Advanced platform for profiling of therapeutic targets and functional analysis of circulating tumour cells in cancer patients
Projekt: Forschung
Projektleitende
- Pantel, Klaus (Projektleitung)
Einrichtung(en)
Bibliografische Daten
Beschreibung
However, despite the obvious potential of CTCs as biomarker, current CTC capture assays require sophisticated, expensive and complex assay systems, which is the most important bottleneck for a more widespread use of CTCs as liquid biopsy. The assay development in the ongoing ERC PoC Grant CAPTURE-CTC (end: 11/2016) and the successful research on improved methods for molecular characterization of CTCs in the Advanced Investigator Grant DISSECT (end: 07/2016) of the PI has allowed to develop a novel improved platform for CTC detection. To implement our chip into future clinical decision making, we will now focus on the clinical validation of the chip platform including the development of SOPs as basis for kits for expression of therapeutic targets (e.g., PD-L1, estrogen receptor and HER2) and resistance mechanisms (androgen receptor variant 7) in CTCs. Moreover, the establishment of transient CTC cultures from chip-isolated tumor cells will foster drug testing in individual cancer patients.
In conclusion, the CTCapture_2.0 project will be an important prerequisite for successful future commercialization of a novel liquid biopsy assay.
Akronym | CTCapture_2.0 |
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Status | Beendet |
Tatsächlicher Beginn/-es Ende | 01.05.17 → 31.10.18 |