Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma.
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Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma. / Löbel, Ulrike; Sedlacik, Jan; Reddick, W E; Kocak, M; Ji, Q; Broniscer, A; Hillenbrand, C M; Patay, Z.
In: AM J NEURORADIOL, Vol. 32, No. 2, 2, 2011, p. 315-322.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma.
AU - Löbel, Ulrike
AU - Sedlacik, Jan
AU - Reddick, W E
AU - Kocak, M
AU - Ji, Q
AU - Broniscer, A
AU - Hillenbrand, C M
AU - Patay, Z
PY - 2011
Y1 - 2011
N2 - Focal anaplasia characterized by T2 hypointensity, signal-intensity enhancement on postcontrast T1-weighted MR imaging and restricted water diffusion has been reported in a patient with juvenile pilocytic astrocytoma. We identified T2(HOF) with these MR imaging characteristics in children with DIPG and hypothesized that these represent areas of focal anaplasia; and may, therefore, have increased perfusion properties and should be characterized by increased perfusion. Thus, we used DSC to investigate our hypothesis.
AB - Focal anaplasia characterized by T2 hypointensity, signal-intensity enhancement on postcontrast T1-weighted MR imaging and restricted water diffusion has been reported in a patient with juvenile pilocytic astrocytoma. We identified T2(HOF) with these MR imaging characteristics in children with DIPG and hypothesized that these represent areas of focal anaplasia; and may, therefore, have increased perfusion properties and should be characterized by increased perfusion. Thus, we used DSC to investigate our hypothesis.
M3 - SCORING: Journal article
VL - 32
SP - 315
EP - 322
JO - AM J NEURORADIOL
JF - AM J NEURORADIOL
SN - 0195-6108
IS - 2
M1 - 2
ER -