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11q13 is a susceptibility locus for hormone receptor positive breast cancer.

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11q13 is a susceptibility locus for hormone receptor positive breast cancer. / Lambrechts, Diether; Truong, Therese; Justenhoven, Christina; Humphreys, Manjeet K; Wang, Jean; Hopper, John L; Dite, Gillian S; Apicella, Carmel; Southey, Melissa C; Schmidt, Marjanka K; Broeks, Annegien; Cornelissen, Sten; van Hien, Richard; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael; Miller, Nicola; Milne, Roger L; Zamora, M Pilar; Pérez, José Ignacio Arias; Benítez, Javier; Hamann, Ute; Ko, Yon-Dschun; Brüning, Thomas; Network, GENICA; Chang-Claude, Jenny; Eilber, Ursel; Hein, Rebecca; Nickels, Stefan; Flesch-Janys, Dieter; Wang-Gohrke, Shan; John, Esther M; Miron, Alexander; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Chenevix-Trench, Georgia; Beesley, Jonathan; Chen, Xiaoqing; Group, Australian Ovarian Cancer Study; Menegaux, Florence; Cordina-Duverger, Emilie; Shen, Chen-Yang; Yu, Jyh-Cherng; Wu, Pei-Ei; Hou, Ming-Feng; Andrulis, Irene L; Selander, Teresa; Glendon, Gord; Mulligan, Anna Marie; Anton-Culver, Hoda; Ziogas, Argyrios; Muir, Kenneth R; Lophatananon, Artitaya; Rattanamongkongul, Suthee; Puttawibul, Puttisak; Jones, Michael; Orr, Nicholas; Ashworth, Alan; Swerdlow, Anthony; Severi, Gianluca; Baglietto, Laura; Giles, Graham; Southey, Melissa; Marmé, Federik; Schneeweiss, Andreas; Sohn, Christof; Burwinkel, Barbara; Yesilyurt, Betul T; Neven, Patrick; Paridaens, Robert; Wildiers, Hans; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Meindl, Alfons; Schott, Sarah; Bartram, Claus R; Schmutzler, Rita K; Cox, Angela; Brock, Ian W; Elliott, Graeme; Cross, Simon S; Fasching, Peter A; Schulz-Wendtland, Ruediger; Ekici, Arif B; Beckmann, Matthias W; Fletcher, Olivia; Johnson, Nichola; Silva, Isabel Dos Santos; Peto, Julian; Nevanlinna, Heli; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Dörk, Thilo; Schürmann, Peter; Bremer, Michael; Hillemanns, Peter; Bogdanova, Natalia V; Antonenkova, Natalia N; Rogov, Yuri I; Karstens, Johann H; Khusnutdinova, Elza; Bermisheva, Marina; Prokofieva, Darya; Gancev, Shamil; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Nordestgaard, Børge G; Bojesen, Stig E; Lanng, Charlotte; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Bernard, Loris; Couch, Fergus J; Olson, Janet E; Wang, Xianshu; Fredericksen, Zachary; Alnaes, Grethe Grenaker; Kristensen, Vessela; Børresen-Dale, Anne-Lise; Devilee, Peter; Tollenaar, Robert A E M; Seynaeve, Caroline M; Hooning, Maartje J; García-Closas, Montserrat; Chanock, Stephen J; Lissowska, Jolanta; Sherman, Mark E; Hall, Per; Liu, Jianjun; Czene, Kamila; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Lindblom, Annika; Margolin, Sara; Dunning, Alison M; Pharoah, Paul D P; Easton, Douglas F; Guénel, Pascal; Brauch, Hiltrud.

