11q21 rearrangement is a frequent and highly specific genetic alteration in mucoepidermoid carcinoma
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11q21 rearrangement is a frequent and highly specific genetic alteration in mucoepidermoid carcinoma. / Clauditz, Till; Gontarewicz, Artur; Wang, Chia-Jung; Münscher, Adrian; Laban, Simon; Tsourlakis, Maria Christina; Knecht, Rainald; Sauter, Guido; Wilczak, Waldemar.
in: DIAGN MOL PATHOL, Jahrgang 21, Nr. 3, 3, 2012, S. 134-137.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - 11q21 rearrangement is a frequent and highly specific genetic alteration in mucoepidermoid carcinoma
AU - Clauditz, Till
AU - Gontarewicz, Artur
AU - Wang, Chia-Jung
AU - Münscher, Adrian
AU - Laban, Simon
AU - Tsourlakis, Maria Christina
AU - Knecht, Rainald
AU - Sauter, Guido
AU - Wilczak, Waldemar
PY - 2012
Y1 - 2012
N2 - Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. Translocation t(11;19)(q21;p13) involving the MECT1 and MAML2 genes has been suggested as a diagnostic marker in these tumors. To determine the specificity of 11q21 locus rearrangements for MEC, fluorescence in situ hybridization analysis with specific MEC-I Dual Color Break Apart Probe was performed on a tissue microarray containing samples from almost 1200 salivary gland adenomas and carcinomas. Rearrangements of 11q21 were observed in 40% of 217 MECs. The frequency of rearrangements decreased with tumor grade and was found in 53% of G1, 43% of G2, and 31% of G3 tumors (P=0.015). There were no 11q21 rearrangements found in other salivary gland carcinomas including 142 adenoid cystic carcinomas, 104 acinic cell adenocarcinomas, 76 adenocarcinoma not otherwise specified, 38 epithelial-myoepithelial carcinomas, 15 polymorphous low-grade adenocarcinomas, 18 basal cell adenocarcinomas, 19 myoepithelial carcinomas, 12 papillary cystadenocarcinomas, 6 salivary duct carcinomas, and 10 oncocytic carcinomas. Furthermore, all analyzed salivary gland adenomas, including 39 cases of Warthin tumor and control samples, either from the salivary gland or from other organs were negative for 11q21 rearrangements. It is concluded that MECT1-MAML2 gene fusion is a highly specific genetic alteration in MEC with predominance in low-grade and intermediate-grade tumors.
AB - Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. Translocation t(11;19)(q21;p13) involving the MECT1 and MAML2 genes has been suggested as a diagnostic marker in these tumors. To determine the specificity of 11q21 locus rearrangements for MEC, fluorescence in situ hybridization analysis with specific MEC-I Dual Color Break Apart Probe was performed on a tissue microarray containing samples from almost 1200 salivary gland adenomas and carcinomas. Rearrangements of 11q21 were observed in 40% of 217 MECs. The frequency of rearrangements decreased with tumor grade and was found in 53% of G1, 43% of G2, and 31% of G3 tumors (P=0.015). There were no 11q21 rearrangements found in other salivary gland carcinomas including 142 adenoid cystic carcinomas, 104 acinic cell adenocarcinomas, 76 adenocarcinoma not otherwise specified, 38 epithelial-myoepithelial carcinomas, 15 polymorphous low-grade adenocarcinomas, 18 basal cell adenocarcinomas, 19 myoepithelial carcinomas, 12 papillary cystadenocarcinomas, 6 salivary duct carcinomas, and 10 oncocytic carcinomas. Furthermore, all analyzed salivary gland adenomas, including 39 cases of Warthin tumor and control samples, either from the salivary gland or from other organs were negative for 11q21 rearrangements. It is concluded that MECT1-MAML2 gene fusion is a highly specific genetic alteration in MEC with predominance in low-grade and intermediate-grade tumors.
KW - Humans
KW - In Situ Hybridization, Fluorescence
KW - Microarray Analysis
KW - Oncogene Proteins, Fusion/genetics
KW - Translocation, Genetic
KW - Tumor Markers, Biological/genetics
KW - Chromosomes, Human, Pair 19/genetics
KW - Adenoma/diagnosis
KW - Carcinoma, Mucoepidermoid/diagnosis
KW - Chromosomes, Human, Pair 11/genetics
KW - Salivary Gland Neoplasms/diagnosis
KW - Humans
KW - In Situ Hybridization, Fluorescence
KW - Microarray Analysis
KW - Oncogene Proteins, Fusion/genetics
KW - Translocation, Genetic
KW - Tumor Markers, Biological/genetics
KW - Chromosomes, Human, Pair 19/genetics
KW - Adenoma/diagnosis
KW - Carcinoma, Mucoepidermoid/diagnosis
KW - Chromosomes, Human, Pair 11/genetics
KW - Salivary Gland Neoplasms/diagnosis
U2 - 10.1097/PDM.0b013e318255552c
DO - 10.1097/PDM.0b013e318255552c
M3 - SCORING: Journal article
C2 - 22847156
VL - 21
SP - 134
EP - 137
JO - DIAGN MOL PATHOL
JF - DIAGN MOL PATHOL
SN - 1052-9551
IS - 3
M1 - 3
ER -
