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Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS)

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Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS) : impact on quality of life and therapeutic options. / Körner, Sonja; Hendricks, Melanie; Kollewe, Katja; Zapf, Antonia; Dengler, Reinhard; Silani, Vincenzo; Petri, Susanne.

In: BMC NEUROL, Vol. 13, 12.07.2013, p. 84.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Körner, S, Hendricks, M, Kollewe, K, Zapf, A, Dengler, R, Silani, V & Petri, S 2013, 'Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options', BMC NEUROL, vol. 13, pp. 84. https://doi.org/10.1186/1471-2377-13-84

APA

Körner, S., Hendricks, M., Kollewe, K., Zapf, A., Dengler, R., Silani, V., & Petri, S. (2013). Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options. BMC NEUROL, 13, 84. https://doi.org/10.1186/1471-2377-13-84

Vancouver

Körner S, Hendricks M, Kollewe K, Zapf A, Dengler R, Silani V et al. Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options. BMC NEUROL. 2013 Jul 12;13:84. https://doi.org/10.1186/1471-2377-13-84

Bibtex

@article{b29847c4692b4f6296baac50424f3efb,
title = "Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options",
abstract = "BACKGROUND: Weight loss is a frequent feature in the motor neuron disease Amyotrophic lateral sclerosis (ALS). In this study we investigated possible causes of weight loss in ALS, its impact on mood/quality of life (QOL) and the benefit of high calorie nutritional/other dietary supplements and percutaneous endoscopic gastrostomy (PEG).METHODS: 121 ALS patients were interviewed and answered standardized questionnaires (Beck depression inventory - II, SF36 Health Survey questionnaire, revised ALS functional rating scale). Two years after the initial survey we performed a follow-up interview.RESULTS: In our ALS-cohort, 56.3% of the patients suffered from weight loss. Weight loss had a negative impact on QOL and was associated with a shorter survival. Patients who took high calorie nutritional supplements respectively had a PEG stated a great benefit regarding weight stabilization and/or QOL.38.2% of our patients had significant weight loss without suffering from dysphagia. To clarify the reasons for weight loss in these patients, we compared them with patients without weight loss. The two groups did not differ regarding severity of disease, depression, frontotemporal dementia or fasciculations, but patients with weight loss declared more often increased respiratory work.CONCLUSIONS: Weight loss is a serious issue in ALS and cannot always be attributed to dysphagia. Symptomatic treatment of weight loss (high calorie nutritional supplements and/ or PEG) should be offered more frequently.",
keywords = "Amyotrophic Lateral Sclerosis, Cohort Studies, Deglutition Disorders, Endoscopy, Gastrointestinal, Female, Health Surveys, Humans, Male, Middle Aged, Nutrition Therapy, Outpatients, Quality of Life, Regression Analysis, Surveys and Questionnaires, Weight Loss, Journal Article",
author = "Sonja K{\"o}rner and Melanie Hendricks and Katja Kollewe and Antonia Zapf and Reinhard Dengler and Vincenzo Silani and Susanne Petri",
year = "2013",
month = jul,
day = "12",
doi = "10.1186/1471-2377-13-84",
language = "English",
volume = "13",
pages = "84",
journal = "BMC NEUROL",
issn = "1471-2377",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS)

T2 - impact on quality of life and therapeutic options

AU - Körner, Sonja

AU - Hendricks, Melanie

AU - Kollewe, Katja

AU - Zapf, Antonia

AU - Dengler, Reinhard

AU - Silani, Vincenzo

AU - Petri, Susanne

PY - 2013/7/12

Y1 - 2013/7/12

N2 - BACKGROUND: Weight loss is a frequent feature in the motor neuron disease Amyotrophic lateral sclerosis (ALS). In this study we investigated possible causes of weight loss in ALS, its impact on mood/quality of life (QOL) and the benefit of high calorie nutritional/other dietary supplements and percutaneous endoscopic gastrostomy (PEG).METHODS: 121 ALS patients were interviewed and answered standardized questionnaires (Beck depression inventory - II, SF36 Health Survey questionnaire, revised ALS functional rating scale). Two years after the initial survey we performed a follow-up interview.RESULTS: In our ALS-cohort, 56.3% of the patients suffered from weight loss. Weight loss had a negative impact on QOL and was associated with a shorter survival. Patients who took high calorie nutritional supplements respectively had a PEG stated a great benefit regarding weight stabilization and/or QOL.38.2% of our patients had significant weight loss without suffering from dysphagia. To clarify the reasons for weight loss in these patients, we compared them with patients without weight loss. The two groups did not differ regarding severity of disease, depression, frontotemporal dementia or fasciculations, but patients with weight loss declared more often increased respiratory work.CONCLUSIONS: Weight loss is a serious issue in ALS and cannot always be attributed to dysphagia. Symptomatic treatment of weight loss (high calorie nutritional supplements and/ or PEG) should be offered more frequently.

AB - BACKGROUND: Weight loss is a frequent feature in the motor neuron disease Amyotrophic lateral sclerosis (ALS). In this study we investigated possible causes of weight loss in ALS, its impact on mood/quality of life (QOL) and the benefit of high calorie nutritional/other dietary supplements and percutaneous endoscopic gastrostomy (PEG).METHODS: 121 ALS patients were interviewed and answered standardized questionnaires (Beck depression inventory - II, SF36 Health Survey questionnaire, revised ALS functional rating scale). Two years after the initial survey we performed a follow-up interview.RESULTS: In our ALS-cohort, 56.3% of the patients suffered from weight loss. Weight loss had a negative impact on QOL and was associated with a shorter survival. Patients who took high calorie nutritional supplements respectively had a PEG stated a great benefit regarding weight stabilization and/or QOL.38.2% of our patients had significant weight loss without suffering from dysphagia. To clarify the reasons for weight loss in these patients, we compared them with patients without weight loss. The two groups did not differ regarding severity of disease, depression, frontotemporal dementia or fasciculations, but patients with weight loss declared more often increased respiratory work.CONCLUSIONS: Weight loss is a serious issue in ALS and cannot always be attributed to dysphagia. Symptomatic treatment of weight loss (high calorie nutritional supplements and/ or PEG) should be offered more frequently.

KW - Amyotrophic Lateral Sclerosis

KW - Cohort Studies

KW - Deglutition Disorders

KW - Endoscopy, Gastrointestinal

KW - Female

KW - Health Surveys

KW - Humans

KW - Male

KW - Middle Aged

KW - Nutrition Therapy

KW - Outpatients

KW - Quality of Life

KW - Regression Analysis

KW - Surveys and Questionnaires

KW - Weight Loss

KW - Journal Article

U2 - 10.1186/1471-2377-13-84

DO - 10.1186/1471-2377-13-84

M3 - SCORING: Journal article

C2 - 23848967

VL - 13

SP - 84

JO - BMC NEUROL

JF - BMC NEUROL

SN - 1471-2377

ER -