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Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depression

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Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depression. / Schecklmann, Martin; Dresler, Thomas; Beck, Stefanie; Jay, Johanna T; Febres, Richard; Haeusler, Julia; Jarczok, Tomasz A; Reif, Andreas; Plichta, Michael M; Ehlis, Ann-Christine; Fallgatter, Andreas J.

In: PSYCHIAT RES, Vol. 194, No. 3, 30.12.2011, p. 378-384.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schecklmann, M, Dresler, T, Beck, S, Jay, JT, Febres, R, Haeusler, J, Jarczok, TA, Reif, A, Plichta, MM, Ehlis, A-C & Fallgatter, AJ 2011, 'Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depression', PSYCHIAT RES, vol. 194, no. 3, pp. 378-384. https://doi.org/10.1016/j.pscychresns.2011.01.016

APA

Schecklmann, M., Dresler, T., Beck, S., Jay, J. T., Febres, R., Haeusler, J., Jarczok, T. A., Reif, A., Plichta, M. M., Ehlis, A-C., & Fallgatter, A. J. (2011). Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depression. PSYCHIAT RES, 194(3), 378-384. https://doi.org/10.1016/j.pscychresns.2011.01.016

Vancouver

Schecklmann M, Dresler T, Beck S, Jay JT, Febres R, Haeusler J et al. Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depression. PSYCHIAT RES. 2011 Dec 30;194(3):378-384. https://doi.org/10.1016/j.pscychresns.2011.01.016

Bibtex

@article{b0c1dce887e14856bbcae21beb69bf93,
title = "Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depression",
abstract = "Altered prefrontal brain activity (e.g. hypofrontality) during cognitive tasks such as working memory is a core neuroimaging marker in unipolar (UNI) and bipolar (BI) depression. The present study investigated for the first time UNI (n=16) and BI patients (n=14) in a working memory task including different processes (storage and matching) and components (object and spatial visual) with functional near-infrared spectroscopy (fNIRS) over the prefrontal cortex. In healthy controls (n=15) comparable to both patient groups, changes of oxygenated and deoxygenated haemoglobin indicated increased ventro-lateral, dorso-lateral prefrontal and superior frontal cortex activity for object and spatial visual working memory storage as compared to the control condition. In contrast, both patient groups showed diminished brain activity in all working memory conditions. Results revealed unspecific deficits that did not allow the differentiation between unipolar and bipolar depression in dependence of working memory processes or components. However, fNIRS can be considered as a valid, easy manageable, low cost and rapid tool for measuring (diminished) prefrontal cortex functions.",
keywords = "Adult, Brain Mapping, Depression/complications, Female, Hemoglobins/metabolism, Humans, Male, Memory Disorders/etiology, Memory, Short-Term/physiology, Middle Aged, Neuropsychological Tests, Prefrontal Cortex/metabolism, Reaction Time, Spectroscopy, Near-Infrared",
author = "Martin Schecklmann and Thomas Dresler and Stefanie Beck and Jay, {Johanna T} and Richard Febres and Julia Haeusler and Jarczok, {Tomasz A} and Andreas Reif and Plichta, {Michael M} and Ann-Christine Ehlis and Fallgatter, {Andreas J}",
note = "2011 Elsevier Ireland Ltd. All rights reserved.",
year = "2011",
month = dec,
day = "30",
doi = "10.1016/j.pscychresns.2011.01.016",
language = "English",
volume = "194",
pages = "378--384",
journal = "PSYCHIAT RES",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depression

AU - Schecklmann, Martin

AU - Dresler, Thomas

AU - Beck, Stefanie

AU - Jay, Johanna T

AU - Febres, Richard

AU - Haeusler, Julia

AU - Jarczok, Tomasz A

AU - Reif, Andreas

AU - Plichta, Michael M

AU - Ehlis, Ann-Christine

AU - Fallgatter, Andreas J

N1 - 2011 Elsevier Ireland Ltd. All rights reserved.

PY - 2011/12/30

Y1 - 2011/12/30

N2 - Altered prefrontal brain activity (e.g. hypofrontality) during cognitive tasks such as working memory is a core neuroimaging marker in unipolar (UNI) and bipolar (BI) depression. The present study investigated for the first time UNI (n=16) and BI patients (n=14) in a working memory task including different processes (storage and matching) and components (object and spatial visual) with functional near-infrared spectroscopy (fNIRS) over the prefrontal cortex. In healthy controls (n=15) comparable to both patient groups, changes of oxygenated and deoxygenated haemoglobin indicated increased ventro-lateral, dorso-lateral prefrontal and superior frontal cortex activity for object and spatial visual working memory storage as compared to the control condition. In contrast, both patient groups showed diminished brain activity in all working memory conditions. Results revealed unspecific deficits that did not allow the differentiation between unipolar and bipolar depression in dependence of working memory processes or components. However, fNIRS can be considered as a valid, easy manageable, low cost and rapid tool for measuring (diminished) prefrontal cortex functions.

AB - Altered prefrontal brain activity (e.g. hypofrontality) during cognitive tasks such as working memory is a core neuroimaging marker in unipolar (UNI) and bipolar (BI) depression. The present study investigated for the first time UNI (n=16) and BI patients (n=14) in a working memory task including different processes (storage and matching) and components (object and spatial visual) with functional near-infrared spectroscopy (fNIRS) over the prefrontal cortex. In healthy controls (n=15) comparable to both patient groups, changes of oxygenated and deoxygenated haemoglobin indicated increased ventro-lateral, dorso-lateral prefrontal and superior frontal cortex activity for object and spatial visual working memory storage as compared to the control condition. In contrast, both patient groups showed diminished brain activity in all working memory conditions. Results revealed unspecific deficits that did not allow the differentiation between unipolar and bipolar depression in dependence of working memory processes or components. However, fNIRS can be considered as a valid, easy manageable, low cost and rapid tool for measuring (diminished) prefrontal cortex functions.

KW - Adult

KW - Brain Mapping

KW - Depression/complications

KW - Female

KW - Hemoglobins/metabolism

KW - Humans

KW - Male

KW - Memory Disorders/etiology

KW - Memory, Short-Term/physiology

KW - Middle Aged

KW - Neuropsychological Tests

KW - Prefrontal Cortex/metabolism

KW - Reaction Time

KW - Spectroscopy, Near-Infrared

U2 - 10.1016/j.pscychresns.2011.01.016

DO - 10.1016/j.pscychresns.2011.01.016

M3 - SCORING: Journal article

C2 - 22079657

VL - 194

SP - 378

EP - 384

JO - PSYCHIAT RES

JF - PSYCHIAT RES

SN - 0165-1781

IS - 3

ER -