Towards dynamical network biomarkers in neuromodulation of episodic migraine
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Towards dynamical network biomarkers in neuromodulation of episodic migraine. / Dahlem, Markus A; Rode, Sebastian; May, Arne; Fujiwara, Naoya; Hirata, Yoshito; Aihara, Kazuyuki; Kurths, Jürgen.
In: TRANSL NEUROSCI, Vol. 4, No. 3, 01.09.2013.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Towards dynamical network biomarkers in neuromodulation of episodic migraine
AU - Dahlem, Markus A
AU - Rode, Sebastian
AU - May, Arne
AU - Fujiwara, Naoya
AU - Hirata, Yoshito
AU - Aihara, Kazuyuki
AU - Kurths, Jürgen
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Computational methods have complemented experimental and clinical neurosciences and led to improvements in our understanding of the nervous systems in health and disease. In parallel, neuromodulation in form of electric and magnetic stimulation is gaining increasing acceptance in chronic and intractable diseases. In this paper, we firstly explore the relevant state of the art in fusion of both developments towards translational computational neuroscience. Then, we propose a strategy to employ the new theoretical concept of dynamical network biomarkers (DNB) in episodic manifestations of chronic disorders. In particular, as a first example, we introduce the use of computational models in migraine and illustrate on the basis of this example the potential of DNB as early-warning signals for neuromodulation in episodic migraine.
AB - Computational methods have complemented experimental and clinical neurosciences and led to improvements in our understanding of the nervous systems in health and disease. In parallel, neuromodulation in form of electric and magnetic stimulation is gaining increasing acceptance in chronic and intractable diseases. In this paper, we firstly explore the relevant state of the art in fusion of both developments towards translational computational neuroscience. Then, we propose a strategy to employ the new theoretical concept of dynamical network biomarkers (DNB) in episodic manifestations of chronic disorders. In particular, as a first example, we introduce the use of computational models in migraine and illustrate on the basis of this example the potential of DNB as early-warning signals for neuromodulation in episodic migraine.
U2 - 10.2478/s13380-013-0127-0
DO - 10.2478/s13380-013-0127-0
M3 - SCORING: Journal article
C2 - 24288590
VL - 4
JO - TRANSL NEUROSCI
JF - TRANSL NEUROSCI
SN - 2081-3856
IS - 3
ER -