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3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma

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3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma. / Schneider, Tanja; Chapiro, J; Lin, M; Geschwind, J F; Kleinberg, L; Rigamonti, D; Jusué-Torres, I; Marciscano, A E; Yousem, D M.

in: EUR RADIOL, Jahrgang 26, Nr. 3, 01.03.2016, S. 849-57.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schneider, T, Chapiro, J, Lin, M, Geschwind, JF, Kleinberg, L, Rigamonti, D, Jusué-Torres, I, Marciscano, AE & Yousem, DM 2016, '3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma', EUR RADIOL, Jg. 26, Nr. 3, S. 849-57. https://doi.org/10.1007/s00330-015-3895-9

APA

Schneider, T., Chapiro, J., Lin, M., Geschwind, J. F., Kleinberg, L., Rigamonti, D., Jusué-Torres, I., Marciscano, A. E., & Yousem, D. M. (2016). 3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma. EUR RADIOL, 26(3), 849-57. https://doi.org/10.1007/s00330-015-3895-9

Vancouver

Schneider T, Chapiro J, Lin M, Geschwind JF, Kleinberg L, Rigamonti D et al. 3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma. EUR RADIOL. 2016 Mär 1;26(3):849-57. https://doi.org/10.1007/s00330-015-3895-9

Bibtex

@article{5ff9522fc0e647ea97a536f5c6e1f267,
title = "3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma",
abstract = "OBJECTIVES: To determine clinical outcome of patients with vestibular schwannoma (VS) after treatment with fractionated stereotactic radiotherapy (FSRT) and single-session stereotactic radiosurgery (SRS) by using 3D quantitative response assessment on MRI.MATERIALS: This retrospective analysis included 162 patients who underwent radiation therapy for sporadic VS. Measurements on T1-weighted contrast-enhanced MRI (in 2-year post-therapy intervals: 0-2, 2-4, 4-6, 6-8, 8-10, 10-12 years) were taken for total tumour volume (TTV) and enhancing tumour volume (ETV) based on a semi-automated technique. Patients were considered non-responders (NRs) if they required subsequent microsurgical resection or developed radiological progression and tumour-related symptoms.RESULTS: Median follow-up was 4.1 years (range: 0.4-12.0). TTV and ETV decreased for both the FSRT and SRS groups. However, only the FSRT group achieved significant tumour shrinkage (p < 0.015 for TTV, p < 0.005 for ETV over time). The 11 NRs showed proportionally greater TTV (median TTV pre-treatment: 0.61 cm(3), 8-10 years after: 1.77 cm(3)) and ETV despite radiation therapy compared to responders (median TTV pre-treatment: 1.06 cm(3); 10-12 years after: 0.81 cm(3); p = 0.001).CONCLUSION: 3D quantification of VS showed a significant decrease in TTV and ETV on FSRT-treated patients only. NR had significantly greater TTV and ETV over time.KEY POINTS: • Only FSRT not GK-treated patients showed significant tumour shrinkage over time. • Clinical non-responders showed significantly less tumour shrinkage when compared to responders. • 3D volumetric assessment of vestibular schwannoma shows advantages over unidimensional techniques.",
author = "Tanja Schneider and J Chapiro and M Lin and Geschwind, {J F} and L Kleinberg and D Rigamonti and I Jusu{\'e}-Torres and Marciscano, {A E} and Yousem, {D M}",
year = "2016",
month = mar,
day = "1",
doi = "10.1007/s00330-015-3895-9",
language = "English",
volume = "26",
pages = "849--57",
journal = "EUR RADIOL",
issn = "0938-7994",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - 3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma

