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Structural insights into transcription complexes

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Structural insights into transcription complexes. / Berger, Imre; Blanco, Alexandre G; Boelens, Rolf; Cavarelli, Jean; Coll, Miquel; Folkers, Gert E; Nie, Yan; Pogenberg, Vivian; Schultz, Patrick; Wilmanns, Matthias; Moras, Dino; Poterszman, Arnaud.

In: J STRUCT BIOL, Vol. 175, No. 2, 08.2011, p. 135-46.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Berger, I, Blanco, AG, Boelens, R, Cavarelli, J, Coll, M, Folkers, GE, Nie, Y, Pogenberg, V, Schultz, P, Wilmanns, M, Moras, D & Poterszman, A 2011, 'Structural insights into transcription complexes', J STRUCT BIOL, vol. 175, no. 2, pp. 135-46. https://doi.org/10.1016/j.jsb.2011.04.015

APA

Berger, I., Blanco, A. G., Boelens, R., Cavarelli, J., Coll, M., Folkers, G. E., Nie, Y., Pogenberg, V., Schultz, P., Wilmanns, M., Moras, D., & Poterszman, A. (2011). Structural insights into transcription complexes. J STRUCT BIOL, 175(2), 135-46. https://doi.org/10.1016/j.jsb.2011.04.015

Vancouver

Berger I, Blanco AG, Boelens R, Cavarelli J, Coll M, Folkers GE et al. Structural insights into transcription complexes. J STRUCT BIOL. 2011 Aug;175(2):135-46. https://doi.org/10.1016/j.jsb.2011.04.015

Bibtex

@article{7c99b9d07ec7425ba851a3dc2ed4584c,
title = "Structural insights into transcription complexes",
abstract = "Control of transcription allows the regulation of cell activity in response to external stimuli and research in the field has greatly benefited from efforts in structural biology. In this review, based on specific examples from the European SPINE2-COMPLEXES initiative, we illustrate the impact of structural proteomics on our understanding of the molecular basis of gene expression. While most atomic structures were obtained by X-ray crystallography, the impact of solution NMR and cryo-electron microscopy is far from being negligible. Here, we summarize some highlights and illustrate the importance of specific technologies on the structural biology of protein-protein or protein/DNA transcription complexes: structure/function analysis of components the eukaryotic basal and activated transcription machinery with focus on the TFIID and TFIIH multi-subunit complexes as well as transcription regulators such as members of the nuclear hormone receptor families. We also discuss molecular aspects of promoter recognition and epigenetic control of gene expression.",
keywords = "Allosteric Regulation, Animals, Cryoelectron Microscopy, Crystallography, X-Ray, Epigenesis, Genetic, Humans, Magnetic Resonance Spectroscopy, Multiprotein Complexes/chemistry, Promoter Regions, Genetic, Protein Conformation, Receptors, Cytoplasmic and Nuclear/chemistry, Transcription Factors/chemistry, Transcription, Genetic",
author = "Imre Berger and Blanco, {Alexandre G} and Rolf Boelens and Jean Cavarelli and Miquel Coll and Folkers, {Gert E} and Yan Nie and Vivian Pogenberg and Patrick Schultz and Matthias Wilmanns and Dino Moras and Arnaud Poterszman",
note = "Copyright {\textcopyright} 2011 Elsevier Inc. All rights reserved.",
year = "2011",
month = aug,
doi = "10.1016/j.jsb.2011.04.015",
language = "English",
volume = "175",
pages = "135--46",
journal = "J STRUCT BIOL",
issn = "1047-8477",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Structural insights into transcription complexes

AU - Berger, Imre

AU - Blanco, Alexandre G

AU - Boelens, Rolf

AU - Cavarelli, Jean

AU - Coll, Miquel

AU - Folkers, Gert E

AU - Nie, Yan

AU - Pogenberg, Vivian

AU - Schultz, Patrick

AU - Wilmanns, Matthias

AU - Moras, Dino

AU - Poterszman, Arnaud

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2011/8

Y1 - 2011/8

N2 - Control of transcription allows the regulation of cell activity in response to external stimuli and research in the field has greatly benefited from efforts in structural biology. In this review, based on specific examples from the European SPINE2-COMPLEXES initiative, we illustrate the impact of structural proteomics on our understanding of the molecular basis of gene expression. While most atomic structures were obtained by X-ray crystallography, the impact of solution NMR and cryo-electron microscopy is far from being negligible. Here, we summarize some highlights and illustrate the importance of specific technologies on the structural biology of protein-protein or protein/DNA transcription complexes: structure/function analysis of components the eukaryotic basal and activated transcription machinery with focus on the TFIID and TFIIH multi-subunit complexes as well as transcription regulators such as members of the nuclear hormone receptor families. We also discuss molecular aspects of promoter recognition and epigenetic control of gene expression.

AB - Control of transcription allows the regulation of cell activity in response to external stimuli and research in the field has greatly benefited from efforts in structural biology. In this review, based on specific examples from the European SPINE2-COMPLEXES initiative, we illustrate the impact of structural proteomics on our understanding of the molecular basis of gene expression. While most atomic structures were obtained by X-ray crystallography, the impact of solution NMR and cryo-electron microscopy is far from being negligible. Here, we summarize some highlights and illustrate the importance of specific technologies on the structural biology of protein-protein or protein/DNA transcription complexes: structure/function analysis of components the eukaryotic basal and activated transcription machinery with focus on the TFIID and TFIIH multi-subunit complexes as well as transcription regulators such as members of the nuclear hormone receptor families. We also discuss molecular aspects of promoter recognition and epigenetic control of gene expression.

KW - Allosteric Regulation

KW - Animals

KW - Cryoelectron Microscopy

KW - Crystallography, X-Ray

KW - Epigenesis, Genetic

KW - Humans

KW - Magnetic Resonance Spectroscopy

KW - Multiprotein Complexes/chemistry

KW - Promoter Regions, Genetic

KW - Protein Conformation

KW - Receptors, Cytoplasmic and Nuclear/chemistry

KW - Transcription Factors/chemistry

KW - Transcription, Genetic

U2 - 10.1016/j.jsb.2011.04.015

DO - 10.1016/j.jsb.2011.04.015

M3 - SCORING: Review article

C2 - 21571073

VL - 175

SP - 135

EP - 146

JO - J STRUCT BIOL

JF - J STRUCT BIOL

SN - 1047-8477

IS - 2

ER -