Probe-based confocal laser endomicroscopy in double balloon enteroscopy

Stephan Miehlke; A Morgner; D Aust; G Baretton; A Madisch

doi:10.1055/s-0031-1282025

Probe-based confocal laser endomicroscopy in double balloon enteroscopy

Standard

Probe-based confocal laser endomicroscopy in double balloon enteroscopy. / Miehlke, Stephan; Morgner, A; Aust, D; Baretton, G; Madisch, A.

In: Z GASTROENTEROL, Vol. 49, No. 12, 07.2011, p. 1529-34.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Miehlke, S, Morgner, A, Aust, D, Baretton, G & Madisch, A 2011, 'Probe-based confocal laser endomicroscopy in double balloon enteroscopy', Z GASTROENTEROL, vol. 49, no. 12, pp. 1529-34. https://doi.org/10.1055/s-0031-1282025

APA

Miehlke, S., Morgner, A., Aust, D., Baretton, G., & Madisch, A. (2011). Probe-based confocal laser endomicroscopy in double balloon enteroscopy. Z GASTROENTEROL, 49(12), 1529-34. https://doi.org/10.1055/s-0031-1282025

Vancouver

Miehlke S, Morgner A, Aust D, Baretton G, Madisch A. Probe-based confocal laser endomicroscopy in double balloon enteroscopy. Z GASTROENTEROL. 2011 Jul;49(12):1529-34. https://doi.org/10.1055/s-0031-1282025

Bibtex

@article{3183f57c2cd14e13b3fd8aae69434de9,

title = "Probe-based confocal laser endomicroscopy in double balloon enteroscopy",

abstract = "BACKGROUND: Probe-based confocal laser endomicroscopy (pCLE) allows in-vivo assessment of the gastrointestinal mucosal architecture during ongoing endoscopy. We investigated the feasibility and safety of pCLE during double balloon enteroscopy (DBE).METHODS: DBE was performed using the Fujinon EN-450P5. pCLE (Cellvizio-GI{\textregistered}, Mauna Kea Technologies) was performed after intravenous injection of 5-10 mL fluorescein 1 % using a 1.8-mm probe (GastroFlex/ColoFlex Z-probe) at the deepest point of DBE insertion and in case of any pathological lesion. Primary outcome measure was technical success, defined as (i) successful advancement of the probe at the deepest DBE insertion and (ii) successful pCLE imaging of the intestinal mucosa. Secondary outcome was safety of the pCLE procedure.RESULTS: 27 DBE procedures (14 antegrade) were performed in 16 patients. The mean depth of small bowel insertion was 255 cm for antegrade and 130 cm for retrograde DBE. Technical success of pCLE was achieved in 96.3 % (antegrade 92.8 %, retrograde 100 %). One technical failure occurred (incomplete probe advancement). There were no adverse events related to the pCLE procedure. pCLE imaging of the small bowel mucosal architecture was possible in all cases. Pathological conditions within the small bowel such as loss of villi, crypt hyperplasia, advanced neoplasia, or increased blood flow due to inflammation tissue could be successful visualized.CONCLUSION: This study is the first to demonstrate successful and safe application of pCLE in the deep small bowel during double balloon enteroscopy. Further studies are needed to determine the clinical benefit of pCLE in the management of patients with small bowel diseases.",

keywords = "Adult, Aged, Double-Balloon Enteroscopy, Female, Humans, Intestinal Diseases, Intestine, Small, Male, Microscopy, Confocal, Middle Aged, Surgery, Computer-Assisted, Transducers, Treatment Outcome, Journal Article",

author = "Stephan Miehlke and A Morgner and D Aust and G Baretton and A Madisch",

note = "{\textcopyright} Georg Thieme Verlag KG Stuttgart · New York.",

year = "2011",

month = jul,

doi = "10.1055/s-0031-1282025",

language = "English",

volume = "49",

pages = "1529--34",

journal = "Z GASTROENTEROL",

issn = "0044-2771",

publisher = "Karl Demeter Verlag GmbH",

number = "12",

}

RIS

TY - JOUR

T1 - Probe-based confocal laser endomicroscopy in double balloon enteroscopy

AU - Miehlke, Stephan

AU - Morgner, A

AU - Aust, D

AU - Baretton, G

AU - Madisch, A

N1 - © Georg Thieme Verlag KG Stuttgart · New York.

