A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions
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A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions. / Kira, Shinichiro; Safaai, Houman; Morcos, Ari S; Panzeri, Stefano; Harvey, Christopher D.
in: NAT COMMUN, Jahrgang 14, Nr. 1, 14.04.2023, S. 2121.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions
AU - Kira, Shinichiro
AU - Safaai, Houman
AU - Morcos, Ari S
AU - Panzeri, Stefano
AU - Harvey, Christopher D
N1 - © 2023. The Author(s).
PY - 2023/4/14
Y1 - 2023/4/14
N2 - Decision-making requires flexibility to rapidly switch one's actions in response to sensory stimuli depending on information stored in memory. We identified cortical areas and neural activity patterns underlying this flexibility during virtual navigation, where mice switched navigation toward or away from a visual cue depending on its match to a remembered cue. Optogenetics screening identified V1, posterior parietal cortex (PPC), and retrosplenial cortex (RSC) as necessary for accurate decisions. Calcium imaging revealed neurons that can mediate rapid navigation switches by encoding a mixture of a current and remembered visual cue. These mixed selectivity neurons emerged through task learning and predicted the mouse's choices by forming efficient population codes before correct, but not incorrect, choices. They were distributed across posterior cortex, even V1, and were densest in RSC and sparsest in PPC. We propose flexibility in navigation decisions arises from neurons that mix visual and memory information within a visual-parietal-retrosplenial network.
AB - Decision-making requires flexibility to rapidly switch one's actions in response to sensory stimuli depending on information stored in memory. We identified cortical areas and neural activity patterns underlying this flexibility during virtual navigation, where mice switched navigation toward or away from a visual cue depending on its match to a remembered cue. Optogenetics screening identified V1, posterior parietal cortex (PPC), and retrosplenial cortex (RSC) as necessary for accurate decisions. Calcium imaging revealed neurons that can mediate rapid navigation switches by encoding a mixture of a current and remembered visual cue. These mixed selectivity neurons emerged through task learning and predicted the mouse's choices by forming efficient population codes before correct, but not incorrect, choices. They were distributed across posterior cortex, even V1, and were densest in RSC and sparsest in PPC. We propose flexibility in navigation decisions arises from neurons that mix visual and memory information within a visual-parietal-retrosplenial network.
KW - Mice
KW - Animals
KW - Parietal Lobe/physiology
KW - Learning
KW - Neurons/physiology
KW - Gyrus Cinguli
U2 - 10.1038/s41467-023-37804-2
DO - 10.1038/s41467-023-37804-2
M3 - SCORING: Journal article
C2 - 37055431
VL - 14
SP - 2121
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
IS - 1
ER -