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α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders

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α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders. / Kurt, Simone; Zuccotti, Annalisa; Pirone, Antonella; Rüttiger, Lukas; Pilz, Peter; Brown, David H; Franz, Christoph; Schweizer, Michaela; Rust, Marco B; Rübsamen, Rudolf; Friauf, Eckhard; Knipper, Marlies; Engel, Jutta.

in: J NEUROSCI, Jahrgang 34, Nr. 2, 2014, S. 434-45.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kurt, S, Zuccotti, A, Pirone, A, Rüttiger, L, Pilz, P, Brown, DH, Franz, C, Schweizer, M, Rust, MB, Rübsamen, R, Friauf, E, Knipper, M & Engel, J 2014, 'α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders', J NEUROSCI, Jg. 34, Nr. 2, S. 434-45. https://doi.org/10.1523/JNEUROSCI.3085-13.2014

APA

Kurt, S., Zuccotti, A., Pirone, A., Rüttiger, L., Pilz, P., Brown, D. H., Franz, C., Schweizer, M., Rust, M. B., Rübsamen, R., Friauf, E., Knipper, M., & Engel, J. (2014). α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders. J NEUROSCI, 34(2), 434-45. https://doi.org/10.1523/JNEUROSCI.3085-13.2014

Vancouver

Kurt S, Zuccotti A, Pirone A, Rüttiger L, Pilz P, Brown DH et al. α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders. J NEUROSCI. 2014;34(2):434-45. https://doi.org/10.1523/JNEUROSCI.3085-13.2014

Bibtex

@article{bfaa9feae5c34db1bb45e89d9fa24077,
title = "α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders",
abstract = "The auxiliary subunit α2δ3 modulates the expression and function of voltage-gated calcium channels. Here we show that α2δ3 mRNA is expressed in spiral ganglion neurons and auditory brainstem nuclei and that the protein is required for normal acoustic responses. Genetic deletion of α2δ3 led to impaired auditory processing, with reduced acoustic startle and distorted auditory brainstem responses. α2δ3(-/-) mice learned to discriminate pure tones, but they failed to discriminate temporally structured amplitude-modulated tones. Light and electron microscopy analyses revealed reduced levels of presynaptic Ca(2+) channels and smaller auditory nerve fiber terminals contacting cochlear nucleus bushy cells. Juxtacellular in vivo recordings of sound-evoked activity in α2δ3(-/-) mice demonstrated impaired transmission at these synapses. Together, our results identify a novel role for the α2δ3 auxiliary subunit in the structure and function of specific synapses in the mammalian auditory pathway and in auditory processing disorders.",
keywords = "Animals, Auditory Perceptual Disorders, Brain Stem, Calcium Channels, Cochlear Nerve, Discrimination Learning, Electrophysiology, Evoked Potentials, Auditory, Brain Stem, Immunohistochemistry, In Situ Hybridization, Mice, Mice, Knockout, Microscopy, Electron, Transmission, Reverse Transcriptase Polymerase Chain Reaction, Spiral Ganglion, Synapses, Synaptic Transmission",
author = "Simone Kurt and Annalisa Zuccotti and Antonella Pirone and Lukas R{\"u}ttiger and Peter Pilz and Brown, {David H} and Christoph Franz and Michaela Schweizer and Rust, {Marco B} and Rudolf R{\"u}bsamen and Eckhard Friauf and Marlies Knipper and Jutta Engel",
year = "2014",
doi = "10.1523/JNEUROSCI.3085-13.2014",
language = "English",
volume = "34",
pages = "434--45",
journal = "J NEUROSCI",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "2",

}

RIS

TY - JOUR

T1 - α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders

AU - Kurt, Simone

AU - Zuccotti, Annalisa

AU - Pirone, Antonella

AU - Rüttiger, Lukas

AU - Pilz, Peter

AU - Brown, David H

AU - Franz, Christoph

AU - Schweizer, Michaela

AU - Rust, Marco B

AU - Rübsamen, Rudolf

AU - Friauf, Eckhard

AU - Knipper, Marlies

AU - Engel, Jutta

PY - 2014

Y1 - 2014

N2 - The auxiliary subunit α2δ3 modulates the expression and function of voltage-gated calcium channels. Here we show that α2δ3 mRNA is expressed in spiral ganglion neurons and auditory brainstem nuclei and that the protein is required for normal acoustic responses. Genetic deletion of α2δ3 led to impaired auditory processing, with reduced acoustic startle and distorted auditory brainstem responses. α2δ3(-/-) mice learned to discriminate pure tones, but they failed to discriminate temporally structured amplitude-modulated tones. Light and electron microscopy analyses revealed reduced levels of presynaptic Ca(2+) channels and smaller auditory nerve fiber terminals contacting cochlear nucleus bushy cells. Juxtacellular in vivo recordings of sound-evoked activity in α2δ3(-/-) mice demonstrated impaired transmission at these synapses. Together, our results identify a novel role for the α2δ3 auxiliary subunit in the structure and function of specific synapses in the mammalian auditory pathway and in auditory processing disorders.

AB - The auxiliary subunit α2δ3 modulates the expression and function of voltage-gated calcium channels. Here we show that α2δ3 mRNA is expressed in spiral ganglion neurons and auditory brainstem nuclei and that the protein is required for normal acoustic responses. Genetic deletion of α2δ3 led to impaired auditory processing, with reduced acoustic startle and distorted auditory brainstem responses. α2δ3(-/-) mice learned to discriminate pure tones, but they failed to discriminate temporally structured amplitude-modulated tones. Light and electron microscopy analyses revealed reduced levels of presynaptic Ca(2+) channels and smaller auditory nerve fiber terminals contacting cochlear nucleus bushy cells. Juxtacellular in vivo recordings of sound-evoked activity in α2δ3(-/-) mice demonstrated impaired transmission at these synapses. Together, our results identify a novel role for the α2δ3 auxiliary subunit in the structure and function of specific synapses in the mammalian auditory pathway and in auditory processing disorders.

KW - Animals

KW - Auditory Perceptual Disorders

KW - Brain Stem

KW - Calcium Channels

KW - Cochlear Nerve

KW - Discrimination Learning

KW - Electrophysiology

KW - Evoked Potentials, Auditory, Brain Stem

KW - Immunohistochemistry

KW - In Situ Hybridization

KW - Mice

KW - Mice, Knockout

KW - Microscopy, Electron, Transmission

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Spiral Ganglion

KW - Synapses

KW - Synaptic Transmission

U2 - 10.1523/JNEUROSCI.3085-13.2014

DO - 10.1523/JNEUROSCI.3085-13.2014

M3 - SCORING: Journal article

C2 - 24403143

VL - 34

SP - 434

EP - 445

JO - J NEUROSCI

JF - J NEUROSCI

SN - 0270-6474

IS - 2

ER -