Vitamin E supplementation and lifespan in model organisms
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Vitamin E supplementation and lifespan in model organisms. / Wolf, Insa; Pallauf, K; Bendall, J K; Paulsen, L; Nikolai, S; Huebbe, P; Roeder, T; Rimbach, G.
In: AGEING RES REV, Vol. 12, No. 1, 01.01.2013, p. 365-75.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Vitamin E supplementation and lifespan in model organisms
AU - Wolf, Insa
AU - Pallauf, K
AU - Bendall, J K
AU - Paulsen, L
AU - Nikolai, S
AU - Huebbe, P
AU - Roeder, T
AU - Rimbach, G
N1 - Copyright © 2012 Elsevier B.V. All rights reserved.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - We have conducted a comprehensive literature review regarding the effect of vitamin E on lifespan in model organisms including single-cell organisms, rotifers, Caenorhabditis elegans, Drosophila melanogaster and laboratory rodents. We searched Pubmed and ISI Web of knowledge for studies up to 2011 using the terms "tocopherols", "tocotrienols", "lifespan" and "longevity" in the above mentioned model organisms. Twenty-four studies were included in the final analysis. While some studies suggest an increase in lifespan due to vitamin E, other studies did not observe any vitamin E-mediated changes in lifespan in model organisms. Furthermore there are several studies reporting a decrease in lifespan in response to vitamin E supplementation. Different outcomes between studies may be partly related to species-specific differences, differences in vitamin E concentrations and the vitamin E congeners administered. The findings of our literature review suggest that there is no consistent beneficial effect of vitamin E on lifespan in model organisms which is consistent with reports in human intervention studies.
AB - We have conducted a comprehensive literature review regarding the effect of vitamin E on lifespan in model organisms including single-cell organisms, rotifers, Caenorhabditis elegans, Drosophila melanogaster and laboratory rodents. We searched Pubmed and ISI Web of knowledge for studies up to 2011 using the terms "tocopherols", "tocotrienols", "lifespan" and "longevity" in the above mentioned model organisms. Twenty-four studies were included in the final analysis. While some studies suggest an increase in lifespan due to vitamin E, other studies did not observe any vitamin E-mediated changes in lifespan in model organisms. Furthermore there are several studies reporting a decrease in lifespan in response to vitamin E supplementation. Different outcomes between studies may be partly related to species-specific differences, differences in vitamin E concentrations and the vitamin E congeners administered. The findings of our literature review suggest that there is no consistent beneficial effect of vitamin E on lifespan in model organisms which is consistent with reports in human intervention studies.
KW - Animals
KW - Antioxidants
KW - Caenorhabditis elegans
KW - Diptera
KW - Drosophila
KW - Drosophila melanogaster
KW - Humans
KW - Longevity
KW - Mice
KW - Nematoda
KW - Rats
KW - Saccharomyces cerevisiae
KW - Vitamin E
U2 - 10.1016/j.arr.2012.10.002
DO - 10.1016/j.arr.2012.10.002
M3 - SCORING: Journal article
C2 - 23099151
VL - 12
SP - 365
EP - 375
JO - AGEING RES REV
JF - AGEING RES REV
SN - 1568-1637
IS - 1
ER -