606

IS - 2

M1 - 2

ER -