Occupational asbestos exposure as a risk factor for laryngeal carcinoma in a population-based case-control study from Germany
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Occupational asbestos exposure as a risk factor for laryngeal carcinoma in a population-based case-control study from Germany. / Ramroth, Heribert; Ahrens, Wolfgang; Dietz, Andreas; Becher, Heiko.
In: AM J IND MED, Vol. 54, No. 7, 01.07.2011, p. 510-4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Occupational asbestos exposure as a risk factor for laryngeal carcinoma in a population-based case-control study from Germany
AU - Ramroth, Heribert
AU - Ahrens, Wolfgang
AU - Dietz, Andreas
AU - Becher, Heiko
N1 - Copyright © 2011 Wiley-Liss, Inc.
PY - 2011/7/1
Y1 - 2011/7/1
N2 - BACKGROUND: As several studies have identified asbestos exposure as an independent occupational risk factor for laryngeal cancer, the aim of our study was to confirm this association.METHODS: In a population-based case-control study on laryngeal cancer in South-West Germany occupational exposures and other risk factors were obtained by face-to-face interviews using a detailed standardized questionnaire covering the complete individual working history, supplemented by job-specific questionnaires (JSQ) especially for selected jobs known to entail exposure to asbestos. Detailed exposure information was collected over a wide range of asbestos related jobs and branches and analyzed using different modeling strategies.RESULTS: Seventy-three (28.4%) cases and 158 (20.5%) controls reported any exposure to asbestos. Elevated risk estimates for asbestos exposure were found. However, those became substantially reduced after adjustment for smoking and alcohol.CONCLUSION: Moderately elevated risks for laryngeal cancer after exposure to asbestos were confirmed. Difficulties in the collection of adequate exposure data were demonstrated.
AB - BACKGROUND: As several studies have identified asbestos exposure as an independent occupational risk factor for laryngeal cancer, the aim of our study was to confirm this association.METHODS: In a population-based case-control study on laryngeal cancer in South-West Germany occupational exposures and other risk factors were obtained by face-to-face interviews using a detailed standardized questionnaire covering the complete individual working history, supplemented by job-specific questionnaires (JSQ) especially for selected jobs known to entail exposure to asbestos. Detailed exposure information was collected over a wide range of asbestos related jobs and branches and analyzed using different modeling strategies.RESULTS: Seventy-three (28.4%) cases and 158 (20.5%) controls reported any exposure to asbestos. Elevated risk estimates for asbestos exposure were found. However, those became substantially reduced after adjustment for smoking and alcohol.CONCLUSION: Moderately elevated risks for laryngeal cancer after exposure to asbestos were confirmed. Difficulties in the collection of adequate exposure data were demonstrated.
KW - Aged
KW - Asbestos
KW - Case-Control Studies
KW - Confidence Intervals
KW - Female
KW - Germany
KW - Humans
KW - Laryngeal Neoplasms
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Occupational Diseases
KW - Occupational Exposure
KW - Odds Ratio
KW - Questionnaires
KW - Risk Factors
U2 - 10.1002/ajim.20963
DO - 10.1002/ajim.20963
M3 - SCORING: Journal article
C2 - 21538446
VL - 54
SP - 510
EP - 514
JO - AM J IND MED
JF - AM J IND MED
SN - 0271-3586
IS - 7
ER -