Neural correlates of the emotional Stroop task in panic disorder patients: an event-related fMRI study.
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Neural correlates of the emotional Stroop task in panic disorder patients: an event-related fMRI study. / Dresler, Thomas; Hindi Attar, Catherine; Spitzer, Carsten; Löwe, Bernd; Deckert, Jürgen; Büchel, Christian; Ehlis, Ann-Christine; Fallgatter, Andreas J.
In: J PSYCHIATR RES, Vol. 46, No. 12, 12, 2012, p. 1627-1634.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Neural correlates of the emotional Stroop task in panic disorder patients: an event-related fMRI study.
AU - Dresler, Thomas
AU - Hindi Attar, Catherine
AU - Spitzer, Carsten
AU - Löwe, Bernd
AU - Deckert, Jürgen
AU - Büchel, Christian
AU - Ehlis, Ann-Christine
AU - Fallgatter, Andreas J
PY - 2012
Y1 - 2012
N2 - Although being a standard tool to assess interference effects of disorder-specific words in clinical samples, the neural underpinnings of the emotional Stroop task are still not well understood and have hardly been investigated in experimental case-control studies. We therefore used functional magnetic resonance imaging (fMRI) to examine the attentional bias toward panic-related words in panic disorder (PD) patients and healthy controls. Twenty PD patients (with or without agoraphobia) and 23 healthy controls matched for age and gender performed an event-related emotional Stroop task with panic-related and neutral words while undergoing 3 Tesla fMRI. On the behavioral level, PD patients showed a significant emotional Stroop effect, i.e. color-naming of panic-related words was prolonged compared to neutral words. This effect was not observed in the control group. PD patients further differed from controls on the neural level in showing increased BOLD activity in the left inferior frontal gyrus in response to panic-related relative to neutral words. PD patients showed the expected attentional bias, i.e. an altered processing of disorder-specific stimuli. This emotional Stroop effect was paralleled by increased activation in the left prefrontal cortex which may indicate altered processing of emotional stimulus material.
AB - Although being a standard tool to assess interference effects of disorder-specific words in clinical samples, the neural underpinnings of the emotional Stroop task are still not well understood and have hardly been investigated in experimental case-control studies. We therefore used functional magnetic resonance imaging (fMRI) to examine the attentional bias toward panic-related words in panic disorder (PD) patients and healthy controls. Twenty PD patients (with or without agoraphobia) and 23 healthy controls matched for age and gender performed an event-related emotional Stroop task with panic-related and neutral words while undergoing 3 Tesla fMRI. On the behavioral level, PD patients showed a significant emotional Stroop effect, i.e. color-naming of panic-related words was prolonged compared to neutral words. This effect was not observed in the control group. PD patients further differed from controls on the neural level in showing increased BOLD activity in the left inferior frontal gyrus in response to panic-related relative to neutral words. PD patients showed the expected attentional bias, i.e. an altered processing of disorder-specific stimuli. This emotional Stroop effect was paralleled by increased activation in the left prefrontal cortex which may indicate altered processing of emotional stimulus material.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Emotions/physiology
KW - Agoraphobia/physiopathology
KW - Brain/physiopathology
KW - Magnetic Resonance Imaging/instrumentation/methods
KW - Panic Disorder/physiopathology
KW - Prefrontal Cortex/physiopathology
KW - Psycholinguistics/instrumentation
KW - Stroop Test
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Emotions/physiology
KW - Agoraphobia/physiopathology
KW - Brain/physiopathology
KW - Magnetic Resonance Imaging/instrumentation/methods
KW - Panic Disorder/physiopathology
KW - Prefrontal Cortex/physiopathology
KW - Psycholinguistics/instrumentation
KW - Stroop Test
M3 - SCORING: Journal article
VL - 46
SP - 1627
EP - 1634
JO - J PSYCHIATR RES
JF - J PSYCHIATR RES
SN - 0022-3956
IS - 12
M1 - 12
ER -