Relation between platelet coagulant and vascular function, sex-specific analysis in adult survivors of childhood cancer compared to a population-based sample
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Relation between platelet coagulant and vascular function, sex-specific analysis in adult survivors of childhood cancer compared to a population-based sample. / Panova-Noeva, Marina; Wagner, Bianca; Nagler, Markus; Arnold, Natalie; Prochaska, Jürgen H; Eckerle, Susan; Spronk, Henri M; Merzenich, Hiltrud; Wingerter, Arthur; Schneider, Astrid; Danckwardt, Sven; Ten Cate, Hugo; Faber, Jörg; Wild, Philipp S.
In: SCI REP-UK, Vol. 9, No. 1, 27.12.2019, p. 20090.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
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TY - JOUR
T1 - Relation between platelet coagulant and vascular function, sex-specific analysis in adult survivors of childhood cancer compared to a population-based sample
AU - Panova-Noeva, Marina
AU - Wagner, Bianca
AU - Nagler, Markus
AU - Arnold, Natalie
AU - Prochaska, Jürgen H
AU - Eckerle, Susan
AU - Spronk, Henri M
AU - Merzenich, Hiltrud
AU - Wingerter, Arthur
AU - Schneider, Astrid
AU - Danckwardt, Sven
AU - Ten Cate, Hugo
AU - Faber, Jörg
AU - Wild, Philipp S
PY - 2019/12/27
Y1 - 2019/12/27
N2 - Female sex is a risk factor for long-term adverse outcome in cancer survivors, however very little is known for the underlying pathophysiological mechanisms rendering the increased risk. This study investigated sex-specifically the relation between thrombin generation (TG) with and without presence of platelets and vascular function in 200 adult survivors of a childhood cancer compared to 335 population-based control individuals. TG lag time, peak height and endogenous thrombin potential (ETP) measured in presence and absence of platelets were correlated to reflection index (RI) and stiffness index (SI). A sex-specific correlation analysis showed a negative relation in female survivors for platelet-dependent peak height and/or ETP and RI only. An age adjusted linear regression model confirmed the negative association between RI and platelet-dependent ETP (beta estimate: -6.85, 95% confidence interval: -12.19,-1.51) in females. Adjustment for cardiovascular risk factors resulted in loss of the association, whereby arterial hypertension and obesity showed the largest effects on the observed association. No other relevant associations were found in male and female cancer survivors and all population-based controls. This study demonstrates a link between platelet coagulant and vascular function of resistance vessels, found in female cancer survivors, potentially mediated by the presence of arterial hypertension and obesity.
AB - Female sex is a risk factor for long-term adverse outcome in cancer survivors, however very little is known for the underlying pathophysiological mechanisms rendering the increased risk. This study investigated sex-specifically the relation between thrombin generation (TG) with and without presence of platelets and vascular function in 200 adult survivors of a childhood cancer compared to 335 population-based control individuals. TG lag time, peak height and endogenous thrombin potential (ETP) measured in presence and absence of platelets were correlated to reflection index (RI) and stiffness index (SI). A sex-specific correlation analysis showed a negative relation in female survivors for platelet-dependent peak height and/or ETP and RI only. An age adjusted linear regression model confirmed the negative association between RI and platelet-dependent ETP (beta estimate: -6.85, 95% confidence interval: -12.19,-1.51) in females. Adjustment for cardiovascular risk factors resulted in loss of the association, whereby arterial hypertension and obesity showed the largest effects on the observed association. No other relevant associations were found in male and female cancer survivors and all population-based controls. This study demonstrates a link between platelet coagulant and vascular function of resistance vessels, found in female cancer survivors, potentially mediated by the presence of arterial hypertension and obesity.
KW - Adult
KW - Blood Coagulation Tests
KW - Blood Platelets/physiology
KW - Blood Vessels/physiopathology
KW - Cancer Survivors
KW - Child
KW - Female
KW - Humans
KW - Male
KW - Neoplasms/blood supply
U2 - 10.1038/s41598-019-56626-1
DO - 10.1038/s41598-019-56626-1
M3 - SCORING: Journal article
C2 - 31882836
VL - 9
SP - 20090
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
ER -