in: HUM MUTAT, Jahrgang 33, Nr. 7, 7, 2012, S. 1123-1132.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lambrechts, D, Truong, T, Justenhoven, C, Humphreys, MK, Wang, J, Hopper, JL, Dite, GS, Apicella, C, Southey, MC, Schmidt, MK, Broeks, A, Cornelissen, S, van Hien, R, Sawyer, E, Tomlinson, I, Kerin, M, Miller, N, Milne, RL, Zamora, MP, Pérez, JIA, Benítez, J, Hamann, U, Ko, Y-D, Brüning, T, Network, GENICA, Chang-Claude, J, Eilber, U, Hein, R, Nickels, S, Flesch-Janys, D, Wang-Gohrke, S, John, EM, Miron, A, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Chenevix-Trench, G, Beesley, J, Chen, X, Group, AOCS, Menegaux, F, Cordina-Duverger, E, Shen, C-Y, Yu, J-C, Wu, P-E, Hou, M-F, Andrulis, IL, Selander, T, Glendon, G, Mulligan, AM, Anton-Culver, H, Ziogas, A, Muir, KR, Lophatananon, A, Rattanamongkongul, S, Puttawibul, P, Jones, M, Orr, N, Ashworth, A, Swerdlow, A, Severi, G, Baglietto, L, Giles, G, Southey, M, Marmé, F, Schneeweiss, A, Sohn, C, Burwinkel, B, Yesilyurt, BT, Neven, P, Paridaens, R, Wildiers, H, Brenner, H, Müller, H, Arndt, V, Stegmaier, C, Meindl, A, Schott, S, Bartram, CR, Schmutzler, RK, Cox, A, Brock, IW, Elliott, G, Cross, SS, Fasching, PA, Schulz-Wendtland, R, Ekici, AB, Beckmann, MW, Fletcher, O, Johnson, N, Silva, IDS, Peto, J, Nevanlinna, H, Muranen, TA, Aittomäki, K, Blomqvist, C, Dörk, T, Schürmann, P, Bremer, M, Hillemanns, P, Bogdanova, NV, Antonenkova, NN, Rogov, YI, Karstens, JH, Khusnutdinova, E, Bermisheva, M, Prokofieva, D, Gancev, S, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Nordestgaard, BG, Bojesen, SE, Lanng, C, Mannermaa, A, Kataja, V, Kosma, V-M, Hartikainen, JM, Radice, P, Peterlongo, P, Manoukian, S, Bernard, L, Couch, FJ, Olson, JE, Wang, X, Fredericksen, Z, Alnaes, GG, Kristensen, V, Børresen-Dale, A-L, Devilee, P, Tollenaar, RAEM, Seynaeve, CM, Hooning, MJ, García-Closas, M, Chanock, SJ, Lissowska, J, Sherman, ME, Hall, P, Liu, J, Czene, K, Kang, D, Yoo, K-Y, Noh, D-Y, Lindblom, A, Margolin, S, Dunning, AM, Pharoah, PDP, Easton, DF, Guénel, P & Brauch, H 2012, '11q13 is a susceptibility locus for hormone receptor positive breast cancer.', HUM MUTAT, Jg. 33, Nr. 7, 7, S. 1123-1132. <http://www.ncbi.nlm.nih.gov/pubmed/22461340?dopt=Citation>

APA

Lambrechts, D., Truong, T., Justenhoven, C., Humphreys, M. K., Wang, J., Hopper, J. L., Dite, G. S., Apicella, C., Southey, M. C., Schmidt, M. K., Broeks, A., Cornelissen, S., van Hien, R., Sawyer, E., Tomlinson, I., Kerin, M., Miller, N., Milne, R. L., Zamora, M. P., ... Brauch, H. (2012). 11q13 is a susceptibility locus for hormone receptor positive breast cancer. HUM MUTAT, 33(7), 1123-1132. [7]. http://www.ncbi.nlm.nih.gov/pubmed/22461340?dopt=Citation

Vancouver

Lambrechts D, Truong T, Justenhoven C, Humphreys MK, Wang J, Hopper JL et al. 11q13 is a susceptibility locus for hormone receptor positive breast cancer. HUM MUTAT. 2012;33(7):1123-1132. 7.

