The role of sleep and sleep deprivation in consolidating fear memories

M M Menz; JS Rihm; N Salari; J Born; R Kalisch; H C Pape; L Marshall; C Büchel

doi:10.1016/j.neuroimage.2013.03.001

The role of sleep and sleep deprivation in consolidating fear memories

Standard

The role of sleep and sleep deprivation in consolidating fear memories. / Menz, M M; Rihm, JS; Salari, N; Born, J; Kalisch, R; Pape, H C; Marshall, L; Büchel, C.

In: NEUROIMAGE, Vol. 75, 15.07.2013, p. 87-96.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Menz, MM, Rihm, JS, Salari, N, Born, J, Kalisch, R, Pape, HC, Marshall, L & Büchel, C 2013, 'The role of sleep and sleep deprivation in consolidating fear memories', NEUROIMAGE, vol. 75, pp. 87-96. https://doi.org/10.1016/j.neuroimage.2013.03.001

APA

Menz, M. M., Rihm, JS., Salari, N., Born, J., Kalisch, R., Pape, H. C., Marshall, L., & Büchel, C. (2013). The role of sleep and sleep deprivation in consolidating fear memories. NEUROIMAGE, 75, 87-96. https://doi.org/10.1016/j.neuroimage.2013.03.001

Vancouver

Menz MM, Rihm JS, Salari N, Born J, Kalisch R, Pape HC et al. The role of sleep and sleep deprivation in consolidating fear memories. NEUROIMAGE. 2013 Jul 15;75:87-96. https://doi.org/10.1016/j.neuroimage.2013.03.001

Bibtex

@article{11cef00ccf8c43d299cd7ef68fc72bf8,

title = "The role of sleep and sleep deprivation in consolidating fear memories",

abstract = "Sleep, in particular REM sleep, has been shown to improve the consolidation of emotional memories. Here, we investigated the role of sleep and sleep deprivation on the consolidation of fear memories and underlying neuronal mechanisms. We employed a Pavlovian fear conditioning paradigm either followed by a night of polysomnographically monitored sleep, or wakefulness in forty healthy participants. Recall of learned fear was better after sleep, as indicated by stronger explicitly perceived anxiety and autonomous nervous responses. These effects were positively correlated with the preceding time spent in REM sleep and paralleled by activation of the basolateral amygdala. These findings suggest REM sleep-associated consolidation of fear memory in the human amygdala. In view of the critical participation of fear learning mechanisms in the etiology of anxiety and post-traumatic stress disorder, deprivation of REM sleep after exposure to distressing events is an interesting target for further investigation.",

keywords = "Adult, Conditioning, Classical, Fear, Humans, Male, Memory, Polysomnography, Sleep, Sleep Deprivation, Sleep, REM, Young Adult",

author = "Menz, {M M} and JS Rihm and N Salari and J Born and R Kalisch and Pape, {H C} and L Marshall and C B{\"u}chel",

year = "2013",

month = jul,

day = "15",

doi = "10.1016/j.neuroimage.2013.03.001",

language = "English",

volume = "75",

pages = "87--96",

journal = "NEUROIMAGE",

issn = "1053-8119",

publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - The role of sleep and sleep deprivation in consolidating fear memories

AU - Menz, M M

AU - Rihm, JS

AU - Salari, N

AU - Born, J

AU - Kalisch, R

AU - Pape, H C

AU - Marshall, L

AU - Büchel, C

PY - 2013/7/15

Y1 - 2013/7/15

N2 - Sleep, in particular REM sleep, has been shown to improve the consolidation of emotional memories. Here, we investigated the role of sleep and sleep deprivation on the consolidation of fear memories and underlying neuronal mechanisms. We employed a Pavlovian fear conditioning paradigm either followed by a night of polysomnographically monitored sleep, or wakefulness in forty healthy participants. Recall of learned fear was better after sleep, as indicated by stronger explicitly perceived anxiety and autonomous nervous responses. These effects were positively correlated with the preceding time spent in REM sleep and paralleled by activation of the basolateral amygdala. These findings suggest REM sleep-associated consolidation of fear memory in the human amygdala. In view of the critical participation of fear learning mechanisms in the etiology of anxiety and post-traumatic stress disorder, deprivation of REM sleep after exposure to distressing events is an interesting target for further investigation.

AB - Sleep, in particular REM sleep, has been shown to improve the consolidation of emotional memories. Here, we investigated the role of sleep and sleep deprivation on the consolidation of fear memories and underlying neuronal mechanisms. We employed a Pavlovian fear conditioning paradigm either followed by a night of polysomnographically monitored sleep, or wakefulness in forty healthy participants. Recall of learned fear was better after sleep, as indicated by stronger explicitly perceived anxiety and autonomous nervous responses. These effects were positively correlated with the preceding time spent in REM sleep and paralleled by activation of the basolateral amygdala. These findings suggest REM sleep-associated consolidation of fear memory in the human amygdala. In view of the critical participation of fear learning mechanisms in the etiology of anxiety and post-traumatic stress disorder, deprivation of REM sleep after exposure to distressing events is an interesting target for further investigation.

KW - Adult

KW - Conditioning, Classical

KW - Fear

KW - Humans

KW - Male

KW - Memory

KW - Polysomnography

KW - Sleep

KW - Sleep Deprivation

KW - Sleep, REM

KW - Young Adult

U2 - 10.1016/j.neuroimage.2013.03.001

DO - 10.1016/j.neuroimage.2013.03.001

M3 - SCORING: Journal article

C2 - 23501052

VL - 75

SP - 87

EP - 96

JO - NEUROIMAGE

JF - NEUROIMAGE

SN - 1053-8119

ER -