PY - 2011/7

Y1 - 2011/7

N2 - BACKGROUND: Probe-based confocal laser endomicroscopy (pCLE) allows in-vivo assessment of the gastrointestinal mucosal architecture during ongoing endoscopy. We investigated the feasibility and safety of pCLE during double balloon enteroscopy (DBE).METHODS: DBE was performed using the Fujinon EN-450P5. pCLE (Cellvizio-GI®, Mauna Kea Technologies) was performed after intravenous injection of 5-10 mL fluorescein 1 % using a 1.8-mm probe (GastroFlex/ColoFlex Z-probe) at the deepest point of DBE insertion and in case of any pathological lesion. Primary outcome measure was technical success, defined as (i) successful advancement of the probe at the deepest DBE insertion and (ii) successful pCLE imaging of the intestinal mucosa. Secondary outcome was safety of the pCLE procedure.RESULTS: 27 DBE procedures (14 antegrade) were performed in 16 patients. The mean depth of small bowel insertion was 255 cm for antegrade and 130 cm for retrograde DBE. Technical success of pCLE was achieved in 96.3 % (antegrade 92.8 %, retrograde 100 %). One technical failure occurred (incomplete probe advancement). There were no adverse events related to the pCLE procedure. pCLE imaging of the small bowel mucosal architecture was possible in all cases. Pathological conditions within the small bowel such as loss of villi, crypt hyperplasia, advanced neoplasia, or increased blood flow due to inflammation tissue could be successful visualized.CONCLUSION: This study is the first to demonstrate successful and safe application of pCLE in the deep small bowel during double balloon enteroscopy. Further studies are needed to determine the clinical benefit of pCLE in the management of patients with small bowel diseases.

AB - BACKGROUND: Probe-based confocal laser endomicroscopy (pCLE) allows in-vivo assessment of the gastrointestinal mucosal architecture during ongoing endoscopy. We investigated the feasibility and safety of pCLE during double balloon enteroscopy (DBE).METHODS: DBE was performed using the Fujinon EN-450P5. pCLE (Cellvizio-GI®, Mauna Kea Technologies) was performed after intravenous injection of 5-10 mL fluorescein 1 % using a 1.8-mm probe (GastroFlex/ColoFlex Z-probe) at the deepest point of DBE insertion and in case of any pathological lesion. Primary outcome measure was technical success, defined as (i) successful advancement of the probe at the deepest DBE insertion and (ii) successful pCLE imaging of the intestinal mucosa. Secondary outcome was safety of the pCLE procedure.RESULTS: 27 DBE procedures (14 antegrade) were performed in 16 patients. The mean depth of small bowel insertion was 255 cm for antegrade and 130 cm for retrograde DBE. Technical success of pCLE was achieved in 96.3 % (antegrade 92.8 %, retrograde 100 %). One technical failure occurred (incomplete probe advancement). There were no adverse events related to the pCLE procedure. pCLE imaging of the small bowel mucosal architecture was possible in all cases. Pathological conditions within the small bowel such as loss of villi, crypt hyperplasia, advanced neoplasia, or increased blood flow due to inflammation tissue could be successful visualized.CONCLUSION: This study is the first to demonstrate successful and safe application of pCLE in the deep small bowel during double balloon enteroscopy. Further studies are needed to determine the clinical benefit of pCLE in the management of patients with small bowel diseases.

KW - Adult

KW - Aged

KW - Double-Balloon Enteroscopy

KW - Female

KW - Humans

KW - Intestinal Diseases

KW - Intestine, Small

KW - Male

KW - Microscopy, Confocal

KW - Middle Aged

KW - Surgery, Computer-Assisted

KW - Transducers

KW - Treatment Outcome

KW - Journal Article

U2 - 10.1055/s-0031-1282025

DO - 10.1055/s-0031-1282025

M3 - SCORING: Journal article

C2 - 22139876

VL - 49

SP - 1529

EP - 1534

JO - Z GASTROENTEROL

JF - Z GASTROENTEROL

SN - 0044-2771

IS - 12

ER -