Neuroimaging in anxiety disorders.
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Neuroimaging in anxiety disorders. / Holzschneider, Kathrin; Mulert, Christoph.
In: DIALOGUES CLIN NEURO, Vol. 13, No. 4, 4, 2011, p. 453-461.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Neuroimaging in anxiety disorders.
AU - Holzschneider, Kathrin
AU - Mulert, Christoph
PY - 2011
Y1 - 2011
N2 - Over the last few years, neuroimaging techniques have contributed greatly to the identification of the structural and functional neuroanatomy of anxiety disorders. The amygdala seems to be a crucial structure for fear and anxiety, and has consistently been found to be activated in anxiety-provoking situations. Apart from the amygdala, the insula and anterior cinguiate cortex seem to be critical, and ail three have been referred to as the "fear network." In the present article, we review the main findings from three major lines of research. First, we examine human models of anxiety disorders, including fear conditioning studies and investigations of experimentally induced panic attacks. Then we turn to research in patients with anxiety disorders and take a dose look at post-traumatic stress disorder and obsessive-compulsive disorder. Finally, we review neuroimaging studies investigating neural correlates of successful treatment of anxiety, focusing on exposure-based therapy and several pharmacological treatment options, as well as combinations of both.
AB - Over the last few years, neuroimaging techniques have contributed greatly to the identification of the structural and functional neuroanatomy of anxiety disorders. The amygdala seems to be a crucial structure for fear and anxiety, and has consistently been found to be activated in anxiety-provoking situations. Apart from the amygdala, the insula and anterior cinguiate cortex seem to be critical, and ail three have been referred to as the "fear network." In the present article, we review the main findings from three major lines of research. First, we examine human models of anxiety disorders, including fear conditioning studies and investigations of experimentally induced panic attacks. Then we turn to research in patients with anxiety disorders and take a dose look at post-traumatic stress disorder and obsessive-compulsive disorder. Finally, we review neuroimaging studies investigating neural correlates of successful treatment of anxiety, focusing on exposure-based therapy and several pharmacological treatment options, as well as combinations of both.
KW - Humans
KW - Positron-Emission Tomography
KW - Magnetic Resonance Imaging
KW - Amygdala/physiopathology/radionuclide imaging
KW - Anxiety Disorders/physiopathology/radionuclide imaging
KW - Tomography, Emission-Computed, Single-Photon
KW - Humans
KW - Positron-Emission Tomography
KW - Magnetic Resonance Imaging
KW - Amygdala/physiopathology/radionuclide imaging
KW - Anxiety Disorders/physiopathology/radionuclide imaging
KW - Tomography, Emission-Computed, Single-Photon
M3 - SCORING: Journal article
VL - 13
SP - 453
EP - 461
JO - DIALOGUES CLIN NEURO
JF - DIALOGUES CLIN NEURO
SN - 1294-8322
IS - 4
M1 - 4
ER -