Bibtex

@article{f3e43e76c8404dcfab86bc4b81ca2b60,
title = "11q13 is a susceptibility locus for hormone receptor positive breast cancer.",
abstract = "A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P ? 3 × 10(-9) ) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10(-39) ). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.",
keywords = "Humans, Female, Risk Factors, Genotype, European Continental Ancestry Group, Genome-Wide Association Study, Breast Neoplasms/*genetics, Polymorphism, Single Nucleotide/genetics, Receptors, Estrogen/*genetics, Receptors, Progesterone/*genetics, Genetic Predisposition to Disease/genetics, Chromosomes, Human, Pair 11/*genetics, Humans, Female, Risk Factors, Genotype, European Continental Ancestry Group, Genome-Wide Association Study, Breast Neoplasms/*genetics, Polymorphism, Single Nucleotide/genetics, Receptors, Estrogen/*genetics, Receptors, Progesterone/*genetics, Genetic Predisposition to Disease/genetics, Chromosomes, Human, Pair 11/*genetics",
author = "Diether Lambrechts and Therese Truong and Christina Justenhoven and Humphreys, {Manjeet K} and Jean Wang and Hopper, {John L} and Dite, {Gillian S} and Carmel Apicella and Southey, {Melissa C} and Schmidt, {Marjanka K} and Annegien Broeks and Sten Cornelissen and {van Hien}, Richard and Elinor Sawyer and Ian Tomlinson and Michael Kerin and Nicola Miller and Milne, {Roger L} and Zamora, {M Pilar} and P{\'e}rez, {Jos{\'e} Ignacio Arias} and Javier Ben{\'i}tez and Ute Hamann and Yon-Dschun Ko and Thomas Br{\"u}ning and GENICA Network and Jenny Chang-Claude and Ursel Eilber and Rebecca Hein and Stefan Nickels and Dieter Flesch-Janys and Shan Wang-Gohrke and John, {Esther M} and Alexander Miron and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Georgia Chenevix-Trench and Jonathan Beesley and Xiaoqing Chen and Group, {Australian Ovarian Cancer Study} and Florence Menegaux and Emilie Cordina-Duverger and Chen-Yang Shen and Jyh-Cherng Yu and Pei-Ei Wu and Ming-Feng Hou and Andrulis, {Irene L} and Teresa Selander and Gord Glendon and Mulligan, {Anna Marie} and Hoda Anton-Culver and Argyrios Ziogas and Muir, {Kenneth R} and Artitaya Lophatananon and Suthee Rattanamongkongul and Puttisak Puttawibul and Michael Jones and Nicholas Orr and Alan Ashworth and Anthony Swerdlow and Gianluca Severi and Laura Baglietto and Graham Giles and Melissa Southey and Federik Marm{\'e} and Andreas Schneeweiss and Christof Sohn and Barbara Burwinkel and Yesilyurt, {Betul T} and Patrick Neven and Robert Paridaens and Hans Wildiers and Hermann Brenner and Heiko M{\"u}ller and Volker Arndt and Christa Stegmaier and Alfons Meindl and Sarah Schott and Bartram, {Claus R} and Schmutzler, {Rita K} and Angela Cox and Brock, {Ian W} and Graeme Elliott and Cross, {Simon S} and Fasching, {Peter A} and Ruediger Schulz-Wendtland and Ekici, {Arif B} and Beckmann, {Matthias W} and Olivia Fletcher and Nichola Johnson and Silva, {Isabel Dos Santos} and Julian Peto and Heli Nevanlinna and Muranen, {Taru A} and Kristiina Aittom{\"a}ki and Carl Blomqvist and Thilo D{\"o}rk and Peter Sch{\"u}rmann and Michael Bremer and Peter Hillemanns and Bogdanova, {Natalia V} and Antonenkova, {Natalia N} and Rogov, {Yuri I} and Karstens, {Johann H} and Elza Khusnutdinova and Marina Bermisheva and Darya Prokofieva and Shamil Gancev and Anna Jakubowska and Jan Lubinski and Katarzyna Jaworska and Katarzyna Durda and Nordestgaard, {B{\o}rge G} and Bojesen, {Stig E} and Charlotte Lanng and Arto Mannermaa and Vesa Kataja and Veli-Matti Kosma and Hartikainen, {Jaana M} and Paolo Radice and Paolo Peterlongo and Siranoush Manoukian and Loris Bernard and Couch, {Fergus J} and Olson, {Janet E} and Xianshu Wang and Zachary Fredericksen and Alnaes, {Grethe Grenaker} and Vessela Kristensen and Anne-Lise B{\o}rresen-Dale and Peter Devilee and Tollenaar, {Robert A E M} and Seynaeve, {Caroline M} and Hooning, {Maartje J} and Montserrat Garc{\'i}a-Closas and Chanock, {Stephen J} and Jolanta Lissowska and Sherman, {Mark E} and Per Hall and Jianjun Liu and Kamila Czene and Daehee Kang and Keun-Young Yoo and Dong-Young Noh and Annika Lindblom and Sara Margolin and Dunning, {Alison M} and Pharoah, {Paul D P} and Easton, {Douglas F} and Pascal Gu{\'e}nel and Hiltrud Brauch",
year = "2012",
language = "English",
volume = "33",
pages = "1123--1132",
journal = "HUM MUTAT",
issn = "1059-7794",
publisher = "Wiley-Liss Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - 11q13 is a susceptibility locus for hormone receptor positive breast cancer.

