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Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning

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Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning. / Haaker, Jan; Maren, Stephen; Andreatta, Marta; Merz, Christian J; Richter, Jan; Richter, S Helene; Meir Drexler, Shira; Lange, Maren D; Jüngling, Kay; Nees, Frauke; Seidenbecher, Thomas; Fullana, Miquel A; Wotjak, Carsten T; Lonsdorf, Tina B.

In: NEUROSCI BIOBEHAV R, Vol. 107, 12.2019, p. 329-345.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Haaker, J, Maren, S, Andreatta, M, Merz, CJ, Richter, J, Richter, SH, Meir Drexler, S, Lange, MD, Jüngling, K, Nees, F, Seidenbecher, T, Fullana, MA, Wotjak, CT & Lonsdorf, TB 2019, 'Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning', NEUROSCI BIOBEHAV R, vol. 107, pp. 329-345. https://doi.org/10.1016/j.neubiorev.2019.09.020

APA

Haaker, J., Maren, S., Andreatta, M., Merz, C. J., Richter, J., Richter, S. H., Meir Drexler, S., Lange, M. D., Jüngling, K., Nees, F., Seidenbecher, T., Fullana, M. A., Wotjak, C. T., & Lonsdorf, T. B. (2019). Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning. NEUROSCI BIOBEHAV R, 107, 329-345. https://doi.org/10.1016/j.neubiorev.2019.09.020

Vancouver

Haaker J, Maren S, Andreatta M, Merz CJ, Richter J, Richter SH et al. Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning. NEUROSCI BIOBEHAV R. 2019 Dec;107:329-345. https://doi.org/10.1016/j.neubiorev.2019.09.020

Bibtex

@article{fe5a4401878a433eba1318c39357b7f5,
title = "Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning",
abstract = "Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.",
author = "Jan Haaker and Stephen Maren and Marta Andreatta and Merz, {Christian J} and Jan Richter and Richter, {S Helene} and {Meir Drexler}, Shira and Lange, {Maren D} and Kay J{\"u}ngling and Frauke Nees and Thomas Seidenbecher and Fullana, {Miquel A} and Wotjak, {Carsten T} and Lonsdorf, {Tina B}",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2019",
month = dec,
doi = "10.1016/j.neubiorev.2019.09.020",
language = "English",
volume = "107",
pages = "329--345",
journal = "NEUROSCI BIOBEHAV R",
issn = "0149-7634",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning

AU - Haaker, Jan

AU - Maren, Stephen

AU - Andreatta, Marta

AU - Merz, Christian J

AU - Richter, Jan

AU - Richter, S Helene

AU - Meir Drexler, Shira

AU - Lange, Maren D

AU - Jüngling, Kay

AU - Nees, Frauke

AU - Seidenbecher, Thomas

AU - Fullana, Miquel A

AU - Wotjak, Carsten T

AU - Lonsdorf, Tina B

N1 - Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2019/12

Y1 - 2019/12

N2 - Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.

AB - Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.

U2 - 10.1016/j.neubiorev.2019.09.020

DO - 10.1016/j.neubiorev.2019.09.020

M3 - SCORING: Review article

C2 - 31521698

VL - 107

SP - 329

EP - 345

JO - NEUROSCI BIOBEHAV R

JF - NEUROSCI BIOBEHAV R

SN - 0149-7634

ER -