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Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity

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Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity. / Ostkamp, Patrick; Salmen, Anke; Pignolet, Béatrice; Görlich, Dennis; Andlauer, Till F M; Schulte-Mecklenbeck, Andreas; Gonzalez-Escamilla, Gabriel; Bucciarelli, Florence; Gennero, Isabelle; Breuer, Johanna; Antony, Gisela; Schneider-Hohendorf, Tilman; Mykicki, Nadine; Bayas, Antonios; Then Bergh, Florian; Bittner, Stefan; Hartung, Hans-Peter; Friese, Manuel A; Linker, Ralf A; Luessi, Felix; Lehmann-Horn, Klaus; Mühlau, Mark; Paul, Friedemann; Stangel, Martin; Tackenberg, Björn; Tumani, Hayrettin; Warnke, Clemens; Weber, Frank; Wildemann, Brigitte; Zettl, Uwe K; Ziemann, Ulf; Müller-Myhsok, Bertram; Kümpfel, Tania; Klotz, Luisa; Meuth, Sven G; Zipp, Frauke; Hemmer, Bernhard; Hohlfeld, Reinhard; Brassat, David; Gold, Ralf; Gross, Catharina C; Lukas, Carsten; Groppa, Sergiu; Loser, Karin; Wiendl, Heinz; Schwab, Nicholas; German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network.

In: P NATL ACAD SCI USA, Vol. 118, No. 1, 05.01.2021, p. e2018457118.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ostkamp, P, Salmen, A, Pignolet, B, Görlich, D, Andlauer, TFM, Schulte-Mecklenbeck, A, Gonzalez-Escamilla, G, Bucciarelli, F, Gennero, I, Breuer, J, Antony, G, Schneider-Hohendorf, T, Mykicki, N, Bayas, A, Then Bergh, F, Bittner, S, Hartung, H-P, Friese, MA, Linker, RA, Luessi, F, Lehmann-Horn, K, Mühlau, M, Paul, F, Stangel, M, Tackenberg, B, Tumani, H, Warnke, C, Weber, F, Wildemann, B, Zettl, UK, Ziemann, U, Müller-Myhsok, B, Kümpfel, T, Klotz, L, Meuth, SG, Zipp, F, Hemmer, B, Hohlfeld, R, Brassat, D, Gold, R, Gross, CC, Lukas, C, Groppa, S, Loser, K, Wiendl, H, Schwab, N & German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network 2021, 'Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity', P NATL ACAD SCI USA, vol. 118, no. 1, pp. e2018457118. https://doi.org/10.1073/pnas.2018457118

APA

Ostkamp, P., Salmen, A., Pignolet, B., Görlich, D., Andlauer, T. F. M., Schulte-Mecklenbeck, A., Gonzalez-Escamilla, G., Bucciarelli, F., Gennero, I., Breuer, J., Antony, G., Schneider-Hohendorf, T., Mykicki, N., Bayas, A., Then Bergh, F., Bittner, S., Hartung, H-P., Friese, M. A., Linker, R. A., ... German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network (2021). Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity. P NATL ACAD SCI USA, 118(1), e2018457118. https://doi.org/10.1073/pnas.2018457118

Vancouver

Ostkamp P, Salmen A, Pignolet B, Görlich D, Andlauer TFM, Schulte-Mecklenbeck A et al. Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity. P NATL ACAD SCI USA. 2021 Jan 5;118(1):e2018457118. https://doi.org/10.1073/pnas.2018457118

Bibtex

@article{8b4ebd68345842bb96cc2326aa6d7c4c,
title = "Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity",
abstract = "Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (nNationMS = 946, nBIONAT = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-β-treated patients. In carriers of MC1R:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests beneficial effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.",
author = "Patrick Ostkamp and Anke Salmen and B{\'e}atrice Pignolet and Dennis G{\"o}rlich and Andlauer, {Till F M} and Andreas Schulte-Mecklenbeck and Gabriel Gonzalez-Escamilla and Florence Bucciarelli and Isabelle Gennero and Johanna Breuer and Gisela Antony and Tilman Schneider-Hohendorf and Nadine Mykicki and Antonios Bayas and {Then Bergh}, Florian and Stefan Bittner and Hans-Peter Hartung and Friese, {Manuel A} and Linker, {Ralf A} and Felix Luessi and Klaus Lehmann-Horn and Mark M{\"u}hlau and Friedemann Paul and Martin Stangel and Bj{\"o}rn Tackenberg and Hayrettin Tumani and Clemens Warnke and Frank Weber and Brigitte Wildemann and Zettl, {Uwe K} and Ulf Ziemann and Bertram M{\"u}ller-Myhsok and Tania K{\"u}mpfel and Luisa Klotz and Meuth, {Sven G} and Frauke Zipp and Bernhard Hemmer and Reinhard Hohlfeld and David Brassat and Ralf Gold and Gross, {Catharina C} and Carsten Lukas and Sergiu Groppa and Karin Loser and Heinz Wiendl and Nicholas Schwab and {German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network}",
note = "Copyright {\textcopyright} 2021 the Author(s). Published by PNAS.",
year = "2021",
month = jan,
day = "5",
doi = "10.1073/pnas.2018457118",
language = "English",
volume = "118",
pages = "e2018457118",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "1",

}

RIS

TY - JOUR

T1 - Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity

AU - Ostkamp, Patrick

AU - Salmen, Anke

AU - Pignolet, Béatrice

AU - Görlich, Dennis

AU - Andlauer, Till F M

AU - Schulte-Mecklenbeck, Andreas

AU - Gonzalez-Escamilla, Gabriel

AU - Bucciarelli, Florence

AU - Gennero, Isabelle

AU - Breuer, Johanna

AU - Antony, Gisela

AU - Schneider-Hohendorf, Tilman

AU - Mykicki, Nadine

AU - Bayas, Antonios

AU - Then Bergh, Florian

AU - Bittner, Stefan

AU - Hartung, Hans-Peter

AU - Friese, Manuel A

AU - Linker, Ralf A

AU - Luessi, Felix

AU - Lehmann-Horn, Klaus

AU - Mühlau, Mark

AU - Paul, Friedemann

AU - Stangel, Martin

AU - Tackenberg, Björn

AU - Tumani, Hayrettin

AU - Warnke, Clemens

AU - Weber, Frank

AU - Wildemann, Brigitte

AU - Zettl, Uwe K

AU - Ziemann, Ulf

AU - Müller-Myhsok, Bertram

AU - Kümpfel, Tania

AU - Klotz, Luisa

AU - Meuth, Sven G

AU - Zipp, Frauke

AU - Hemmer, Bernhard

AU - Hohlfeld, Reinhard

AU - Brassat, David

AU - Gold, Ralf

AU - Gross, Catharina C

AU - Lukas, Carsten

AU - Groppa, Sergiu

AU - Loser, Karin

AU - Wiendl, Heinz

AU - Schwab, Nicholas

AU - German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network

N1 - Copyright © 2021 the Author(s). Published by PNAS.

PY - 2021/1/5

Y1 - 2021/1/5

N2 - Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (nNationMS = 946, nBIONAT = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-β-treated patients. In carriers of MC1R:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests beneficial effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.

AB - Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (nNationMS = 946, nBIONAT = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-β-treated patients. In carriers of MC1R:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests beneficial effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.

U2 - 10.1073/pnas.2018457118

DO - 10.1073/pnas.2018457118

M3 - SCORING: Journal article

C2 - 33376202

VL - 118

SP - e2018457118

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 1

ER -