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Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice

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Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice. / Brunne, Bianka; Franco, Santos; Bouché, Elisabeth; Herz, Joachim; Howell, Brian W; Pahle, Jasmine; Müller, Ulrich; May, Petra; Frotscher, Michael; Bock, Hans H.

In: GLIA, Vol. 61, No. 8, 01.08.2013, p. 1347-63.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Brunne, B, Franco, S, Bouché, E, Herz, J, Howell, BW, Pahle, J, Müller, U, May, P, Frotscher, M & Bock, HH 2013, 'Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice', GLIA, vol. 61, no. 8, pp. 1347-63. https://doi.org/10.1002/glia.22519

APA

Brunne, B., Franco, S., Bouché, E., Herz, J., Howell, B. W., Pahle, J., Müller, U., May, P., Frotscher, M., & Bock, H. H. (2013). Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice. GLIA, 61(8), 1347-63. https://doi.org/10.1002/glia.22519

Vancouver

Brunne B, Franco S, Bouché E, Herz J, Howell BW, Pahle J et al. Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice. GLIA. 2013 Aug 1;61(8):1347-63. https://doi.org/10.1002/glia.22519

Bibtex

@article{976cba0755d84149802c00b314413e8f,
title = "Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice",
abstract = "During dentate gyrus development, the early embryonic radial glial scaffold is replaced by a secondary glial scaffold around birth. In contrast to neocortical and early dentate gyrus radial glial cells, these postnatal glial cells are severely altered with regard to position and morphology in reeler mice lacking the secreted protein Reelin. In this study, we focus on the functional impact of these defects. Most radial glial cells throughout the nervous system serve as scaffolds for migrating neurons and precursor cells for both neurogenesis and gliogenesis. Precursor cell function has been demonstrated for secondary radial glial cells but the exact function of these late glial cells in granule cell migration and positioning is not clear. No data exist concerning the interplay between granule neurons and late radial glial cells during dentate gyrus development. Herein, we show that despite the severe morphological defects in the reeler dentate gyrus, the precursor function of secondary radial glial cells is not impaired during development in reeler mice. In addition, selective ablation of Disabled-1, an intracellular adaptor protein essential for Reelin signaling, in neurons but not in glial cells allowed us to distinguish effects of Reelin signaling on radial glial cells from possible secondary effects based on defective granule cells positioning.",
keywords = "Animals, Animals, Newborn, Cell Adhesion Molecules, Neuronal, Cells, Cultured, Dentate Gyrus, Ependymoglial Cells, Extracellular Matrix Proteins, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Knockout, Mice, Neurologic Mutants, Mutation, Nerve Tissue Proteins, Phenotype, Recombinant Proteins, Serine Endopeptidases, Signal Transduction, Stem Cells",
author = "Bianka Brunne and Santos Franco and Elisabeth Bouch{\'e} and Joachim Herz and Howell, {Brian W} and Jasmine Pahle and Ulrich M{\"u}ller and Petra May and Michael Frotscher and Bock, {Hans H}",
note = "Copyright {\textcopyright} 2013 Wiley Periodicals, Inc.",
year = "2013",
month = aug,
day = "1",
doi = "10.1002/glia.22519",
language = "English",
volume = "61",
pages = "1347--63",
journal = "GLIA",
issn = "0894-1491",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice

AU - Brunne, Bianka

AU - Franco, Santos

AU - Bouché, Elisabeth

AU - Herz, Joachim

AU - Howell, Brian W

AU - Pahle, Jasmine

AU - Müller, Ulrich

AU - May, Petra

AU - Frotscher, Michael

AU - Bock, Hans H

N1 - Copyright © 2013 Wiley Periodicals, Inc.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - During dentate gyrus development, the early embryonic radial glial scaffold is replaced by a secondary glial scaffold around birth. In contrast to neocortical and early dentate gyrus radial glial cells, these postnatal glial cells are severely altered with regard to position and morphology in reeler mice lacking the secreted protein Reelin. In this study, we focus on the functional impact of these defects. Most radial glial cells throughout the nervous system serve as scaffolds for migrating neurons and precursor cells for both neurogenesis and gliogenesis. Precursor cell function has been demonstrated for secondary radial glial cells but the exact function of these late glial cells in granule cell migration and positioning is not clear. No data exist concerning the interplay between granule neurons and late radial glial cells during dentate gyrus development. Herein, we show that despite the severe morphological defects in the reeler dentate gyrus, the precursor function of secondary radial glial cells is not impaired during development in reeler mice. In addition, selective ablation of Disabled-1, an intracellular adaptor protein essential for Reelin signaling, in neurons but not in glial cells allowed us to distinguish effects of Reelin signaling on radial glial cells from possible secondary effects based on defective granule cells positioning.

AB - During dentate gyrus development, the early embryonic radial glial scaffold is replaced by a secondary glial scaffold around birth. In contrast to neocortical and early dentate gyrus radial glial cells, these postnatal glial cells are severely altered with regard to position and morphology in reeler mice lacking the secreted protein Reelin. In this study, we focus on the functional impact of these defects. Most radial glial cells throughout the nervous system serve as scaffolds for migrating neurons and precursor cells for both neurogenesis and gliogenesis. Precursor cell function has been demonstrated for secondary radial glial cells but the exact function of these late glial cells in granule cell migration and positioning is not clear. No data exist concerning the interplay between granule neurons and late radial glial cells during dentate gyrus development. Herein, we show that despite the severe morphological defects in the reeler dentate gyrus, the precursor function of secondary radial glial cells is not impaired during development in reeler mice. In addition, selective ablation of Disabled-1, an intracellular adaptor protein essential for Reelin signaling, in neurons but not in glial cells allowed us to distinguish effects of Reelin signaling on radial glial cells from possible secondary effects based on defective granule cells positioning.

KW - Animals

KW - Animals, Newborn

KW - Cell Adhesion Molecules, Neuronal

KW - Cells, Cultured

KW - Dentate Gyrus

KW - Ependymoglial Cells

KW - Extracellular Matrix Proteins

KW - Mice

KW - Mice, 129 Strain

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Mice, Neurologic Mutants

KW - Mutation

KW - Nerve Tissue Proteins

KW - Phenotype

KW - Recombinant Proteins

KW - Serine Endopeptidases

KW - Signal Transduction

KW - Stem Cells

U2 - 10.1002/glia.22519

DO - 10.1002/glia.22519

M3 - SCORING: Journal article

C2 - 23828756

VL - 61

SP - 1347

EP - 1363

JO - GLIA

JF - GLIA

SN - 0894-1491

IS - 8

ER -