Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019.
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Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019. / Sutter, R; Hert, L; De, Marchis GM; Twerenbold, R; Kappos, L; Naegelin, Y; Kuster, GM; Benkert, P; Jost, J; Maceski, AM; Rüegg, S; Siegemund, M; Leppert, D; Kuhle, J.
In: ANN NEUROL, Vol. 89, No. 3, 03.2021, p. 610-616.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019.
AU - Sutter, R
AU - Hert, L
AU - De, Marchis GM
AU - Twerenbold, R
AU - Kappos, L
AU - Naegelin, Y
AU - Kuster, GM
AU - Benkert, P
AU - Jost, J
AU - Maceski, AM
AU - Rüegg, S
AU - Siegemund, M
AU - Leppert, D
AU - Kuhle, J
PY - 2021/3
Y1 - 2021/3
N2 - There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID-19), but little is known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal injury. We measured sNfL concentrations of 29 critically ill COVID-19 patients, 10 critically ill non-COVID-19 patients, and 259 healthy controls. After adjusting for neurological comorbidities and age, sNfL concentrations were higher in patients with COVID-19 versus both comparator groups. Higher sNfL levels were associated with unfavorable short-term outcome, indicating that neuronal injury is common and pronounced in critically ill patients. ANN NEUROL 2021;89:610-616.
AB - There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID-19), but little is known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal injury. We measured sNfL concentrations of 29 critically ill COVID-19 patients, 10 critically ill non-COVID-19 patients, and 259 healthy controls. After adjusting for neurological comorbidities and age, sNfL concentrations were higher in patients with COVID-19 versus both comparator groups. Higher sNfL levels were associated with unfavorable short-term outcome, indicating that neuronal injury is common and pronounced in critically ill patients. ANN NEUROL 2021;89:610-616.
UR - http://europepmc.org/abstract/med/33377539
U2 - 10.1002/ana.26004
DO - 10.1002/ana.26004
M3 - SCORING: Journal article
C2 - 33377539
VL - 89
SP - 610
EP - 616
JO - ANN NEUROL
JF - ANN NEUROL
SN - 0364-5134
IS - 3
ER -