AU - Lambrechts, Diether

AU - Truong, Therese

AU - Justenhoven, Christina

AU - Humphreys, Manjeet K

AU - Wang, Jean

AU - Hopper, John L

AU - Dite, Gillian S

AU - Apicella, Carmel

AU - Southey, Melissa C

AU - Schmidt, Marjanka K

AU - Broeks, Annegien

AU - Cornelissen, Sten

AU - van Hien, Richard

AU - Sawyer, Elinor

AU - Tomlinson, Ian

AU - Kerin, Michael

AU - Miller, Nicola

AU - Milne, Roger L

AU - Zamora, M Pilar

AU - Pérez, José Ignacio Arias

AU - Benítez, Javier

AU - Hamann, Ute

AU - Ko, Yon-Dschun

AU - Brüning, Thomas

AU - Network, GENICA

AU - Chang-Claude, Jenny

AU - Eilber, Ursel

AU - Hein, Rebecca

AU - Nickels, Stefan

AU - Flesch-Janys, Dieter

AU - Wang-Gohrke, Shan

AU - John, Esther M

AU - Miron, Alexander

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Grip, Mervi

AU - Chenevix-Trench, Georgia

AU - Beesley, Jonathan

AU - Chen, Xiaoqing

AU - Group, Australian Ovarian Cancer Study

AU - Menegaux, Florence

AU - Cordina-Duverger, Emilie

AU - Shen, Chen-Yang

AU - Yu, Jyh-Cherng

AU - Wu, Pei-Ei

AU - Hou, Ming-Feng

AU - Andrulis, Irene L

AU - Selander, Teresa

AU - Glendon, Gord

AU - Mulligan, Anna Marie

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Muir, Kenneth R

AU - Lophatananon, Artitaya

AU - Rattanamongkongul, Suthee

AU - Puttawibul, Puttisak

AU - Jones, Michael

AU - Orr, Nicholas

AU - Ashworth, Alan

AU - Swerdlow, Anthony

AU - Severi, Gianluca

AU - Baglietto, Laura

AU - Giles, Graham

AU - Southey, Melissa

AU - Marmé, Federik

AU - Schneeweiss, Andreas

AU - Sohn, Christof

AU - Burwinkel, Barbara

AU - Yesilyurt, Betul T

AU - Neven, Patrick

AU - Paridaens, Robert

AU - Wildiers, Hans

AU - Brenner, Hermann

AU - Müller, Heiko

AU - Arndt, Volker

AU - Stegmaier, Christa

AU - Meindl, Alfons

AU - Schott, Sarah

AU - Bartram, Claus R

AU - Schmutzler, Rita K

AU - Cox, Angela

AU - Brock, Ian W

AU - Elliott, Graeme

AU - Cross, Simon S

AU - Fasching, Peter A

AU - Schulz-Wendtland, Ruediger

AU - Ekici, Arif B

AU - Beckmann, Matthias W

AU - Fletcher, Olivia

AU - Johnson, Nichola

AU - Silva, Isabel Dos Santos

AU - Peto, Julian

AU - Nevanlinna, Heli

AU - Muranen, Taru A

AU - Aittomäki, Kristiina

AU - Blomqvist, Carl

AU - Dörk, Thilo

AU - Schürmann, Peter

AU - Bremer, Michael

AU - Hillemanns, Peter

AU - Bogdanova, Natalia V

AU - Antonenkova, Natalia N

AU - Rogov, Yuri I

AU - Karstens, Johann H