AU - Schneider, Tanja

AU - Chapiro, J

AU - Lin, M

AU - Geschwind, J F

AU - Kleinberg, L

AU - Rigamonti, D

AU - Jusué-Torres, I

AU - Marciscano, A E

AU - Yousem, D M

PY - 2016/3/1

Y1 - 2016/3/1

N2 - OBJECTIVES: To determine clinical outcome of patients with vestibular schwannoma (VS) after treatment with fractionated stereotactic radiotherapy (FSRT) and single-session stereotactic radiosurgery (SRS) by using 3D quantitative response assessment on MRI.MATERIALS: This retrospective analysis included 162 patients who underwent radiation therapy for sporadic VS. Measurements on T1-weighted contrast-enhanced MRI (in 2-year post-therapy intervals: 0-2, 2-4, 4-6, 6-8, 8-10, 10-12 years) were taken for total tumour volume (TTV) and enhancing tumour volume (ETV) based on a semi-automated technique. Patients were considered non-responders (NRs) if they required subsequent microsurgical resection or developed radiological progression and tumour-related symptoms.RESULTS: Median follow-up was 4.1 years (range: 0.4-12.0). TTV and ETV decreased for both the FSRT and SRS groups. However, only the FSRT group achieved significant tumour shrinkage (p < 0.015 for TTV, p < 0.005 for ETV over time). The 11 NRs showed proportionally greater TTV (median TTV pre-treatment: 0.61 cm(3), 8-10 years after: 1.77 cm(3)) and ETV despite radiation therapy compared to responders (median TTV pre-treatment: 1.06 cm(3); 10-12 years after: 0.81 cm(3); p = 0.001).CONCLUSION: 3D quantification of VS showed a significant decrease in TTV and ETV on FSRT-treated patients only. NR had significantly greater TTV and ETV over time.KEY POINTS: • Only FSRT not GK-treated patients showed significant tumour shrinkage over time. • Clinical non-responders showed significantly less tumour shrinkage when compared to responders. • 3D volumetric assessment of vestibular schwannoma shows advantages over unidimensional techniques.

AB - OBJECTIVES: To determine clinical outcome of patients with vestibular schwannoma (VS) after treatment with fractionated stereotactic radiotherapy (FSRT) and single-session stereotactic radiosurgery (SRS) by using 3D quantitative response assessment on MRI.MATERIALS: This retrospective analysis included 162 patients who underwent radiation therapy for sporadic VS. Measurements on T1-weighted contrast-enhanced MRI (in 2-year post-therapy intervals: 0-2, 2-4, 4-6, 6-8, 8-10, 10-12 years) were taken for total tumour volume (TTV) and enhancing tumour volume (ETV) based on a semi-automated technique. Patients were considered non-responders (NRs) if they required subsequent microsurgical resection or developed radiological progression and tumour-related symptoms.RESULTS: Median follow-up was 4.1 years (range: 0.4-12.0). TTV and ETV decreased for both the FSRT and SRS groups. However, only the FSRT group achieved significant tumour shrinkage (p < 0.015 for TTV, p < 0.005 for ETV over time). The 11 NRs showed proportionally greater TTV (median TTV pre-treatment: 0.61 cm(3), 8-10 years after: 1.77 cm(3)) and ETV despite radiation therapy compared to responders (median TTV pre-treatment: 1.06 cm(3); 10-12 years after: 0.81 cm(3); p = 0.001).CONCLUSION: 3D quantification of VS showed a significant decrease in TTV and ETV on FSRT-treated patients only. NR had significantly greater TTV and ETV over time.KEY POINTS: • Only FSRT not GK-treated patients showed significant tumour shrinkage over time. • Clinical non-responders showed significantly less tumour shrinkage when compared to responders. • 3D volumetric assessment of vestibular schwannoma shows advantages over unidimensional techniques.

U2 - 10.1007/s00330-015-3895-9

DO - 10.1007/s00330-015-3895-9

M3 - SCORING: Journal article

C2 - 26139318

VL - 26

SP - 849

EP - 857

JO - EUR RADIOL

JF - EUR RADIOL

SN - 0938-7994

IS - 3

ER -