A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies.

T Niehues; P Kapaun; D O Harms; S Burdach; C Kramm; D Körholz; Gritta Janka-Schaub; U Göbel

A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies.

Standard

A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies. / Niehues, T; Kapaun, P; Harms, D O; Burdach, S; Kramm, C; Körholz, D; Janka-Schaub, Gritta; Göbel, U.

in: LEUKEMIA, Jahrgang 13, Nr. 4, 4, 1999, S. 614-617.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Niehues, T, Kapaun, P, Harms, DO, Burdach, S, Kramm, C, Körholz, D, Janka-Schaub, G & Göbel, U 1999, 'A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies.', LEUKEMIA, Jg. 13, Nr. 4, 4, S. 614-617. <http://www.ncbi.nlm.nih.gov/pubmed/10214870?dopt=Citation>

APA

Niehues, T., Kapaun, P., Harms, D. O., Burdach, S., Kramm, C., Körholz, D., Janka-Schaub, G., & Göbel, U. (1999). A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies. LEUKEMIA, 13(4), 614-617. [4]. http://www.ncbi.nlm.nih.gov/pubmed/10214870?dopt=Citation

Vancouver

Niehues T, Kapaun P, Harms DO, Burdach S, Kramm C, Körholz D et al. A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies. LEUKEMIA. 1999;13(4):614-617. 4.

Bibtex

@article{4540122657ee44568cb6fe8c75ef0370,

title = "A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies.",

abstract = "During T cell selection in the thymic cortex more than 90% of the thymocytes are eliminated by apoptosis. Based on this biology, we propose to define blasts of T cell acute lymphoblastic leukemia (ALL) with the phenotype of cortical thymocytes (CD1+ and/or CD4+ 8+) as selection-related (SR) and all other T-ALL immunophenotypes as non-selection-related (NSR). The COALL cooperative treatment studies for childhood ALL offer a tool to study the outcome in T-ALL subgroups as children with T-ALL are allocated uniformly to the high risk arm of the protocol. In the COALL-85, -89 and -92 protocols, 39/83 cases presented as SR and 44/83 cases as NSR. Five-year event-free survival of SR phenotype is significantly better compared to the NSR group (0.87 +/- 0.06 vs 0.66 +/- 0.07, log rank test, P = 0.01). T-ALL with SR phenotype is a distinct subgroup of leukemia with excellent prognosis under a high risk treatment protocol.",

author = "T Niehues and P Kapaun and Harms, {D O} and S Burdach and C Kramm and D K{\"o}rholz and Gritta Janka-Schaub and U G{\"o}bel",

year = "1999",

language = "Deutsch",

volume = "13",

pages = "614--617",

journal = "LEUKEMIA",

issn = "0887-6924",

publisher = "NATURE PUBLISHING GROUP",

number = "4",

}

RIS

TY - JOUR

T1 - A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies.

AU - Niehues, T

AU - Kapaun, P

AU - Harms, D O

AU - Burdach, S

AU - Kramm, C

AU - Körholz, D

AU - Janka-Schaub, Gritta

AU - Göbel, U

PY - 1999

Y1 - 1999

N2 - During T cell selection in the thymic cortex more than 90% of the thymocytes are eliminated by apoptosis. Based on this biology, we propose to define blasts of T cell acute lymphoblastic leukemia (ALL) with the phenotype of cortical thymocytes (CD1+ and/or CD4+ 8+) as selection-related (SR) and all other T-ALL immunophenotypes as non-selection-related (NSR). The COALL cooperative treatment studies for childhood ALL offer a tool to study the outcome in T-ALL subgroups as children with T-ALL are allocated uniformly to the high risk arm of the protocol. In the COALL-85, -89 and -92 protocols, 39/83 cases presented as SR and 44/83 cases as NSR. Five-year event-free survival of SR phenotype is significantly better compared to the NSR group (0.87 +/- 0.06 vs 0.66 +/- 0.07, log rank test, P = 0.01). T-ALL with SR phenotype is a distinct subgroup of leukemia with excellent prognosis under a high risk treatment protocol.

AB - During T cell selection in the thymic cortex more than 90% of the thymocytes are eliminated by apoptosis. Based on this biology, we propose to define blasts of T cell acute lymphoblastic leukemia (ALL) with the phenotype of cortical thymocytes (CD1+ and/or CD4+ 8+) as selection-related (SR) and all other T-ALL immunophenotypes as non-selection-related (NSR). The COALL cooperative treatment studies for childhood ALL offer a tool to study the outcome in T-ALL subgroups as children with T-ALL are allocated uniformly to the high risk arm of the protocol. In the COALL-85, -89 and -92 protocols, 39/83 cases presented as SR and 44/83 cases as NSR. Five-year event-free survival of SR phenotype is significantly better compared to the NSR group (0.87 +/- 0.06 vs 0.66 +/- 0.07, log rank test, P = 0.01). T-ALL with SR phenotype is a distinct subgroup of leukemia with excellent prognosis under a high risk treatment protocol.

M3 - SCORING: Zeitschriftenaufsatz

VL - 13

SP - 614

EP - 617

JO - LEUKEMIA

JF - LEUKEMIA

SN - 0887-6924

IS - 4

M1 - 4

ER -