Neutrophil-derived cathelicidin protects from neointimal hyperplasia
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Neutrophil-derived cathelicidin protects from neointimal hyperplasia. / Soehnlein, Oliver; Wantha, Sarawuth; Simsekyilmaz, Sakine; Döring, Yvonne; Megens, Remco T A; Mause, Sebastian F; Drechsler, Maik; Smeets, Ralf; Weinandy, Stefan; Schreiber, Fabian; Gries, Thomas; Jockenhoevel, Stefan; Möller, Martin; Vijayan, Santosh; van Zandvoort, Marc A M J; Agerberth, Birgitta; Pham, Christine T; Gallo, Richard L; Hackeng, Tilman M; Liehn, Elisa A; Zernecke, Alma; Klee, Doris; Weber, Christian.
In: SCI TRANSL MED, Vol. 3, No. 103, 05.10.2011, p. 103ra98.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Neutrophil-derived cathelicidin protects from neointimal hyperplasia
AU - Soehnlein, Oliver
AU - Wantha, Sarawuth
AU - Simsekyilmaz, Sakine
AU - Döring, Yvonne
AU - Megens, Remco T A
AU - Mause, Sebastian F
AU - Drechsler, Maik
AU - Smeets, Ralf
AU - Weinandy, Stefan
AU - Schreiber, Fabian
AU - Gries, Thomas
AU - Jockenhoevel, Stefan
AU - Möller, Martin
AU - Vijayan, Santosh
AU - van Zandvoort, Marc A M J
AU - Agerberth, Birgitta
AU - Pham, Christine T
AU - Gallo, Richard L
AU - Hackeng, Tilman M
AU - Liehn, Elisa A
AU - Zernecke, Alma
AU - Klee, Doris
AU - Weber, Christian
PY - 2011/10/5
Y1 - 2011/10/5
N2 - Percutaneous transluminal angioplasty with stent implantation is used to dilate arteries narrowed by atherosclerotic plaques and to revascularize coronary arteries occluded by atherothrombosis in myocardial infarction. Commonly applied drug-eluting stents release antiproliferative or anti-inflammatory agents to reduce the incidence of in-stent stenosis. However, these stents may still lead to in-stent stenosis; they also show increased rates of late stent thrombosis, an obstacle to optimal revascularization possibly related to endothelial recovery. Here, we examined the contribution of neutrophils and neutrophilic granule proteins to arterial healing after injury. We found that neutrophil-borne cathelicidin (mouse CRAMP, human LL-37) promoted reendothelization and thereby limited neointima formation after stent implantation. We then translated these findings to an animal model using a neutrophil-instructing, biofunctionalized, miniaturized Nitinol stent coated with LL-37. This stent reduced in-stent stenosis in a mouse model of atherosclerosis, suggesting that LL-37 may promote vascular healing after interventional therapy.
AB - Percutaneous transluminal angioplasty with stent implantation is used to dilate arteries narrowed by atherosclerotic plaques and to revascularize coronary arteries occluded by atherothrombosis in myocardial infarction. Commonly applied drug-eluting stents release antiproliferative or anti-inflammatory agents to reduce the incidence of in-stent stenosis. However, these stents may still lead to in-stent stenosis; they also show increased rates of late stent thrombosis, an obstacle to optimal revascularization possibly related to endothelial recovery. Here, we examined the contribution of neutrophils and neutrophilic granule proteins to arterial healing after injury. We found that neutrophil-borne cathelicidin (mouse CRAMP, human LL-37) promoted reendothelization and thereby limited neointima formation after stent implantation. We then translated these findings to an animal model using a neutrophil-instructing, biofunctionalized, miniaturized Nitinol stent coated with LL-37. This stent reduced in-stent stenosis in a mouse model of atherosclerosis, suggesting that LL-37 may promote vascular healing after interventional therapy.
KW - Animals
KW - Antimicrobial Cationic Peptides
KW - Apolipoproteins E
KW - Atherosclerosis
KW - Cells, Cultured
KW - Drug-Eluting Stents
KW - Hyperplasia
KW - Mice
KW - Mice, Knockout
KW - Neointima
KW - Neutrophils
U2 - 10.1126/scitranslmed.3002531
DO - 10.1126/scitranslmed.3002531
M3 - SCORING: Journal article
C2 - 21974936
VL - 3
SP - 103ra98
JO - SCI TRANSL MED
JF - SCI TRANSL MED
SN - 1946-6234
IS - 103
ER -