2018 international consensus meeting on musculoskeletal infection: Summary from the Biofilm Workgroup and consensus on Biofilm related Musculoskeletal Infections
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2018 international consensus meeting on musculoskeletal infection: Summary from the Biofilm Workgroup and consensus on Biofilm related Musculoskeletal Infections. / Saeed, Kordo; McLaren, Alex C; Schwarz, Edward M; Antoci, Valentin; Arnold, William V; Chen, Antonia F; Clauss, Martin; Esteban, Jaime; Gant, Vanya; Hendershot, Edward; Hickok, Noreen; Higuera, Carlos A; Coraça-Huber, Débora C; Choe, Hyonmin; Jennings, Jessica Amber; Joshi, Manjari; Li, William T; Noble, Philip C; Phillips, K Scott; Pottinger, Paul S; Restrepo, Camilo; Rohde, Holger; Schaer, Thomas P; Shen, Hao; Smeltzer, Mark; Stoodley, Paul; Webb, Jason C J; Witsø, Eivind.
in: J ORTHOP RES, Jahrgang 37, Nr. 5, 05.2019, S. 1007-1017.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - 2018 international consensus meeting on musculoskeletal infection: Summary from the Biofilm Workgroup and consensus on Biofilm related Musculoskeletal Infections
AU - Saeed, Kordo
AU - McLaren, Alex C
AU - Schwarz, Edward M
AU - Antoci, Valentin
AU - Arnold, William V
AU - Chen, Antonia F
AU - Clauss, Martin
AU - Esteban, Jaime
AU - Gant, Vanya
AU - Hendershot, Edward
AU - Hickok, Noreen
AU - Higuera, Carlos A
AU - Coraça-Huber, Débora C
AU - Choe, Hyonmin
AU - Jennings, Jessica Amber
AU - Joshi, Manjari
AU - Li, William T
AU - Noble, Philip C
AU - Phillips, K Scott
AU - Pottinger, Paul S
AU - Restrepo, Camilo
AU - Rohde, Holger
AU - Schaer, Thomas P
AU - Shen, Hao
AU - Smeltzer, Mark
AU - Stoodley, Paul
AU - Webb, Jason C J
AU - Witsø, Eivind
N1 - This article is protected by copyright. All rights reserved.
PY - 2019/5
Y1 - 2019/5
N2 - Biofilm-associated implant-related bone and joint infections are clinically important due to the extensive morbidity, cost of care and socioeconomic burden that they cause. Research in the field of biofilms has expanded in the past two decades, however, there is still an immense knowledge gap related to many clinical challenges of these biofilm-associated infections. This subject was assigned to the Biofilm Workgroup during the second International Consensus Meeting on Musculoskeletal Infection held in Philadelphia USA (ICM 2018) (https://icmphilly.com). The main objective of the Biofilm Workgroup was to prepare a consensus document based on a review of the literature, prepared responses, discussion, and vote on thirteen biofilm related questions. The Workgroup commenced discussing and refining responses prepared before the meeting on day one using Delphi methodology, followed by a tally of responses using an anonymized voting system on the second day of ICM 2018. The Working group derived consensus on information about biofilms deemed relevant to clinical practice, pertaining to: (1) surface modifications to prevent/inhibit biofilm formation; (2) therapies to prevent and treat biofilm infections; (3) polymicrobial biofilms; (4) diagnostics to detect active and dormant biofilm in patients; (5) methods to establish minimal biofilm eradication concentration for biofilm bacteria; and (6) novel anti-infectives that are effective against biofilm bacteria. It was also noted that biomedical research funding agencies and the pharmaceutical industry should recognize these areas as priorities. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.
AB - Biofilm-associated implant-related bone and joint infections are clinically important due to the extensive morbidity, cost of care and socioeconomic burden that they cause. Research in the field of biofilms has expanded in the past two decades, however, there is still an immense knowledge gap related to many clinical challenges of these biofilm-associated infections. This subject was assigned to the Biofilm Workgroup during the second International Consensus Meeting on Musculoskeletal Infection held in Philadelphia USA (ICM 2018) (https://icmphilly.com). The main objective of the Biofilm Workgroup was to prepare a consensus document based on a review of the literature, prepared responses, discussion, and vote on thirteen biofilm related questions. The Workgroup commenced discussing and refining responses prepared before the meeting on day one using Delphi methodology, followed by a tally of responses using an anonymized voting system on the second day of ICM 2018. The Working group derived consensus on information about biofilms deemed relevant to clinical practice, pertaining to: (1) surface modifications to prevent/inhibit biofilm formation; (2) therapies to prevent and treat biofilm infections; (3) polymicrobial biofilms; (4) diagnostics to detect active and dormant biofilm in patients; (5) methods to establish minimal biofilm eradication concentration for biofilm bacteria; and (6) novel anti-infectives that are effective against biofilm bacteria. It was also noted that biomedical research funding agencies and the pharmaceutical industry should recognize these areas as priorities. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.
KW - Journal Article
U2 - 10.1002/jor.24229
DO - 10.1002/jor.24229
M3 - SCORING: Journal article
C2 - 30667567
VL - 37
SP - 1007
EP - 1017
JO - J ORTHOP RES
JF - J ORTHOP RES
SN - 0736-0266
IS - 5
ER -