A formula to calculate the standard liver volume in children and its application in pediatric liver transplantation
Standard
A formula to calculate the standard liver volume in children and its application in pediatric liver transplantation. / Herden, Uta; Wischhusen, Friedel; Heinemann, Axel; Ganschow, Rainer; Grabhorn, Enke; Vettorazzi, Eik; Nashan, Bjoern; Fischer, Lutz.
in: TRANSPL INT, Jahrgang 26, Nr. 12, 01.12.2013, S. 1217-24.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A formula to calculate the standard liver volume in children and its application in pediatric liver transplantation
AU - Herden, Uta
AU - Wischhusen, Friedel
AU - Heinemann, Axel
AU - Ganschow, Rainer
AU - Grabhorn, Enke
AU - Vettorazzi, Eik
AU - Nashan, Bjoern
AU - Fischer, Lutz
N1 - © 2013 Steunstichting ESOT. Published by John Wiley & Sons Ltd.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Due to a lack of available size-matched liver grafts from children, most pediatric recipients are transplanted with technical variant grafts from adult donors. Size requirements for these grafts are not well defined, and consequences of mismatched graft sizes in pediatric liver transplantation are not known. Existing formulas for calculation of a standard liver volume are mostly derived from adults disregarding the age-related percentual liver weight changes in children. In this study, we aimed to establish a formula for general use in children to calculate the standard liver volume. In a second step, the formula was applied in pediatric patients undergoing liver transplantation at our institution between 2000 and 2010 (n = 377). Analysis of a large number (n = 388) of autopsy data from children by regression analysis revealed a best fit for two formulas: "Formula 1," children 0 to ≤1 year (n = 246): standard liver volume [ml] = -143.062973 +4.274603051 * body length [cm] + 14.78817631 * body weight [kg]; "Formula 2," children >1 to <16 years (n = 142): standard liver volume [ml] = -20.2472281 + 3.339056437 * body length [cm] + 13.11312561 * body weight [kg]. In comparison with children receiving size-matched organs, we found an elevated risk of liver graft failure in children transplanted with a small-for-size graft, whereas large-for-size organs seem to have no negative impact.
AB - Due to a lack of available size-matched liver grafts from children, most pediatric recipients are transplanted with technical variant grafts from adult donors. Size requirements for these grafts are not well defined, and consequences of mismatched graft sizes in pediatric liver transplantation are not known. Existing formulas for calculation of a standard liver volume are mostly derived from adults disregarding the age-related percentual liver weight changes in children. In this study, we aimed to establish a formula for general use in children to calculate the standard liver volume. In a second step, the formula was applied in pediatric patients undergoing liver transplantation at our institution between 2000 and 2010 (n = 377). Analysis of a large number (n = 388) of autopsy data from children by regression analysis revealed a best fit for two formulas: "Formula 1," children 0 to ≤1 year (n = 246): standard liver volume [ml] = -143.062973 +4.274603051 * body length [cm] + 14.78817631 * body weight [kg]; "Formula 2," children >1 to <16 years (n = 142): standard liver volume [ml] = -20.2472281 + 3.339056437 * body length [cm] + 13.11312561 * body weight [kg]. In comparison with children receiving size-matched organs, we found an elevated risk of liver graft failure in children transplanted with a small-for-size graft, whereas large-for-size organs seem to have no negative impact.
U2 - 10.1111/tri.12198
DO - 10.1111/tri.12198
M3 - SCORING: Journal article
C2 - 24118382
VL - 26
SP - 1217
EP - 1224
JO - TRANSPL INT
JF - TRANSPL INT
SN - 0934-0874
IS - 12
ER -