AU - Khusnutdinova, Elza

AU - Bermisheva, Marina

AU - Prokofieva, Darya

AU - Gancev, Shamil

AU - Jakubowska, Anna

AU - Lubinski, Jan

AU - Jaworska, Katarzyna

AU - Durda, Katarzyna

AU - Nordestgaard, Børge G

AU - Bojesen, Stig E

AU - Lanng, Charlotte

AU - Mannermaa, Arto

AU - Kataja, Vesa

AU - Kosma, Veli-Matti

AU - Hartikainen, Jaana M

AU - Radice, Paolo

AU - Peterlongo, Paolo

AU - Manoukian, Siranoush

AU - Bernard, Loris

AU - Couch, Fergus J

AU - Olson, Janet E

AU - Wang, Xianshu

AU - Fredericksen, Zachary

AU - Alnaes, Grethe Grenaker

AU - Kristensen, Vessela

AU - Børresen-Dale, Anne-Lise

AU - Devilee, Peter

AU - Tollenaar, Robert A E M

AU - Seynaeve, Caroline M

AU - Hooning, Maartje J

AU - García-Closas, Montserrat

AU - Chanock, Stephen J

AU - Lissowska, Jolanta

AU - Sherman, Mark E

AU - Hall, Per

AU - Liu, Jianjun

AU - Czene, Kamila

AU - Kang, Daehee

AU - Yoo, Keun-Young

AU - Noh, Dong-Young

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Dunning, Alison M

AU - Pharoah, Paul D P

AU - Easton, Douglas F

AU - Guénel, Pascal

AU - Brauch, Hiltrud

PY - 2012

Y1 - 2012

N2 - A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P ? 3 × 10(-9) ) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10(-39) ). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.

AB - A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P ? 3 × 10(-9) ) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10(-39) ). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.

KW - Humans

KW - Female

KW - Risk Factors

KW - Genotype

KW - European Continental Ancestry Group

KW - Genome-Wide Association Study

KW - Breast Neoplasms/genetics

KW - Polymorphism, Single Nucleotide/genetics

KW - Receptors, Estrogen/genetics

KW - Receptors, Progesterone/genetics

KW - Genetic Predisposition to Disease/genetics

KW - Chromosomes, Human, Pair 11/genetics

KW - Humans

KW - Female

KW - Risk Factors

KW - Genotype

KW - European Continental Ancestry Group

KW - Genome-Wide Association Study

KW - Breast Neoplasms/genetics

KW - Polymorphism, Single Nucleotide/genetics

KW - Receptors, Estrogen/genetics

KW - Receptors, Progesterone/genetics

KW - Genetic Predisposition to Disease/genetics

KW - Chromosomes, Human, Pair 11/genetics

M3 - SCORING: Journal article

VL - 33

SP - 1123

EP - 1132

JO - HUM MUTAT

JF - HUM MUTAT

SN - 1059-7794

IS - 7

M1 - 7

ER -