Reliability, validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with social phobia
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Reliability, validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with social phobia. / Sonntag, Michael; Konnopka, Alexander; Leichsenring, Falk; Salzer, Simone; Beutel, Manfred E; Herpertz, Stephan; Hiller, Wolfgang; Hoyer, Jürgen; Joraschky, Peter; Nolting, Björn; Pöhlmann, Karin; Stangier, Ulrich; Strauss, Bernhard; Willutzki, Ulrike; Wiltink, Jörg; Leibing, Eric; König, Hans-Helmut.
In: HEALTH QUAL LIFE OUT, Vol. 11, 01.01.2013, p. 215.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Reliability, validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with social phobia
AU - Sonntag, Michael
AU - Konnopka, Alexander
AU - Leichsenring, Falk
AU - Salzer, Simone
AU - Beutel, Manfred E
AU - Herpertz, Stephan
AU - Hiller, Wolfgang
AU - Hoyer, Jürgen
AU - Joraschky, Peter
AU - Nolting, Björn
AU - Pöhlmann, Karin
AU - Stangier, Ulrich
AU - Strauss, Bernhard
AU - Willutzki, Ulrike
AU - Wiltink, Jörg
AU - Leibing, Eric
AU - König, Hans-Helmut
PY - 2013/1/1
Y1 - 2013/1/1
N2 - OBJECTIVE: The aim of the study was to analyse the psychometric properties of the EQ-5D in patients with social phobia.METHODS: We used a sample of 445 patients with social phobia with five measurement points over a 30 month period. The discriminative ability of the EQ-5D was analysed by comparing the patients' responses with the general population and between different disease severity levels. For test-retest reliability we assessed the level of agreement in patients' responses over time, when there was no change in the Liebowitz Social Anxiety Scale (LSAS). Construct validity was analysed by identifying correlations of the EQ-5D with more specific instruments. For responsiveness we compared the means of EQ VAS/EQ-5D index anchored on improved (deteriorated) health status and computed effect sizes as well as a receiver operating characteristic (ROC) curve.RESULTS: Compared to the general population, patients with social phobia reported more problems in the dimensions "usual activities", "pain/discomfort", and "anxiety/depression" and less problems in "mobility" and "self-care". The EQ-5D was able to distinguish between different disease severity levels. The test-retest reliability was moderate (intraclass correlation coefficient > 0.6). Correlations between the EQ-5D and other instruments were mostly small except for correlations with Beck Depression Inventory. The EQ-5D index seemed to be more responsive than the EQ VAS, but with only medium effect sizes (0.5 < effect size < 0.8) in the British EQ-5D index and only significant in patients with improved health status. The ROC analysis revealed no significant results.CONCLUSIONS: The EQ-5D was moderately reliable and responsive in patients with improved health status. Construct validity was limited.TRIAL REGISTRATION: Current controlled trials ISRCTN53517394.
AB - OBJECTIVE: The aim of the study was to analyse the psychometric properties of the EQ-5D in patients with social phobia.METHODS: We used a sample of 445 patients with social phobia with five measurement points over a 30 month period. The discriminative ability of the EQ-5D was analysed by comparing the patients' responses with the general population and between different disease severity levels. For test-retest reliability we assessed the level of agreement in patients' responses over time, when there was no change in the Liebowitz Social Anxiety Scale (LSAS). Construct validity was analysed by identifying correlations of the EQ-5D with more specific instruments. For responsiveness we compared the means of EQ VAS/EQ-5D index anchored on improved (deteriorated) health status and computed effect sizes as well as a receiver operating characteristic (ROC) curve.RESULTS: Compared to the general population, patients with social phobia reported more problems in the dimensions "usual activities", "pain/discomfort", and "anxiety/depression" and less problems in "mobility" and "self-care". The EQ-5D was able to distinguish between different disease severity levels. The test-retest reliability was moderate (intraclass correlation coefficient > 0.6). Correlations between the EQ-5D and other instruments were mostly small except for correlations with Beck Depression Inventory. The EQ-5D index seemed to be more responsive than the EQ VAS, but with only medium effect sizes (0.5 < effect size < 0.8) in the British EQ-5D index and only significant in patients with improved health status. The ROC analysis revealed no significant results.CONCLUSIONS: The EQ-5D was moderately reliable and responsive in patients with improved health status. Construct validity was limited.TRIAL REGISTRATION: Current controlled trials ISRCTN53517394.
U2 - 10.1186/1477-7525-11-215
DO - 10.1186/1477-7525-11-215
M3 - SCORING: Journal article
C2 - 24365384
VL - 11
SP - 215
JO - HEALTH QUAL LIFE OUT
JF - HEALTH QUAL LIFE OUT
SN - 1477-7525
ER -
