(1 → 3)-β-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial
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(1 → 3)-β-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial. / Bloos, Frank; Held, Jürgen; Kluge, Stefan; Simon, Philipp; Kogelmann, Klaus; de Heer, Geraldine; Kuhn, Sven-Olaf; Jarczak, Dominik; Motsch, Johann; Hempel, Gunther; Weiler, Norbert; Weyland, Andreas; Drüner, Matthias; Gründling, Matthias; Meybohm, Patrick; Richter, Daniel; Jaschinski, Ulrich; Moerer, Onnen; Günther, Ulf; Schädler, Dirk; Weiss, Raphael; Putensen, Christian; Castellanos, Ixchel; Kurzai, Oliver; Schlattmann, Peter; Cornely, Oliver A; Bauer, Michael; Thomas-Rüddel, Daniel; SepNet Study Group.
in: INTENS CARE MED, Jahrgang 48, Nr. 7, 07.2022, S. 865-875.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - (1 → 3)-β-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial
AU - Bloos, Frank
AU - Held, Jürgen
AU - Kluge, Stefan
AU - Simon, Philipp
AU - Kogelmann, Klaus
AU - de Heer, Geraldine
AU - Kuhn, Sven-Olaf
AU - Jarczak, Dominik
AU - Motsch, Johann
AU - Hempel, Gunther
AU - Weiler, Norbert
AU - Weyland, Andreas
AU - Drüner, Matthias
AU - Gründling, Matthias
AU - Meybohm, Patrick
AU - Richter, Daniel
AU - Jaschinski, Ulrich
AU - Moerer, Onnen
AU - Günther, Ulf
AU - Schädler, Dirk
AU - Weiss, Raphael
AU - Putensen, Christian
AU - Castellanos, Ixchel
AU - Kurzai, Oliver
AU - Schlattmann, Peter
AU - Cornely, Oliver A
AU - Bauer, Michael
AU - Thomas-Rüddel, Daniel
AU - SepNet Study Group
PY - 2022/7
Y1 - 2022/7
N2 - PURPOSE: To investigate whether (1 → 3)-β-d-Glucan (BDG)-guidance shortens time to antifungal therapy and thereby reduces mortality of sepsis patients with high risk of invasive Candida infection (ICI).METHODS: Multicenter, randomized, controlled trial carried out between September 2016 and September 2019 in 18 intensive care units enrolling adult sepsis patients at high risk for ICI. Patients in the control group received targeted antifungal therapy driven by culture results. In addition to targeted therapy, patients in the BDG group received antifungals if at least one of two consecutive BDG samples taken during the first two study days was ≥ 80 pg/mL. Empirical antifungal therapy was discouraged in both groups. The primary endpoint was 28-day-mortality.RESULTS: 339 patients were enrolled. ICI was diagnosed in 48 patients (14.2%) within the first 96 h after enrollment. In the BDG-group, 48.8% (84/172) patients received antifungals during the first 96 h after enrollment and 6% (10/167) patients in the control group. Death until day 28 occurred in 58 of 172 patients (33.7%) in the BDG group and 51 of 167 patients (30.5%) in the control group (relative risk 1.10; 95% confidence interval, 0.80-1.51; p = 0.53). Median time to antifungal therapy was 1.1 [interquartile range (IQR) 1.0-2.2] days in the BDG group and 4.4 (IQR 2.0-9.1, p < 0.01) days in the control group.CONCLUSIONS: Serum BDG guided antifungal treatment did not improve 28-day mortality among sepsis patients with risk factors for but unexpected low rate of IC. This study cannot comment on the potential benefit of BDG-guidance in a more selected at-risk population.
AB - PURPOSE: To investigate whether (1 → 3)-β-d-Glucan (BDG)-guidance shortens time to antifungal therapy and thereby reduces mortality of sepsis patients with high risk of invasive Candida infection (ICI).METHODS: Multicenter, randomized, controlled trial carried out between September 2016 and September 2019 in 18 intensive care units enrolling adult sepsis patients at high risk for ICI. Patients in the control group received targeted antifungal therapy driven by culture results. In addition to targeted therapy, patients in the BDG group received antifungals if at least one of two consecutive BDG samples taken during the first two study days was ≥ 80 pg/mL. Empirical antifungal therapy was discouraged in both groups. The primary endpoint was 28-day-mortality.RESULTS: 339 patients were enrolled. ICI was diagnosed in 48 patients (14.2%) within the first 96 h after enrollment. In the BDG-group, 48.8% (84/172) patients received antifungals during the first 96 h after enrollment and 6% (10/167) patients in the control group. Death until day 28 occurred in 58 of 172 patients (33.7%) in the BDG group and 51 of 167 patients (30.5%) in the control group (relative risk 1.10; 95% confidence interval, 0.80-1.51; p = 0.53). Median time to antifungal therapy was 1.1 [interquartile range (IQR) 1.0-2.2] days in the BDG group and 4.4 (IQR 2.0-9.1, p < 0.01) days in the control group.CONCLUSIONS: Serum BDG guided antifungal treatment did not improve 28-day mortality among sepsis patients with risk factors for but unexpected low rate of IC. This study cannot comment on the potential benefit of BDG-guidance in a more selected at-risk population.
U2 - 10.1007/s00134-022-06733-x
DO - 10.1007/s00134-022-06733-x
M3 - SCORING: Journal article
C2 - 35708758
VL - 48
SP - 865
EP - 875
JO - INTENS CARE MED
JF - INTENS CARE MED
SN - 0342-4642
IS - 7
ER -
